Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: A region critical for biological activity

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24508-24518

  Chen, Quan ^a   Pinon, Delia I ^a   Miller, Laurence J ^a   Dong, Maoqing ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; LABELING; LIGANDS; PEPTIDES; TISSUE;

AMINO-TERMINAL DOMAIN; AMINO-TERMINAL REGION; BIOLOGICAL ACTIVITIES; CARBOXYL-TERMINAL; COUPLED RECEPTORS; COVALENT ATTACHMENT; EXTRACELLULAR LOOPS; MOLECULAR BASIS; NATURAL LIGANDS; SMALL MOLECULES; TRANSMEMBRANE SEGMENTS; TYPE 2 DIABETES MELLITUS;

PROBES;

G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; TYROSINE; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; HORMONE; LIGAND; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGICAL ACTIVITY; CHO CELL; CONTROLLED STUDY; COVALENT BOND; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RADIOCHEMISTRY; RECEPTOR BINDING; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; HUMAN; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GLUCAGON-LIKE PEPTIDE 1; HORMONES; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955302857     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.135749     Document Type: Article

References (61)

1. Baggio, L. L., and Drucker, D. J. (2007) Gastroenterology 132, 2131-2157
2. Drucker, D. J. (2005) Nat. Clin. Pract. Endocrinol. Metab. 1, 22-31
3. Estall, J. L., and Drucker, D. J. (2006) Curr. Pharm. Des. 12, 1731-1750
4. Mayo, K. E., Miller, L. J., Bataille, D., Dalle, S., Göke, B., Thorens, B., and Drucker, D. J. (2003) Pharmacol. Rev. 55, 167-194
5. Bazarsuren, A., Grauschopf, U., Wozny, M., Reusch, D., Hoffmann, E., Schaefer, W., Panzner, S., and Rudolph, R. (2002) Biophys. Chem. 96, 305-318
6. Dong, M., Lam, P. C., Gao, F., Hosohata, K., Pinon, D. I., Sexton, P. M., Abagyan, R., and Miller, L. J. (2007) Mol. Pharmacol. 72, 280-290
7. Grace, C. R., Perrin, M. H., DiGruccio, M. R., Miller, C. L., Rivier, J. E., Vale, W. W., and Riek, R. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 12836-12841
8. Grauschopf, U., Lilie, H., Honold, K., Wozny, M., Reusch, D., Esswein, A., Schäfer, W., Rücknagel, K. P., and Rudolph, R. (2000) Biochemistry 39, 8878-8887
9. Sun, C., Song, D., Davis-Taber, R. A., Barrett, L. W., Scott, V. E., Richardson, P. L., Pereda-Lopez, A., Uchic, M. E., Solomon, L. R., Lake, M. R., Walter, K. A., Hajduk, P. J., and Olejniczak, E. T. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 7875-7880
10. Cao, Y. J., Gimpl, G., and Fahrenholz, F. (1995) Biochem. Biophys. Res. Commun. 212, 673-680
11. Gourlet, P., Vilardaga, J. P., De Neef, P., Waelbroeck, M., Vandermeers, A., and Robberecht, P. (1996) Peptides 17, 825-829
12. Graziano, M. P., Hey, P. J., and Strader, C. D. (1996) Receptors Channels 4, 9-17
13. Holtmann, M. H., Hadac, E. M., and Miller, L. J. (1995) J. Biol. Chem. 270, 14394-14398
14. Jüppner, H., Schipani, E., Bringhurst, F. R., McClure, I., Keutmann, H. T., Potts, J. T., Jr., Kronenberg, H. M., Abou-Samra, A. B., Segre, G. V., and Gardella, T. J. (1994) Endocrinology 134, 879-884
15. Stroop, S. D., Nakamuta, H., Kuestner, R. E., Moore, E. E., and Epand, R. M. (1996) Endocrinology 137, 4752-4756
16. Runge, S., Wulff, B. S., Madsen, K., Bräuner-Osborne, H., and Knudsen, L. B. (2003) Br. J. Pharmacol. 138, 787-794
17. Hoare, S. R. (2005) Drug Discov. Today 10, 417-427
18. Bisello, A., Adams, A. E., Mierke, D. F., Pellegrini, M., Rosenblatt, M., Suva, L. J., and Chorev, M. (1998) J. Biol. Chem. 273, 22498-22505
19. Dong, M., Li, Z., Pinon, D. I., Lybrand, T. P., and Miller, L. J. (2004) J. Biol. Chem. 279, 2894-2903
20. Dong, M., Pinon, D. I., Cox, R. F., and Miller, L. J. (2004) J. Biol. Chem. 279, 31177-31182
21. Grace, C. R., Perrin, M. H., Gulyas, J., Digruccio, M. R., Cantle, J. P., Rivier, J. E., Vale, W. W., and Riek, R. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 4858-4863
22. Pioszak, A. A., Parker, N. R., Suino-Powell, K., and Xu, H. E. (2008) J. Biol. Chem. 283, 32900-32912
23. Pioszak, A. A., and Xu, H. E. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 5034-5039
24. Runge, S., Thøgersen, H., Madsen, K., Lau, J., and Rudolph, R. (2008) J. Biol. Chem. 283, 11340-11347
25. Underwood, C. R., Garibay, P., Knudsen, L. B., Hastrup, S., Peters, G. H., Rudolph, R., and Reedtz-Runge, S. (2010) J. Biol. Chem. 285, 723-730
26. Parthier, C., Reedtz-Runge, S., Rudolph, R., and Stubbs, M. T. (2009) Trends Biochem. Sci. 34, 303-310
27. Chen, Q., Pinon, D. I., Miller, L. J., and Dong, M. (2009) J. Biol. Chem. 284, 34135-34144
28. Adelhorst, K., Hedegaard, B. B., Knudsen, L. B., and Kirk, O. (1994) J. Biol. Chem. 269, 6275-6278
29. Powers, S. P., Pinon, D. I., and Miller, L. J. (1988) Int. J. Pept. Protein Res. 31, 429-434
30. Ulrich, C. D., 2nd, Pinon, D. I., Hadac, E. M., Holicky, E. L., Chang-Miller, A., Gates, L. K., and Miller, L. J. (1993) Gastroenterology 105, 1534-1543
31. Dong, M., Gao, F., Pinon, D. I., and Miller, L. J. (2008) Mol. Endocrinol. 22, 1489-1499
32. Holtmann, M. H., Ganguli, S., Hadac, E. M., Dolu, V., and Miller, L. J. (1996) J. Biol. Chem. 271, 14944-14949
33. Hadac, E. M., Ghanekar, D. V., Holicky, E. L., Pinon, D. I., Dougherty, R. W., and Miller, L. J. (1996) Pancreas 13, 130-139
34. Munson, P. J., and Rodbard, D. (1980) Anal. Biochem. 107, 220-239
35. Dong, M., Wang, Y., Pinon, D. I., Hadac, E. M., and Miller, L. J. (1999) J. Biol. Chem. 274, 903-909
36. Ji, Z., Hadac, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., and Miller, L. J. (1997) J. Biol. Chem. 272, 24393-24401
37. Murakami, M., and Kouyama, T. (2008) Nature 453, 363-367
38. López de Maturana, R., Treece-Birch, J., Abidi, F., Findlay, J. B., and Donnelly, D. (2004) Protein Pept. Lett. 11, 15-22
39. Kraetke, O., Holeran, B., Berger, H., Escher, E., Bienert, M., and Beyermann, M. (2005) Biochemistry 44, 15569-15577
40. Gallwitz, B., Witt, M., Paetzold, G., Morys-Wortmann, C., Zimmermann, B., Eckart, K., Fölsch, U. R., and Schmidt, W. E. (1994) Eur. J. Biochem. 225, 1151-1156
41. Tokuyama, Y., Matsui, K., Egashira, T., Nozaki, O., Ishizuka, T., and Kanatsuka, A. (2004) Diabetes Res. Clin. Pract. 66, 63-69
42. Beinborn, M., Worrall, C. I., McBride, E. W., and Kopin, A. S. (2005) Regul. Pept. 130, 1-6
43. Dong, M., Pinon, D. I., Cox, R. F., and Miller, L. J. (2004) J. Biol. Chem. 279, 1167-1175
44. Gensure, R. C., Gardella, T. J., and Jüppner, H. (2001) J. Biol. Chem. 276, 28650-28658
45. Zhou, A. T., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L. J., and Chorev, M. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 3644-3649
46. Wittelsberger, A., Corich, M., Thomas, B. E., Lee, B. K., Barazza, A., Czodrowski, P., Mierke, D. F., Chorev, M., and Rosenblatt, M. (2006) Biochemistry 45, 2027-2034
47. Ceraudo, E., Murail, S., Tan, Y. V., Lacapère, J. J., Neumann, J. M., Couvineau, A., and Laburthe, M. (2008) Mol. Endocrinol. 22, 147-155
48. Ceraudo, E., Tan, Y. V., Nicole, P., Couvineau, A., and Laburthe, M. (2008) J. Mol. Neurosci. 36, 245-248
49. Tan, Y. V., Couvineau, A., Murail, S., Ceraudo, E., Neumann, J. M., Lacapère, J. J., and Laburthe, M. (2006) J. Biol. Chem. 281, 12792-12798
50. Dong, M., Cox, R. F., and Miller, L. J. (2009) J. Biol. Chem. 284, 21839-21847
51. López de Maturana, R., and Donnelly, D. (2002) FEBS Lett. 530, 244-248
52. Xiao, Q., Jeng, W., and Wheeler, M. B. (2000) J. Mol. Endocrinol. 25, 321-335
53. Piserchio, A., Bisello, A., Rosenblatt, M., Chorev, M., and Mierke, D. F. (2000) Biochemistry 39, 8153-8160
54. Du, K., Nicole, P., Couvineau, A., and Laburthe, M. (1997) Biochem. Biophys. Res. Commun. 230, 289-292
55. Gensure, R. C., Shimizu, N., Tsang, J., and Gardella, T. J. (2003) Mol. Endocrinol. 17, 2647-2658
56. Greenberg, Z., Bisello, A., Mierke, D. F., Rosenblatt, M., and Chorev, M. (2000) Biochemistry 39, 8142-8152
57. Dong, M., Lam, P. C., Pinon, D. I., Sexton, P. M., Abagyan, R., and Miller, L. J. (2008) Mol. Pharmacol. 74, 413-422
58. Behar, V., Bisello, A., Bitan, G., Rosenblatt, M., and Chorev, M. (2000) J. Biol. Chem. 275, 9-17
59. Behar, V., Bisello, A., Rosenblatt, M., and Chorev, M. (1999) Endocrinology 140, 4251-4261
60. Monaghan, P., Thomas, B. E., Woznica, I., Wittelsberger, A., Mierke, D. F., and Rosenblatt, M. (2008) Biochemistry 47, 5889-5895
61. Lin, F., and Wang, R. (2009) J. Mol. Model. 15, 53-65