Characterization of the saframycin a gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner

Journal of Bacteriology

Volumn 190, Issue 1, 2008, Pages 251-263

  Li, Lei ^a   Deng, Wei ^a   Song, Jie ^a   Ding, Wei ^a   Zhao, Qun Fei ^a   Peng, Chao ^a   Song, Wei Wen ^a   Tang, Gong Li ^a   Liu, Wen ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BACTERIAL ENZYME; CONTIG; ISOQUINOLINE DERIVATIVE; NONRIBOSOMAL PEPTIDE SYNTHETASE; SAFRACIN B; SAFRAMYCIN A; SAFRAMYCIN MX1; SAFRAMYCIN Y3; TETRAHYDROISOQUINOLINE; TETRAPEPTIDE; TRABECTEDIN; UNCLASSIFIED DRUG;

ADENYLATION; ARTICLE; COMBINATORIAL CHEMISTRY; DRUG ISOLATION; DRUG POTENCY; ENZYME REGULATION; ENZYME SUBSTRATE; GENE CLUSTER; GENE LOCATION; GENE STRUCTURE; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STREPTOMYCES LAVENDULAE; STREPTOMYCES LAVENDULAE NRRL11002;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; DNA, BACTERIAL; GENOMIC LIBRARY; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OLIGOPEPTIDES; OPEN READING FRAMES; PEPTIDE FRAGMENTS; PEPTIDE SYNTHASES; PLASMIDS; PSEUDOMONAS FLUORESCENS; STREPTOMYCES;

PSEUDOMONAS FLUORESCENS; STREPTOMYCES LAVENDULAE;

EID: 37549065124     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00826-07     Document Type: Article

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