Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 22, 2012, Pages 8540-8545

  Peng, Chao ^a   Pu, Jin Yue ^a   Song, Li Qiang ^a   Jian, Xiao Hong ^a   Tang, Man Cheng ^a   Tang, Gong Li ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Fructose 6 phosphate; Primary metabolism; Secondary metabolism; Xylulose 5 phosphate

Indexed keywords

ACYL CARRIER PROTEIN; ANTINEOPLASTIC ANTIBIOTIC; GLYCOLALDEHYDE DEHYDROGENASE; KETOSE; NAPHTHYRIDINOMYCIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; QUINOCARCIN; THIOCTIC ACID; TRABECTEDIN; TRANSKETOLASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG SYNTHESIS; PRIORITY JOURNAL; STAPHYLOCOCCUS;

ACYL CARRIER PROTEIN; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KETOSES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; MUTATION; NAPHTHYRIDINES; PEPTIDE SYNTHASES; PEPTIDES; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES; SUBSTRATE SPECIFICITY; TETRAHYDROISOQUINOLINES; TRANSKETOLASE;

EID: 84861914244     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204232109     Document Type: Article

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