-
1
-
-
81055144784
-
Autophagy: renovation of cells and tissues
-
Mizushima N., Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011, 147:728-741.
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
2
-
-
77950228925
-
Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview
-
Mehrpour M., Esclatine A., Beau I., Codogno P. Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview. Am. J. Physiol. Cell Physiol. 2010, 298:C776-C785.
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.298
-
-
Mehrpour, M.1
Esclatine, A.2
Beau, I.3
Codogno, P.4
-
4
-
-
77951220669
-
Role of autophagy in suppression of inflammation and cancer
-
White E., Karp C., Strohecker A.M., Guo Y., Mathew R. Role of autophagy in suppression of inflammation and cancer. Curr. Opin. Cell Biol. 2010, 22:212-217.
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 212-217
-
-
White, E.1
Karp, C.2
Strohecker, A.M.3
Guo, Y.4
Mathew, R.5
-
5
-
-
51449085299
-
The role of autophagy in mammalian development: cell makeover rather than cell death
-
Cecconi F., Levine B. The role of autophagy in mammalian development: cell makeover rather than cell death. Dev. Cell 2008, 15:344-357.
-
(2008)
Dev. Cell
, vol.15
, pp. 344-357
-
-
Cecconi, F.1
Levine, B.2
-
6
-
-
56749170677
-
Autophagic cell death: the story of a misnomer
-
Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol. 2008, 9:1004-1010.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 1004-1010
-
-
Kroemer, G.1
Levine, B.2
-
7
-
-
79955677000
-
Autophagic cell death: Loch Ness monster or endangered species?
-
Shen H.M., Codogno P. Autophagic cell death: Loch Ness monster or endangered species?. Autophagy 2011, 7.
-
(2011)
Autophagy
, vol.7
-
-
Shen, H.M.1
Codogno, P.2
-
8
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
Komatsu M., Waguri S., Ueno T., Iwata J., Murata S., Tanida I., Ezaki J., Mizushima N., Ohsumi Y., Uchiyama Y., Kominami E., Tanaka K., Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 2005, 169:425-434.
-
(2005)
J. Cell Biol.
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
-
9
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., Ohsumi Y., Tokuhisa T., Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
10
-
-
7744235672
-
Death by design: apoptosis, necrosis and autophagy
-
Edinger A.L., Thompson C.B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 2004, 16:663-669.
-
(2004)
Curr. Opin. Cell Biol.
, vol.16
, pp. 663-669
-
-
Edinger, A.L.1
Thompson, C.B.2
-
11
-
-
29944438881
-
Necrotic death as a cell fate
-
Zong W.X., Thompson C.B. Necrotic death as a cell fate. Genes Dev. 2006, 20:1-15.
-
(2006)
Genes Dev.
, vol.20
, pp. 1-15
-
-
Zong, W.X.1
Thompson, C.B.2
-
12
-
-
77952236200
-
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features
-
Berghe T.V., Vanlangenakker N., Parthoens E., Deckers W., Devos M., Festjens N., Guerin C.J., Brunk U.T., Declercq W., Vandenabeele P. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ. 2010, 17:922-930.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 922-930
-
-
Berghe, T.V.1
Vanlangenakker, N.2
Parthoens, E.3
Deckers, W.4
Devos, M.5
Festjens, N.6
Guerin, C.J.7
Brunk, U.T.8
Declercq, W.9
Vandenabeele, P.10
-
13
-
-
0020405571
-
Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance
-
Searle J., Kerr J.F., Bishop C.J. Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance. Pathol. Annu. 1982, 17(Pt 2):229-259.
-
(1982)
Pathol. Annu.
, vol.17
, Issue.PART 2
, pp. 229-259
-
-
Searle, J.1
Kerr, J.F.2
Bishop, C.J.3
-
14
-
-
34250753161
-
Cell death modalities: classification and pathophysiological implications
-
Galluzzi L., Maiuri M.C., Vitale I., Zischka H., Castedo M., Zitvogel L., Kroemer G. Cell death modalities: classification and pathophysiological implications. Cell Death Differ. 2007, 14:1237-1243.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1237-1243
-
-
Galluzzi, L.1
Maiuri, M.C.2
Vitale, I.3
Zischka, H.4
Castedo, M.5
Zitvogel, L.6
Kroemer, G.7
-
15
-
-
77955271788
-
The molecular regulation of programmed necrotic cell injury
-
Moquin D., Chan F.K. The molecular regulation of programmed necrotic cell injury. Trends Biochem. Sci. 2010, 35:434-441.
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 434-441
-
-
Moquin, D.1
Chan, F.K.2
-
16
-
-
78349309166
-
Cyclophilin A release as a biomarker of necrotic cell death
-
Christofferson D.E., Yuan J. Cyclophilin A release as a biomarker of necrotic cell death. Cell Death Differ. 2010, 17:1942-1943.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 1942-1943
-
-
Christofferson, D.E.1
Yuan, J.2
-
17
-
-
34547105307
-
Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus
-
Ditsworth D., Zong W.X., Thompson C.B. Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J. Biol. Chem. 2007, 282:17845-17854.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17845-17854
-
-
Ditsworth, D.1
Zong, W.X.2
Thompson, C.B.3
-
18
-
-
77951251430
-
Necroptosis as an alternative form of programmed cell death
-
Christofferson D.E., Yuan J. Necroptosis as an alternative form of programmed cell death. Curr. Opin. Cell Biol. 2010, 22:263-268.
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 263-268
-
-
Christofferson, D.E.1
Yuan, J.2
-
19
-
-
42449123761
-
Expansion and evolution of cell death programmes
-
Degterev A., Yuan J. Expansion and evolution of cell death programmes. Nat. Rev. Mol. Cell Biol. 2008, 9:378-390.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 378-390
-
-
Degterev, A.1
Yuan, J.2
-
20
-
-
0031282499
-
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells
-
Vercammen D., Vandenabeele P., Beyaert R., Declercq W., Fiers W. Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. Cytokine 1997, 9:801-808.
-
(1997)
Cytokine
, vol.9
, pp. 801-808
-
-
Vercammen, D.1
Vandenabeele, P.2
Beyaert, R.3
Declercq, W.4
Fiers, W.5
-
21
-
-
81255195542
-
Programmed necrosis: backup to and competitor with apoptosis in the immune system
-
Han J., Zhong C.Q., Zhang D.W. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat. Immunol. 2011, 12:1143-1149.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1143-1149
-
-
Han, J.1
Zhong, C.Q.2
Zhang, D.W.3
-
22
-
-
77957105977
-
Molecular mechanisms of necroptosis: an ordered cellular explosion
-
Vandenabeele P., Galluzzi L., Vanden Berghe T., Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 2010, 11:700-714.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 700-714
-
-
Vandenabeele, P.1
Galluzzi, L.2
Vanden Berghe, T.3
Kroemer, G.4
-
23
-
-
5944233768
-
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
-
Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.L., Schneider P., Seed B., Tschopp J. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 2000, 1:489-495.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 489-495
-
-
Holler, N.1
Zaru, R.2
Micheau, O.3
Thome, M.4
Attinger, A.5
Valitutti, S.6
Bodmer, J.L.7
Schneider, P.8
Seed, B.9
Tschopp, J.10
-
24
-
-
33847051539
-
RIP1, a kinase on the crossroads of a cell's decision to live or die
-
Festjens N., Vanden Berghe T., Cornelis S., Vandenabeele P. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ. 2007, 14:400-410.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 400-410
-
-
Festjens, N.1
Vanden Berghe, T.2
Cornelis, S.3
Vandenabeele, P.4
-
25
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
Degterev A., Hitomi J., Germscheid M., Ch'en I.L., Korkina O., Teng X., Abbott D., Cuny G.D., Yuan C., Wagner G., Hedrick S.M., Gerber S.A., Lugovskoy A., Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 2008, 4:313-321.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'en, I.L.4
Korkina, O.5
Teng, X.6
Abbott, D.7
Cuny, G.D.8
Yuan, C.9
Wagner, G.10
Hedrick, S.M.11
Gerber, S.A.12
Lugovskoy, A.13
Yuan, J.14
-
26
-
-
66449133280
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
-
Cho Y.S., Challa S., Moquin D., Genga R., Ray T.D., Guildford M., Chan F.K. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123.
-
(2009)
Cell
, vol.137
, pp. 1112-1123
-
-
Cho, Y.S.1
Challa, S.2
Moquin, D.3
Genga, R.4
Ray, T.D.5
Guildford, M.6
Chan, F.K.7
-
27
-
-
66749183275
-
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
-
He S., Wang L., Miao L., Wang T., Du F., Zhao L., Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009, 137:1100-1111.
-
(2009)
Cell
, vol.137
, pp. 1100-1111
-
-
He, S.1
Wang, L.2
Miao, L.3
Wang, T.4
Du, F.5
Zhao, L.6
Wang, X.7
-
28
-
-
67650812332
-
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
-
Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., Dong M.Q., Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.
-
(2009)
Science
, vol.325
, pp. 332-336
-
-
Zhang, D.W.1
Shao, J.2
Lin, J.3
Zhang, N.4
Lu, B.J.5
Lin, S.C.6
Dong, M.Q.7
Han, J.8
-
29
-
-
33644862368
-
JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species
-
Shen H.M., Liu Z.G. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic. Biol. Med. 2006, 40:928-939.
-
(2006)
Free Radic. Biol. Med.
, vol.40
, pp. 928-939
-
-
Shen, H.M.1
Liu, Z.G.2
-
30
-
-
0033214236
-
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
-
Lin Y., Devin A., Rodriguez Y., Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 1999, 13:2514-2526.
-
(1999)
Genes Dev.
, vol.13
, pp. 2514-2526
-
-
Lin, Y.1
Devin, A.2
Rodriguez, Y.3
Liu, Z.G.4
-
31
-
-
80755132824
-
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation
-
Bonnet M.C., Preukschat D., Welz P.S., van Loo G., Ermolaeva M.A., Bloch W., Haase I., Pasparakis M. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 2011, 35:572-582.
-
(2011)
Immunity
, vol.35
, pp. 572-582
-
-
Bonnet, M.C.1
Preukschat, D.2
Welz, P.S.3
van Loo, G.4
Ermolaeva, M.A.5
Bloch, W.6
Haase, I.7
Pasparakis, M.8
-
32
-
-
79960922705
-
CIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
-
Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., Cain K., MacFarlane M., Hacker G., Leverkus M. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 2011, 43:449-463.
-
(2011)
Mol. Cell
, vol.43
, pp. 449-463
-
-
Feoktistova, M.1
Geserick, P.2
Kellert, B.3
Dimitrova, D.P.4
Langlais, C.5
Hupe, M.6
Cain, K.7
MacFarlane, M.8
Hacker, G.9
Leverkus, M.10
-
33
-
-
79952780505
-
Functional complementation between FADD and RIP1 in embryos and lymphocytes
-
Zhang H., Zhou X., McQuade T., Li J., Chan F.K., Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011, 471:373-376.
-
(2011)
Nature
, vol.471
, pp. 373-376
-
-
Zhang, H.1
Zhou, X.2
McQuade, T.3
Li, J.4
Chan, F.K.5
Zhang, J.6
-
34
-
-
79952811804
-
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
-
Kaiser W.J., Upton J.W., Long A.B., Livingston-Rosanoff D., Daley-Bauer L.P., Hakem R., Caspary T., Mocarski E.S. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011, 471:368-372.
-
(2011)
Nature
, vol.471
, pp. 368-372
-
-
Kaiser, W.J.1
Upton, J.W.2
Long, A.B.3
Livingston-Rosanoff, D.4
Daley-Bauer, L.P.5
Hakem, R.6
Caspary, T.7
Mocarski, E.S.8
-
35
-
-
77951171023
-
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
-
Bonapace L., Bornhauser B.C., Schmitz M., Cario G., Ziegler U., Niggli F.K., Schafer B.W., Schrappe M., Stanulla M., Bourquin J.P. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J. Clin. Invest. 2010, 120:1310-1323.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1310-1323
-
-
Bonapace, L.1
Bornhauser, B.C.2
Schmitz, M.3
Cario, G.4
Ziegler, U.5
Niggli, F.K.6
Schafer, B.W.7
Schrappe, M.8
Stanulla, M.9
Bourquin, J.P.10
-
36
-
-
80655144753
-
Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy
-
Farkas T., Daugaard M., Jaattela M. Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy. J. Biol. Chem. 2011, 286:38904-38912.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 38904-38912
-
-
Farkas, T.1
Daugaard, M.2
Jaattela, M.3
-
37
-
-
55949083821
-
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
-
Bell B.D., Leverrier S., Weist B.M., Newton R.H., Arechiga A.F., Luhrs K.A., Morrissette N.S., Walsh C.M. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:16677-16682.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 16677-16682
-
-
Bell, B.D.1
Leverrier, S.2
Weist, B.M.3
Newton, R.H.4
Arechiga, A.F.5
Luhrs, K.A.6
Morrissette, N.S.7
Walsh, C.M.8
-
38
-
-
77955609495
-
Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis
-
Osborn S.L., Diehl G., Han S.J., Xue L., Kurd N., Hsieh K., Cado D., Robey E.A., Winoto A. Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:13034-13039.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 13034-13039
-
-
Osborn, S.L.1
Diehl, G.2
Han, S.J.3
Xue, L.4
Kurd, N.5
Hsieh, K.6
Cado, D.7
Robey, E.A.8
Winoto, A.9
-
39
-
-
81455149975
-
TNFalpha-induced necroptosis and autophagy via suppression of the p38-NF-kappaB survival pathway in L929 Cells
-
Ye Y.C., Yu L., Wang H.J., Tashiro S., Onodera S., Ikejima T. TNFalpha-induced necroptosis and autophagy via suppression of the p38-NF-kappaB survival pathway in L929 Cells. J. Pharmacol. Sci. 2011, 117:160-169.
-
(2011)
J. Pharmacol. Sci.
, vol.117
, pp. 160-169
-
-
Ye, Y.C.1
Yu, L.2
Wang, H.J.3
Tashiro, S.4
Onodera, S.5
Ikejima, T.6
-
40
-
-
0032482169
-
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
-
Vercammen D., Beyaert R., Denecker G., Goossens V., Van Loo G., Declercq W., Grooten J., Fiers W., Vandenabeele P. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J. Exp. Med. 1998, 187:1477-1485.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1477-1485
-
-
Vercammen, D.1
Beyaert, R.2
Denecker, G.3
Goossens, V.4
Van Loo, G.5
Declercq, W.6
Grooten, J.7
Fiers, W.8
Vandenabeele, P.9
-
41
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., Baehrecke E.H., Lenardo M.J. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004, 304:1500-1502.
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehrecke, E.H.7
Lenardo, M.J.8
-
42
-
-
69449092724
-
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
-
Wu Y.T., Tan H.L., Huang Q., Ong C.N., Shen H.M. Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy 2009, 5:824-834.
-
(2009)
Autophagy
, vol.5
, pp. 824-834
-
-
Wu, Y.T.1
Tan, H.L.2
Huang, Q.3
Ong, C.N.4
Shen, H.M.5
-
43
-
-
43949085388
-
Autophagy plays a protective role during zVAD-induced necrotic cell death
-
Wu Y.T., Tan H.L., Huang Q., Kim Y.S., Pan N., Ong W.Y., Liu Z.G., Ong C.N., Shen H.M. Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 2008, 4:457-466.
-
(2008)
Autophagy
, vol.4
, pp. 457-466
-
-
Wu, Y.T.1
Tan, H.L.2
Huang, Q.3
Kim, Y.S.4
Pan, N.5
Ong, W.Y.6
Liu, Z.G.7
Ong, C.N.8
Shen, H.M.9
-
44
-
-
78650175369
-
ZVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated via the PKC-MAPKs-AP-1 pathway
-
Wu Y.T., Tan H.L., Huang Q., Sun X.J., Zhu X., Ong C.N., Shen H.M. zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated via the PKC-MAPKs-AP-1 pathway. Cell Death Differ. 2011, 18:26-37.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 26-37
-
-
Wu, Y.T.1
Tan, H.L.2
Huang, Q.3
Sun, X.J.4
Zhu, X.5
Ong, C.N.6
Shen, H.M.7
-
45
-
-
18944390248
-
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
-
Jagtap P., Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat. Rev. Drug Discov. 2005, 4:421-440.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 421-440
-
-
Jagtap, P.1
Szabo, C.2
-
46
-
-
77954274504
-
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets
-
Krishnakumar R., Kraus W.L. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol. Cell 2010, 39:8-24.
-
(2010)
Mol. Cell
, vol.39
, pp. 8-24
-
-
Krishnakumar, R.1
Kraus, W.L.2
-
47
-
-
0033598713
-
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
-
Ha H.C., Snyder S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13978-13982.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 13978-13982
-
-
Ha, H.C.1
Snyder, S.H.2
-
48
-
-
2642536197
-
Alkylating DNA damage stimulates a regulated form of necrotic cell death
-
Zong W.X., Ditsworth D., Bauer D.E., Wang Z.Q., Thompson C.B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev. 2004, 18:1272-1282.
-
(2004)
Genes Dev.
, vol.18
, pp. 1272-1282
-
-
Zong, W.X.1
Ditsworth, D.2
Bauer, D.E.3
Wang, Z.Q.4
Thompson, C.B.5
-
49
-
-
0037067317
-
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
-
Yu S.W., Wang H., Poitras M.F., Coombs C., Bowers W.J., Federoff H.J., Poirier G.G., Dawson T.M., Dawson V.L. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002, 297:259-263.
-
(2002)
Science
, vol.297
, pp. 259-263
-
-
Yu, S.W.1
Wang, H.2
Poitras, M.F.3
Coombs, C.4
Bowers, W.J.5
Federoff, H.J.6
Poirier, G.G.7
Dawson, T.M.8
Dawson, V.L.9
-
50
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
-
Hardie D.G. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 2007, 8:774-785.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
51
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
52
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 2008, 30:214-226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
53
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J., Kundu M., Viollet B., Guan K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 13:132-141.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
54
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., Vasquez D.S., Joshi A., Gwinn D.M., Taylor R., Asara J.M., Fitzpatrick J., Dillin A., Viollet B., Kundu M., Hansen M., Shaw R.J. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
Asara, J.M.11
Fitzpatrick, J.12
Dillin, A.13
Viollet, B.14
Kundu, M.15
Hansen, M.16
Shaw, R.J.17
-
55
-
-
34249784216
-
Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models
-
Albert J.M., Cao C., Kim K.W., Willey C.D., Geng L., Xiao D., Wang H., Sandler A., Johnson D.H., Colevas A.D., Low J., Rothenberg M.L., Lu B. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin. Cancer Res. 2007, 13:3033-3042.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3033-3042
-
-
Albert, J.M.1
Cao, C.2
Kim, K.W.3
Willey, C.D.4
Geng, L.5
Xiao, D.6
Wang, H.7
Sandler, A.8
Johnson, D.H.9
Colevas, A.D.10
Low, J.11
Rothenberg, M.L.12
Lu, B.13
-
56
-
-
61649093766
-
To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
-
Huang Q., Shen H.M. To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage. Autophagy 2009, 5:273-276.
-
(2009)
Autophagy
, vol.5
, pp. 273-276
-
-
Huang, Q.1
Shen, H.M.2
-
57
-
-
77749233738
-
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
-
Alexander A., Cai S.L., Kim J., Nanez A., Sahin M., MacLean K.H., Inoki K., Guan K.L., Shen J., Person M.D., Kusewitt D., Mills G.B., Kastan M.B., Walker C.L. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:4153-4158.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 4153-4158
-
-
Alexander, A.1
Cai, S.L.2
Kim, J.3
Nanez, A.4
Sahin, M.5
MacLean, K.H.6
Inoki, K.7
Guan, K.L.8
Shen, J.9
Person, M.D.10
Kusewitt, D.11
Mills, G.B.12
Kastan, M.B.13
Walker, C.L.14
-
58
-
-
58149380360
-
PARP-1 is involved in autophagy induced by DNA damage
-
Munoz-Gamez J.A., Rodriguez-Vargas J.M., Quiles-Perez R., Aguilar-Quesada R., Martin-Oliva D., de Murcia G., Menissier de Murcia J., Almendros A., Ruiz de Almodovar M., Oliver F.J. PARP-1 is involved in autophagy induced by DNA damage. Autophagy 2009, 5:61-74.
-
(2009)
Autophagy
, vol.5
, pp. 61-74
-
-
Munoz-Gamez, J.A.1
Rodriguez-Vargas, J.M.2
Quiles-Perez, R.3
Aguilar-Quesada, R.4
Martin-Oliva, D.5
de Murcia, G.6
Menissier de Murcia, J.7
Almendros, A.8
Ruiz de Almodovar, M.9
Oliver, F.J.10
-
59
-
-
77954623119
-
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD
-
Hwang J.W., Chung S., Sundar I.K., Yao H., Arunachalam G., McBurney M.W., Rahman I. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch. Biochem. Biophys. 2010, 500:203-209.
-
(2010)
Arch. Biochem. Biophys.
, vol.500
, pp. 203-209
-
-
Hwang, J.W.1
Chung, S.2
Sundar, I.K.3
Yao, H.4
Arunachalam, G.5
McBurney, M.W.6
Rahman, I.7
-
60
-
-
79960004073
-
Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K
-
Yang J.C., Lu M.C., Lee C.L., Chen G.Y., Lin Y.Y., Chang F.R., Wu Y.C. Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K. Free Radic. Biol. Med. 2011, 51:641-657.
-
(2011)
Free Radic. Biol. Med.
, vol.51
, pp. 641-657
-
-
Yang, J.C.1
Lu, M.C.2
Lee, C.L.3
Chen, G.Y.4
Lin, Y.Y.5
Chang, F.R.6
Wu, Y.C.7
-
61
-
-
77957599220
-
Poly(ADP-ribose) polymerase inhibition: "targeted" therapy for triple-negative breast cancer
-
Anders C.K., Winer E.P., Ford J.M., Dent R., Silver D.P., Sledge G.W., Carey L.A. Poly(ADP-ribose) polymerase inhibition: "targeted" therapy for triple-negative breast cancer. Clin. Cancer Res. 2010, 16:4702-4710.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 4702-4710
-
-
Anders, C.K.1
Winer, E.P.2
Ford, J.M.3
Dent, R.4
Silver, D.P.5
Sledge, G.W.6
Carey, L.A.7
-
62
-
-
51449113045
-
Targeted therapy for cancer using PARP inhibitors
-
Lord C.J., Ashworth A. Targeted therapy for cancer using PARP inhibitors. Curr. Opin. Pharmacol. 2008, 8:363-369.
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 363-369
-
-
Lord, C.J.1
Ashworth, A.2
|