Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 39, 2006, Pages 14349-14354

  Chan, Yolande A ^a   Boyne II, Michael T ^b   Podevels, Angela M ^a   Klimowicz, Amy K ^a   Handelsman, Jo ^a   Kelleher, Neil L ^b   Thomas, Michael G ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Antibiotics; Combinatorial biosynthesis

Indexed keywords

ACYL CARRIER PROTEIN; AMINOMALONYL ACYL CARRIER PROTEIN; ANTIBIOTIC AGENT; ETHYLMALONYL COENZYME A; HYDROXYMALONYL ACYL CARRIER PROTEIN; MALONIC ACID DERIVATIVE; MALONYL COENZYME A; METHOXYMALONYL ACYL CARRIER PROTEIN; METHYLMALONYLCOENZYME A; POLYKETIDE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; ZWITTERMICIN A;

ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS;

ACYL CARRIER PROTEIN; APOPROTEINS; BACILLUS CEREUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; GENES, BACTERIAL; MALONATES; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYKETIDE SYNTHASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33749249749     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603748103     Document Type: Article

References (28)

1. Rawlings BJ (2001) Nat Prod Rep 18:231-281.
2. McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, Ashley G (1999) Proc Natl Acad Sci USA 96:1846-1851.
3. Emmert EAB, Klimowicz AK, Thomas MG, Handelsman J (2004) Appl Environ Microbiol 70:104-113.
4. Wu K, Chung L, Revill WP, Katz L, Reeves CD (2000) Gene 251:81-90.
5. Rascher A, Hu Z, Viswanathan N, Schirmer A, Reid R, Nierman WC, Lewis M, Hutchinson CR (2003) FEMS Microbiol Lett 218:223-230.
6. Rascher A, Hu Z, Buchanan GO, Reid R, Hutchinson CR (2005) Appl Environ Microbiol 71:4862-4871.
7. Carroll BJ, Moss SJ, Bai L, Kato Y, Toelzer S, Yu T-W, Floss HG (2002) J Am Chem Soc 124:4176-4177.
8. Ligon J, Hill S, Beck J, Zirkle R, Molnar I, Zawodny J, Money S, Schupp T (2002) Gene 285:257-267.
9. Watanabe K, Khosla C, Stroud RM, Tsai S-C (2003) J Mol Biol 334:435-444.
10. Kato Y, Bai L, Xue Q, Revill WP, Yu T-W, Floss HG (2002) J Am Chem Soc 124:5268-5269.
11. Rodriguez E, Ward S, Fu H, Revill WP, McDaniel R, Katz L (2004) Appl Microbiol Biotechnol 66:85-91.
12. Stachelhaus T, Marahiel MA (1995) J Biol Chem 270:6163-6169.
13. Quadri LE, Weinreb PH, Lei M, Nakano MM, Zuber P, Walsh CT (1998) Biochemistry 37:1585-1595.
14. Walton LJ, Corre C, Challis GL (2006) J Ind Microbiol Biotechnol 33:105-120.
15. Collet J-F, Stroobant V, Pirard M, Delpierre G, Van Schaftingen E (1998) J Biol Chem 273:14107-14112.
16. Cho H, Wang W, Kim R, Yokota H, Damo S, Kim SH, Wemmer D, Kustu S, Yan D (2001) Proc Natl Acad Sci USA 98:8525-8530.
17. Wang W, Kim R, Jancarik J, Yokota H, Kim SH (2001) Structure (London) 9:65-71.
18. Matthew M, Neuberger A (1963) Biochem J 87:601-612.
19. Ciciliato I, Corti E, Sarubbi E, Stefanelli S, Gastaldo L, Montanini N, Kurz M, Losi D, Marinelli F, Selva E (2004) J Antibiot 57:210-217.
20. Haydock SF, Aparicio JF, Molnar I, Schwecke T, Khaw LE, Konig A, Marsden AF, Galloway IS, Staunton J, Leadlay PF (1995) FEBS Lett 374:246-248.
21. Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C (2003) J Biol Chem 278:42020-42026.
22. Thomas MG, Burkart MD, Walsh CT (2002) Chem Biol 9:171-184.
23. Patrie SM, Charlebois JP, Whipple D, Kelleher NL, Hendrickson CL, Quinn JP, Marshall AG, Mukhopadhyay B (2004) J Am Soc Mass Spectrom 15:1099-1108.
24. Wang TC, Ricca TL, Marshall AG (1986) Anal Chem 58:2935-2938.
25. Little DP, Speir JP, Senko MW, O'Connor PB, McLafferty FW (1994) Anal Chem 66:2809-2815.
26. Horn DM, Zubarev RA, McLafferty FW (2000) J Am Soc Mass Spectrom 11:320-332.
27. Taylor GK, Kim YB, Forbes AJ, Meng F, McCarthy R, Kelleher NL (2003) Anal Chem 75:4081-4086.
28. Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL (2006) J Am Chem Soc 128:10386-10387.