Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation

Molecular Nutrition and Food Research

Volumn 56, Issue 5, 2012, Pages 797-809

  Han, Eun Hee ^a   Kim, Hyung Gyun ^a   Choi, Jae Ho ^a   Jang, Yin Jin ^b   Lee, Sang Seop ^b   Kwon, Kwang Il ^a   Kim, Eunyoung ^a   Noh, Kyeumhan ^c   Jeong, Tae Cheon ^c   Hwang, Yong Pil ^d   Chung, Young Chul ^d   Kang, Wonku ^c   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Inje University College of Medicine   (South Korea)

^c Yeungnam University   (South Korea)

^d Korea International University   (South Korea)

Author keywords

C EBP ; Capsaicin; CYP3A4; Food drug interactions; PXR

Indexed keywords

CAPSAICIN; CCAAT ENHANCER BINDING PROTEIN BETA; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; DEHYDRONIFEDIPINE; DRUG DERIVATIVE; NIFEDIPINE; PREGNANE X RECEPTOR; PROTEIN KINASE B; STEROID RECEPTOR; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ANIMAL; ARTICLE; BLOOD; CELL STRAIN HEPG2; DRUG DETOXIFICATION; DRUG EFFECT; FOOD DRUG INTERACTION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER; MALE; METABOLISM; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; CAPSAICIN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CYTOCHROME P-450 CYP3A; FOOD-DRUG INTERACTIONS; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; LIVER; MALE; METABOLIC DETOXICATION, DRUG; NIFEDIPINE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; TRPV CATION CHANNELS; UP-REGULATION;

CAPSICUM FRUTESCENS; RATTUS;

EID: 84861715347     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100697     Document Type: Article

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