Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells

Biomaterials

Volumn 31, Issue 11, 2010, Pages 3071-3078

  Kang, Han Chang ^a   Samsonova, Olga ^a,b   Bae, You Han ^a,c  

^a UNIVERSITY OF UTAH   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c Advanced Therapeutics Research Center   (South Korea)

Author keywords

Multidrug resistance; pH trafficking; Poly(l lysine); Polyethyleneimine; Polymeric gene delivery; Solid tumors

Indexed keywords

GENE DELIVERY; L-LYSINE; MULTIDRUG RESISTANCE; POLYETHYLENEIMINE; SOLID TUMORS;

AMINO ACIDS; CHEMOTHERAPY; CYTOLOGY; ELECTROMAGNETIC WAVE EMISSION; FUNCTIONAL POLYMERS; GENE TRANSFER; NUCLEIC ACIDS; ONCOLOGY; TUMORS;

CELLS;

DOXORUBICIN; POLYCATION; POLYETHYLENEIMINE; POLYLYSINE;

ACIDIFICATION; ARTICLE; BREAST CANCER; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG SENSITIVITY; ENDOCYTOSIS; ENDOSOME; GENE DELIVERY SYSTEM; GENE VECTOR; HUMAN; HUMAN CELL; LYSOSOME; MICROENVIRONMENT; MULTIDRUG RESISTANCE; PH; PRIORITY JOURNAL; TUMOR ESCAPE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENETIC VECTORS; HUMANS; HYDROGEN-ION CONCENTRATION; POLYAMINES;

EID: 76749103359     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.001     Document Type: Article

References (38)

1. Larsen A.K., Escargueil A.E., and Skladanowski A. Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacol Ther 85 (2000) 217-229
2. Stavrovskaya A.A. Cellular mechanisms of multidrug resistance of tumor cells. Biochemistry (Mosc) 65 (2000) 95-106
3. Simon S., Roy D., and Schindler M. Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci U S A 91 (1994) 1128-1132
4. Modok S., Mellor H.R., and Callaghan R. Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer. Curr Opin Pharmacol 6 (2006) 350-354
5. Simon S.M. Role of organelle pH in tumor cell biology and drug resistance. Drug Discov Today 4 (1999) 32-38
6. Mohajer G., Lee E.S., and Bae Y.H. Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells. Pharm Res 24 (2007) 1618-1627
7. +-ATPase in vesicular trafficking: targeting, regulation and function. Curr Opin Cell Biol 20 (2008) 415-426
8. +)-ATPases-nature's most versatile proton pumps. Nat Rev Mol Cell Biol 3 (2002) 94-103
9. You H., Jin J., Shu H., Yu B., De Milito A., Lozupone F., et al. Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells. Cancer Lett 280 (2009) 110-119
10. +-ATPase subunit C is overexpressed in multidrug-resistant HL60 cells. Biochem Biophys Res Comm 182 (1992) 675-681
11. Maxfield F.R., and McGraw T.E. Endocytic recycling. Nat Rev Mol Cell Biol 5 (2004) 121-132
12. Sehested M., Skovsgaard T., van Deurs B., and Winther-Nielsen H. Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil. Br J Cancer 56 (1987) 747-751
13. Sehested M., Skovsgaard T., van Deurs B., and Winther-Nielsen H. Increase in nonspecific adsorptive endocytosis in anthracycline- and vinca alkaloid-resistant Ehrlich ascites tumor cell lines. J Natl Cancer Inst 78 (1987) 171-179
14. Cosson P., de Curtis I., Pouyssegur J., Griffiths G., and Davoust J. Low cytoplasmic pH inhibits endocytosis and transport from the trans-Golgi network to the cell surface. J Cell Biol 108 (1989) 377-387
15. Park J.S., Han T.H., Lee K.Y., Han S.S., Hwang J.J., Moon D.H., et al. N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release. J Control Release 115 (2006) 37-45
16. Lee E.S., Gao Z., and Bae Y.H. Recent progress in tumor pH targeting nanotechnology. J Control Release 132 (2008) 164-170
17. Kim D., Lee E.S., Oh K.T., Gao Z.G., and Bae Y.H. Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Small 4 (2008) 2043-2050
18. Kaneda Y., and Tabata Y. Non-viral vectors for cancer therapy. Cancer Sci 97 (2006) 348-354
19. Morille M., Passirani C., Vonarbourg A., Clavreul A., and Benoit J.P. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 29 (2008) 3477-3496
20. Kang H.C., Lee M., and Bae Y.H. Polymeric gene carriers. Crit Rev Eukaryot Gene Expr 15 (2005) 317-342
21. Kang H.C., and Bae Y.H. pH-Tunable endosomolytic oligomers for enhanced nucleic acid delivery. Adv Funct Mater 17 (2007) 1263-1272
22. Kang H.C., Lee E.S., Na K., and Bae Y.H. Stimuli-sensitive nanosystems: for drug and gene delivery. In: Torchilin V.P. (Ed). Multifunctional Pharmaceutical nanocarriers (2008), Springer, New York 161-199
23. Purpus E.J., and McCue P.A. High efficiency DNA transfection in murine embryonal carcinoma cells: expression of pSV3neo in wild type and retinoid-resistant cell lines. Int J Dev Biol 37 (1993) 117-124
24. Kang H.C., and Bae Y.H. Polymeric gene transfection on insulin-secreting cells: sulfonylurea receptor-mediation and transfection medium effect. Pharm Res 23 (2006) 1797-1808
25. Kang H.C., Kim S., Lee M., and Bae Y.H. Polymeric gene carrier for insulin secreting cells: poly(l-lysine)-g-sulfonylurea for receptor mediated transfection. J Control Release 105 (2005) 164-176
26. Kang H.C., and Bae Y.H. Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector. Biomaterials 30 (2009) 2837-2845
27. Florea B.I., Meaney C., Junginger H.E., and Borchard G. Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures. AAPS PharmSci 4 (2002) E12
28. Kang H.C., and Bae Y.H. Transfection of rat pancreatic islet tissue by polymeric gene vectors. Diabetes Technol Ther 11 (2009) 443-449
29. Morimoto K., Nishikawa M., Kawakami S., Nakano T., Hattori Y., Fumoto S., et al. Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver. Mol Ther 7 (2003) 254-261
30. Lechardeur D., Verkman A.S., and Lukacs G.L. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv Drug Deliv Rev 57 (2005) 755-767
31. Sonawane N.D., Szoka Jr. F.C., and Verkman A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 278 (2003) 44826-44831
32. Forrest M.L., and Pack D.W. On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design. Mol Ther 6 (2002) 57-66
33. Akinc A., and Langer R. Measuring the pH environment of DNA delivered using nonviral vectors: implications for lysosomal trafficking. Biotechnol Bioeng 78 (2002) 503-508
34. Belhoussine R., Morjani H., Sharonov S., Ploton D., and Manfait M. Characterization of intracellular pH gradients in human multidrug-resistant tumor cells by means of scanning microspectrofluorometry and dual-emission-ratio probes. Int J Cancer 81 (1999) 81-89
35. Altan N., Chen Y., Schindler M., and Simon S.M. Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med 187 (1998) 1583-1598
36. Glunde K., Guggino S.E., Solaiyappan M., Pathak A.P., Ichikawa Y., and Bhujwalla Z.M. Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia 5 (2003) 533-545
37. Szakacs G., and Gottesman M.M. Comparing solid tumors with cell lines: implications for identifying drug resistance genes in cancer. Mol Interv 4 (2004) 323-325
38. Kang S.W., and Bae Y.H. Cryopreservable and tumorigenic three-dimensional tumor culture in porous poly(lactic-co-glycolic acid) microsphere. Biomaterials 30 (2009) 4227-4232