Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

Journal of Cell Biology

Volumn 156, Issue 6, 2002, Pages 1015-1028

  Bonangelino, Cecilia J ^a   Nau, Johnathan J ^b   Duex, Jason E ^a   Brinkman, Mikala ^a   Wurmser, Andrew E ^b   Gary, Jonathan D ^a   Emr, Scott D ^a   Weisman, Lois S ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

FAB1; Phosphatidylinositol; Ptdlns(3,5)P2; VAC14; Vacuole

Indexed keywords

ENZYME ACTIVATOR; PHOSPHATIDYLINOSITOL 3,5 BIDPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOTRANSFERASE; POLYPHOSPHOINOSITIDE; PROTEIN FAB1P; PROTEIN VAC14P; PROTEIN VAC7P; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL STRUCTURE; CHROMOSOME DELETION; GENE IDENTIFICATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STEADY STATE; VEGETATIVE GROWTH;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BASE SEQUENCE; CHROMOSOME DELETION; GENE EXPRESSION REGULATION, FUNGAL; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; OSMOTIC PRESSURE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; UP-REGULATION; VACUOLES; YEASTS;

EID: 0037128929     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201002     Document Type: Article

References (62)

1. Basic local alignment search tool
2. Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides
3. Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2
4. Inositol trisphosphate and calcium signalling
5. Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology
6. Endocytosis: How dynamin sets vesicles PHre!
7. Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells
8. Traffic into the prevacuolar/endosomal compartment of Saccharomyces cerevisiae: A VPS45-dependent intracellular route and a VPS45-independent, endocytic route
9. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
10. Aquaporins in Saccharomyces: Characterization of a second functional water channel protein
11. The PLC1 encoded phospholipase C in the yeast Saccharomyces cerevisiae is essential for glucose-induced phosphatidylinositol turnover and activation of plasma membrane H+-ATP-ase
12. In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae
13. The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
14. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole
15. Wortmannin causes mistargeting of procathepsin D. Evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes
16. Rapid DNA isolation for enzymatic and hybridization analysis
17. Phosphoinositides as regulators in membrane traffic
18. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
19. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
20. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis
21. Interaction of the EEA1 FYVE Finger with phosphatidylinositol 3-phosphate and early endosomes
22. Chracterization of new vacuolar segregation mutants, isolated by screening for loss of proteinase B self-activation
23. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors
24. Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate
25. 2+-activated secretion
26. An essential role for a protein and lipid kinase complex in secretory protein sorting
27. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ
28. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
29. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking
30. Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation
31. Phosphatidylinositol transfer proteins: The long and winding road to physiological function
32. Actin cytoskeleton: Thinking globally, actin locally
33. Signal transduction and membrane traffic: The PITP/phosphoinositide connection
34. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase
35. Transport processes of solutes across the vacuolar membrane of higher plants
36. Aquaporins. A molecular entry into plant water relations
37. Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
38. Existence of a tightly regulated water channel in Saccharomyces cerevisiae
39. The multiplying roles of inositol lipids and phosphates in cell control processes
40. Phosphoinositide signaling and the regulation of membrane trafficking in yeast
41. A functional PtdIns(3)P-binding motif
42. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
43. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
44. Lipid regulators of membrane traffic through the Golgi complex
45. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
46. Getting started with yeast
47. A system of shuttle vectors and yeast host strains designed for efficient manipulations of DNA in Saccharomyces cerevisiae
48. Vesicle-mediated protein transport: Regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
49. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
50. FYVE-finger proteins - Effectors of an inositol lipid
51. Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates
52. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting
53. Signalling through the lipid products of phosphoinositide-3-OH kinase
54. Purification fo yeast vacuolar membrane H+-ATPase and enzymological discrimination of three ATP-driven proton pumps in Saccharomyces cerevisiae
55. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
56. Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly
57. Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole
58. Fusion of docked membranes requires the armadillo repeat protein Vac8p
59. Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycle
60. D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor
61. Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts
62. Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast