Nanoscaled buffering zone of charged (PLGA) n-b-bPEI micelles in acidic microclimate for potential protein delivery application

Journal of Controlled Release

Volumn 160, Issue 3, 2012, Pages 440-450

  Kang, Han Chang ^a,b   Lee, Ji Eun ^a,c   Bae, You Han ^a,d  

^a UNIVERSITY OF UTAH   (United States)

^b The Catholic University of Korea   (South Korea)

^c Inha University School of Medicine   (South Korea)

^d Utah Inha DDS and Advanced Theapeutics Research Center   (South Korea)

Author keywords

Charged micelle; Microclimate pH; Microsphere; Nanoenvironmental pH; Poly(lactide co glycolide); Protein delivery

Indexed keywords

ACIDIC MICROENVIRONMENT; ANIONIC MICELLES; BUFFERING CAPACITIES; CATIONIC MICELLES; CHARGED MICELLES; CONTROLLED RELEASE; DEGRADATION PRODUCTS; NANO-SIZED PARTICLES; NANOSCALED; PH CHANGE; PLGA MICROSPHERES; POLY LACTIDE-CO-GLYCOLIDE; POLYETHYLENEIMINE; POLYMERIC ARCHITECTURE; POTENTIAL PROTEINS; PRIMARY AMINES; PROTEIN DELIVERY; PROTEIN FORMULATION; PROTEIN LOADINGS; PROTEIN-POLYMER INTERACTION; RELEASE PROFILES; REVERSE MICELLES; WEIGHT RATIOS;

CARBOXYLATION; DEGRADATION; INSULIN; LOADING; MICROSPHERES; POLYMER BLENDS; POLYMERS; PROTEINS; PROTONS;

MICELLES;

BUFFER; MICROSPHERE; NANOPARTICLE; POLYETHYLENEIMINE DERIVATIVE; POLYGLACTIN; PROTON;

ACIDITY; AQUEOUS SOLUTION; ARTICLE; CARBOXYLATION; CHEMICAL MODIFICATION; COMPLEX FORMATION; MICELLE; MICROCLIMATE; NANOANALYSIS; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE MICELLE;

DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; INSULIN; LACTIC ACID; MICELLES; MICROSPHERES; MURAMIDASE; NANOTECHNOLOGY; POLYETHYLENEIMINE; POLYGLYCOLIC ACID;

EID: 84861997997     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.02.024     Document Type: Article

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