Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis

Journal of Biological Chemistry

Volumn 287, Issue 7, 2012, Pages 5112-5121

  Tang, Man Cheng ^a   Fu, Cheng Yu ^a,b   Tang, Gong Li ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b Shaanxi Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR ANTIBIOTICS; BIOCHEMICAL ASSAY; BIOSYNTHETIC PATHWAY; CORE STRUCTURE; HEME BINDING; HEME PEROXIDASE; HETEROLOGOUS EXPRESSION; HYPOTHETICAL PROTEIN; IN-VITRO; KINETIC STUDY; MAGNETIC CIRCULAR DICHROISMS; MECHANISTIC STUDIES; METHYLTRANSFERASES; REGIO-SELECTIVE; TETRAHYDROISOQUINOLINES; WILD TYPES;

AMINO ACIDS; AROMATIC COMPOUNDS; BIOCHEMISTRY; CATALYSIS; HYDROGEN PEROXIDE; HYDROXYLATION; PORPHYRINS;

BIOSYNTHESIS;

3 HYDROXY 5 METHYL O METHYLTYROSINE; 3 HYDROXY 5 METHYLTYROSINE; AMINO ACID; HEME; PEROXIDASE; SAFRAMYCIN A; SAFRAMYCIN B; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME PURIFICATION; ENZYME SPECIFICITY; HYDROXYLATION; METHYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; BACTERIAL OUTER MEMBRANE PROTEINS; CATALYSIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROXYLATION; ISOQUINOLINES; METHYLTYROSINES; PEROXIDASE;

EID: 84856866295     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.306316     Document Type: Article

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