Comparison of the effects of Mg(OH)2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly(D,L-lactide-co-glycolide) implants

Biomaterials

Volumn 23, Issue 1, 2002, Pages 239-245

  Kang, Jichao ^a   Schwendeman, Steven P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bovine serum albumin; Magnesium hydroxide; Microclimate pH; Poly(D,L lactide co glycolide); Sucrose; Tissue plasminogen activator

Indexed keywords

MAGNESIUM COMPOUNDS; PH EFFECTS; PROTEINS; REACTION KINETICS; SORPTION;

WATER SORPTION;

SUGAR (SUCROSE);

ALTEPLASE; BOVINE SERUM ALBUMIN; MAGNESIUM HYDROXIDE; POLYGLACTIN; SUCROSE; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG IMPLANT; DRUG STABILITY; ENCAPSULATION; IMPLANT; PH; PRIORITY JOURNAL; PROTEIN STABILITY; SCANNING ELECTRON MICROSCOPY;

DRUG IMPLANTS; LACTIC ACID; MAGNESIUM HYDROXIDE; MICROSCOPY, ELECTRON, SCANNING; POLYGLYCOLIC ACID; POLYMERS; SERUM ALBUMIN, BOVINE; SUCROSE; WATER;

BOVINAE;

EID: 0036027563     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(01)00101-6     Document Type: Article

References (28)

1. Controlled release of bioactive agents from lactide/glycolide polymer
2. Stability of atriopeptin III in poly(D,L-lacide-co-glycolide) microspheres
3. Strategies for stabilizing tetanus toxoid towards the development of a single-dose tetanus vaccine
4. Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres
5. Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins
6. A biodegradable delivery system for peptides; preclinical experience with the gonadotrophin-releasing hormone agonist Zoladex
7. A month-long effect from a single injection of microencapsulated human growth hormone
8. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide)
9. Stability of protein pharmaceuticals
10. Formulation and delivery of proteins and peptides design and development strategies
11. Stability of proteins and their delivery from biodegradable polymer microspheres
12. Peptides, proteins, and vaccine delivery from implantable polymeric systems
13. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres; release kinetics and stability issues
14. Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants; mechanism of stabilization by basic additives
15. The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins
16. Controlled release of polypeptides from polyanhydrides
17. Solution formulation of proteins/peptides
18. Freeze-drying concepts; the basics
19. The effect of a water/organic solvent interface on the structural stability of lysozyme
20. Development of a multiple-drug delivery implant for intraocular management of proliferative vitreoretinopathy
21. The role of moisture in protein stability
22. Water sorption and solid-state stability of proteins
23. Effect of fabrication technique on the erosion characteristics of polyanhydride matrices
24. The control of protein stability and association by weak interactions with water; how do solvents affect these processes?
25. Stability characterization and formulation development of Alteplase, a recombined tissue plasminogen activator
26. Pharmacokinetics and pharmacodynamics of tenecteplase; results from a phase II study in patients with acute myocardial infarction
27. New thrombolytic strategy; bolus administration of t-PA and urokinase-fibrinogen conjugate
28. Hydrogel systems for barriers and local drug delivery in the control of wound healing