CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas

Cancer Research

Volumn 65, Issue 3, 2005, Pages 815-821

  Young, Hwa Soung ^a   Jong, Woo Lee ^a   Su, Young Kim ^a   Jang, Jin ^a   Yong, Gyu Park ^a   Won, Sang Park ^a   Suk, Woo Nam ^a   Jung, Young Lee ^a   Nam, Jin Yoo ^a   Sug, Hyung Lee ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ACUTE LEUKEMIA; ARTICLE; BREAST CARCINOMA; CARCINOGENESIS; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; GENE INACTIVATION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MUTATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; STOMACH CARCINOMA; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; APOPTOSIS; CASPASE 8; CASPASES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MUTATION; STOMACH NEOPLASMS;

EID: 13444309090     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Reed JC. Mechanisms of apoptosis. Am J Pathol 2000;39:1415-30.
2. Nagata S. Apoptosis by death factor. Cell 1997;88:355-65.
3. Nicholson DW. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 1999;6:1028-42.
4. Kumar S. Mechanisms mediating caspase activation in cell death. Cell Death Differ 1999;6:1060-6.
5. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
6. McDonnell TJ, Deane N, Platt FM, et al. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989;57:79-88.
7. Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997;275:967-9.
8. Lee SH, Shin MS, Park WS, et al. Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene 1999;18:3754-60.
9. Lee SH, Shin MS, Kim HS, et al. Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers. Cancer Res 1999;59:5683-6.
10. Shin MS, Kim HS, Kang CS, et al. Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas. Blood 2002;99:4094-9.
11. Soung YH, Lee JW, Kim HS, et al. Inactivating mutations of CASPASE-7 gene in human cancers. Oncogene 2003;22:8048-52.
12. Mandruzzato S, Brasseur F, Andry G, Boon T, van der Bruggen P. A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J Exp Med 1997;186:785-93.
13. Takita J, Yang HW, Chen YY, et al. Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene 2001; 20:4424-32.
14. Liu B, Peng D, Lu Y, Jin W, Fan Z. A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity. J Biol Chem 2002;277:30159-64.
15. Kim HS, Lee JW, Soung YH, et al. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003;125:708-15.
16. Lee JY, Dong SM, Kim SY, Yoo NJ, Lee SH, Park WS. A simple, precise and economical microdissection technique for analysis of genomic DNA from archival tissue sections. Virchows Arch 1998;433:305-9.
17. Boldin MP, Goncharov TM, Goltsev, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death. Cell 1996;85:803-15.
18. Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996;85:817-27.
19. Krawczak M, Reiss J, Cooper DN. The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: cause and consequences. Hum Genet 1992;90:41-54.
20. Watt W, Koeplinger KA, Mildner AM, Heinrikson RL, Tomasselli AG, Watenpaugh KD. The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure Fold Des 1999;7:1135-43.
21. Park WS, Oh RR, Kim YS, et al. Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer. J Pathol 2001;193:162-8.
22. Nishizuka S, Tamura G, Terashima M, Satodate R. Loss of heterozygosity during the development and progression of differentiated adenocarcinoma of the stomach. J Pathol 1998;185:38-43.
23. Bae JM, Won YJ, Jung KW, Park JG. Annual report of the Korea Central Cancer Registry Program 2000: based on registered data from 131 hospitals. Cancer Res Treat 2002;34:77-83.