Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model

Reproductive Toxicology

Volumn 33, Issue 4, 2012, Pages 468-490

  Loccisano, Anne E ^a   Campbell Jr , Jerry L ^a   Butenhoff, John L ^b   Andersen, Melvin E ^a   Clewell III, Harvey J ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b 3M COMPANY   (United States)

Author keywords

Gestation; Lactation; PBPK; Perfluoroalkyls; PFOA; PFOS; Physiologically based pharmacokinetic model

Indexed keywords

PERFLUOROOCTANE; PERFLUOROOCTANESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHEMICAL BINDING; ENVIRONMENTAL EXPOSURE; FEMALE; FETOTOXICITY; FETUS; FETUS RISK; HEALTH HAZARD; KIDNEY TUBULE ABSORPTION; LACTATION; MALE; NEWBORN; NONHUMAN; PLASMA HALF LIFE; POSTNATAL DEVELOPMENT; PREGNANCY; PRENATAL EXPOSURE; RAT; RISK ASSESSMENT; SENSITIVITY ANALYSIS; TISSUE DISTRIBUTION; TOXICITY TESTING; TOXICOKINETICS;

AGING; ALKANESULFONIC ACIDS; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL BLOOD; FLUOROCARBONS; GESTATIONAL AGE; LACTATION; LIVER; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; MILK; MODELS, BIOLOGICAL; OCTANOIC ACIDS; PLACENTA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; TISSUE DISTRIBUTION;

ANIMALIA; RATTUS;

EID: 84861532343     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.07.003     Document Type: Article

References (120)

1. Lau C., Thibodeaux J.R., Hanson R.G., Narotsky M.G., Rogers J.M., Lindstrom A.B., et al. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 2006, 90:510-518.
2. Trudel D., Horowitz L., Wormuth M., Scheringer M., Cousins I.T., Hungerbuhler K. Estimating consumer exposure to pfos and pfoa. Risk Anal 2008, 28:251-269.
3. Olsen G.W., Burris J.M., Ehresman D.J., Froehlich J.W., Seacat A.M., Butenhoff J.L., et al. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 2007, 115:1298-1305.
4. Emmett E.A., Shofer F.S., Zhang H., Freeman D., Desai C., Shaw L.M. Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources. J Occ Environ Med 2006, 48:759-770.
5. Olsen G.W., Butenhoff J.L., Zobel L.R. Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives. Reprod Toxicol 2009, 27:212-230.
6. Schecter A., Colacino J., Haffner D., Patel K., Opel M., Papke O., et al. Perfluorinated compounds, polychlorinated biphenyl, and organochlorine pesticide contamination in composite food samples from dallas, tx. Environ Health Perspect 2010, 118:357-362.
7. Washburn S.T., Bingman T.S., Braithwaite S.K., Buck R.C., Buxton L.W., Clewell H.J., et al. Exposure assessment and risk characterization for perfluorooctanoate in selected consumer articles. Environ Sci Technol 2005, 39:3904-3910.
8. Calafat A.M., Wong L.-Y., Kuklenyik Z., Reidy J.A., Needham L.L. Polyfluoroalkyl chemicals in the U.S. Population: data from the national health and nutrition examination survey (nhanes) 2003-2004 and comparisons with nhanes 1999-2000. Environ Health Perspect 2007, 115:1596-1602.
9. 14c]perfluorooctanesulfonate. Fund Appl Toxicol 1984, 4:972-976.
10. Kuslikis B.I., Vanden Heuvel J.P., Peterson R.E. Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme a formation in male and female rats. J Biochem Toxicol 1992, 7:25-29.
11. Ophaug R.H., Singer L. Metabolic handling of perfluorooctanoic acid in rats. Proc Soc Exp Biol Med 1980, 163:19-23.
12. Vanden Heuvel J.P., Kuslikis B.I., Rafelghem M.J., Peterson R.E. Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats. J Biochem Toxicol 1991, 6:83-92.
13. Han X., Snow T.A., Kemper R.A., Jepson G.W. Binding of perfluorooctanoic acid to rat and human plasma proteins. Chem Res Toxicol 2003, 16:775-781.
14. Jones P.D., Hu W., De Coen W., Newsted J.L., Giesy J.P. Binding of perfluorinated fatty acids to serum proteins. Environ Toxicol Chem 2003, 22:2639-2649.
15. Kerstner-Wood C, Coward L, Gorman G. Protein binding of perfluorobutane sulfonate, perfluorohexane sulfonate, perfluorooctane sulfonate, and perfluorooctanoate to plasma (human, rat, and monkey) and various human-derived plasma protein fractions. Southern Research Corporation; 2003.
16. MacManus-Spencer L.A., Tse M.L., Hebert P.C., Bischel H.N., Luthy R.G. Binding of perfluorocarboxylates to serum albumin: a comparison of analytical methods. Anal Chem 2010, 82:974-981.
17. Kemper R. Perfluooctanoic acid: toxicokinetics in the rat. Project ID: DuPont 7473; USEPA Public Docket Adminstrative Record AR-226-1499; 2003.
18. Noker P, Gorman G. A pharmacokinetic study of potassium perfluorooctanesulfonate in the cynomolgus monkey. Southern Research Institute Study ID: 9921.6. Administrative Record AR-226-1356; 2003.
19. Seacat A.M., Thomford P.J., Hansen K.J., Olsen G.W., Case M.T., Butenhoff J.L. Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys. Toxicol Sci 2002, 68:249-264.
20. Hinderliter P.M., Han X., Kennedy G.L., Butenhoff J.L. Age effect on perfluorooctanoate (pfoa) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (apfo). Toxicology 2006, 225:195-203.
21. 3M. Unpublished data; 2009.
22. Benskin J.P., De Silva A.O., Martin L.J., Arsenault G., McCrindle R., Riddell N., et al. Disposition of perfluorinated acid isomers in Sprague-Dawley rats; part 1: single dose. Environ Toxicol Chem 2009, 28:542-554.
23. Loveless S.E., Finlay C., Everds N.E., Frame S.R., Gillies P.J., O'Connor J.C., et al. Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (apfo). Toxicology 2006, 220:203-217.
24. Andersen M.E., Clewell H.J., Tan Y-M., Butenhoff J.L., Olsen G. Pharmacokinetic modeling of saturable, renal absorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives. Toxicology 2006, 227:156-164.
25. Tan Y.-M., Clewell H.J., Andersen M.E. Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis. Toxicol Lett 2008, 177:38-47.
26. Kudo N., Katakura M., Sato Y., Kawashima Y. Sex hormone-regulated renal transport of perfluorooctanoic acid. Chem Biol Interact 2002, 139:310-316.
27. Weaver Y.M., Ehresman D.J., Butenhoff J.L., Hagenbuch B. Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicol Sci 2009, 113:305-314.
28. Katakura M., Kudo N., Tsuda T., Hibino Y., Mitsumoto A., Kawashima Y. Rat organic anion transporter 3 and organic anion transporting polypeptide 1 mediate perfluorooctanoic acid transport. J Health Sci 2007, 53:77-83.
29. Kato Y., Kuge K., Kusuhara H., Meier P.J., Sugiyama Y. Gender differences in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther 2002, 302:483-489.
30. Yang C., Glover K.P., Han X. Organic anion transporting polypeptide (oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of oatp1a1 in renal elimination of perfluorocarboxylates in rats. Toxicol Lett 2009, 190:163-171.
31. Nakagawa H., Terada T., Harada K.H., Hitomi T., Inoue K., Inui K-i., et al. Human organic anion transporter hoat4 is a transporter of perfluorooctanoic acid. Basic Clin Pharmacol Toxicol 2009, 105:136-138.
32. Yang C., Glover K.P., Han X. Characterization of cellular uptake of perfluoroctanoate via organic anion-transporting polypeptide 1a2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renl reabsorption of perfluorocarboxylates. Toxicol Sci 2010, 117:294-302.
33. Case M.T., York R.G., Christian M.S. Rat and rabbit oral developmental toxicology studies with two perfluorinated compounds. Int J Toxicol 2001, 20:101-109.
34. Grasty R.C., Bjork J.A., Wallace K.B., Lau C., Rogers J.M. Effects of prenatal perfluorooctane sulfonate (pfos) exposure on lung maturation in the perinatal rat. Birth Defects Res Part B 2005, 74:405-416.
35. Lau C., Thibodeaux J.R., Hanson R.G., Rogers J.M., Grey B.E., Stanton M.E., et al. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. Ii: Postnatal evaluation. Toxicol Sci 2003, 74:382-392.
36. Luebker D.J., Case M.T., York R.G., Moore J.A., Hansen K.J., Butenhoff J.L. Two-generation reproduction and cross-foster studies of perfluorooctanesulfonate (pfos) in rats. Toxicology 2005, 215:126-148.
37. Luebker D.J., York R.G., Hansen K.J., Moore J.A., Butenhoff J.L. Neonatal mortality from in utero exposure to perfluorooctanesulfonate (pfos) in sprague-dawley rats: dose-response, and biochemical and pharmacokinetic parameters. Toxicology 2005, 215:149-169.
38. Thibodeaux J.R., Hanson R.G., Rogers J.M., Grey B.E., Barbee B.D., Richards J.H., et al. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: Maternal and prenatal evaluations. Toxicol Sci 2003, 74:369-381.
39. Yu W.-G., Liu W., Jin Y.-H., Liu W.-H., Wang F.-Q., Liu L., Nakayama S.F. Prenatal and postnatal impact of perfluorooctane sulfonate (pfos) on rat development: a cross-foster study on chemical burden and thyroid hormone system. Environ Sci Technol 2009, 43:8416-8422.
40. Wang F., Liu W., Jin Y., Dai J., Yu W., Liu X., et al. Transcriptional effects of prenatal and neonatal exposure to pfos in the developing rat brain. Environ Sci Technol 2010, 44:1847-1853.
41. Butenhoff J.L., Ehresman D.J., Chang S.-C., Parker G.A., Stump D.G. Gestational and lactational exposure to potassium perfluorooctanesulfonate (k+pfos) in rats: developmental neurotoxicity. Reprod Toxicol 2009, 27:319-330.
42. White S.S., Calafat A.M., Kuklenyik Z., Villanueva L., Zehr R.D., Helfant L., et al. Gestational pfoa exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicol Sci 2007, 96:133-144.
43. Wolf C.J., Fenton S.E., Schmid J.E., Calafat A.M., Kuklenyik Z., Bryant X.A., et al. Developmental toxicity of perfluorooctanoic acid in the cd-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci 2007, 95:462-473.
44. Andersen M.E., Butenhoff J.L., Chang S.-C., Farrar D.G., Kennedy G.L., Lau C., et al. Perfluoroalkyl acids and related chemistries - toxicokinetics and modes of action. Toxicol Sci 2008, 102:3-14.
45. Gonzalez F.J., Shah Y.M. Ppar-a: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 2008, 246:2-8.
46. Lake B.G. Species differences in the hepatic effects of inducers of cyp2b and cyp4a subfamily forms: relationship to rodent liver tumour formation. Xenobiotica 2009, 39:582-596.
47. Abbott B.D., Wolf C.J., Das K.P., Zehr R.D., Schmid J.E., Lindstrom A.B., et al. Developmental toxicity of perfluorooctane sulfonate (pfos) is not dependent on expression of peroxisome proliferator activated receptor-alpha (pparα) in the mouse. Reprod Toxicol 2009, 27:258-265.
48. Abbott B.D., Wolf C.J., Schmid J.E., Das K.P., Zehr R.D., Helfant L., et al. Perfluorooctanoic acid-induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator-activated receptor-alpha. Toxicol Sci 2007, 98:571-581.
49. Karrman A., Ericson I., Van Bavel B., Darnerud P.O., Aune M., Glynn A., et al. Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996-2004, in sweden. Environ Health Perspect 2007, 115:226-230.
50. Kuklenyik Z., Reich J.A., Tully J.S., Needham L.L., Calafat A.M. Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk. Environ Sci Technol 2004, 38:3698-3704.
51. von Ehrenstein O., Fenton S.E., Kato K., Kuklenyik Z., Calafat A.M., Hines E.P. Polyfluoroalkyl chemicals in the serum and milk of breastfeeding women. Reprod Toxicol 2009, 27:239-245.
52. Sundstrom M., Ehresman D.J., Bignert A., Butenhoff J.L., Olsen G.W., Chang C.-H., Bergman A. A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pool human milk samples from stockholm, sweden. Environ Int 2011, 37:178-183.
53. Apelberg B.J., Goldman L.R., Calafat A.M., Herbstman J.B., Kuklenyik Z., Heidler J., et al. Determinants of fetal exposure to polyfluoroalkyl compounds in baltimore, maryland. Environ Sci Technol 2007, 41:3891-3897.
54. Monroy R., Morrison K., Teo K., Atkinson S., Kubwabo C., Stewart B., et al. Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environ Res 2008, 108:56-62.
55. Fei C., McLaughlin J.K., Tarone R.E., Olsen J. Perfluorinated chemicals and fetal growth: a study within the danish national birth cohort. Environ Health Perspect 2007, 115:1677-1682.
56. Midasch O., Drexler H., Hart N., Beckmann M.W. Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study. Int Arch Occup Environ Health 2007, 80:643-648.
57. Hinderliter P.M., Mylchreest E., Gannon S.A., Butenhoff J.L., Kennedy G.L. Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats. Toxicology 2005, 211:139-148.
58. Loccisano AE, Campbell JL, Butenhoff JL, Andersen ME, Clewell HJ. Comparison & evaluation of pharmacokinetics of pfoa and pfos in the adult rat using a physiologically based pharmacokinetic model. Reprod Toxicol; in press.
59. Chang S.-C., Ehresman D.J., Bjork J.A., Wallace K.B., Parker G.A., Stump D.G., et al. Gestational and lactational exposure to potassium perfluorooctanesulfonate (k+pfos) in rats: toxicokinetics, thryroid hormone status, and related gene expression. Reprod Toxicol 2009, 27:287-399.
60. AEgis. Acslx. The AEgis Technologies Group, Inc., Huntsville, AL; 2009.
61. Henning S.J. Postnatal development: coordination of feeding, digestion, and metabolism. Am J Physiol Gastrointest Liver Physiol 1981, 241:G199-G214.
62. Lau C., Butenhoff J.L., Rogers J.M. The developmental toxicity of perfluoroalkyl acids and their derivatives. Toxicol Appl Pharmacol 2004, 198:231-241.
63. USEPA. Draft risk assessment of the potential human health effects associated with exposure to perfluorooctanoic acid and its salts; 2005.
64. Luebker D.J., Hansen K.J., Bass N.M., Butenhoff J.L., Seacat A.M. Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology 2002, 176:175-185.
65. Loccisano A.E., Campbell J.L., Andersen M.E., Clewell H.J. Evaluation and prediction of pharmacokinetics of pfoa and pfos in the monkey and human using a pbpk model. Reg Toxicol Pharmacol 2011, 59:157-175.
66. Kudo N., Kawashima Y. Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals. J Toxicol Sci 2003, 28:49-57.
67. Lau C., Anitole K., Hodes C., Lai D., Pfahles-Hutchens A., Seed J. Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 2007, 99:366-394.
68. Stock B., Dean M., Levy G. Serum protein binding of drugs during and after pregnancy in rats. Pharmacol Exp Ther 1980, 212:264-268.
69. Gedeon C., Koren G. Designing pregnancy centered medications: drugs which do not cross the human placenta. Placenta 2005, 27:861-868.
70. Kudo N., Sakai A., Mitsumoto A., Hibino Y., Tsuda T., Kawashima Y. Tissue distribution and hepatic subcellular distribution of perfluorooctanoic acid at low doses are different from those at high doses. Biol Pharmacol Bull 2007, 30:1535-1540.
71. Fenton S.E., Reiner J.L., Nakayama S.F., Delinsky A.D., Stanko J.P., Hines E.P., et al. Analysis of pfoa in dosed cd-1 mice. Part 2: disposition of pfoa in tissues and fluids from pregnant and lactating mice and their pups. Reprod Toxicol 2009, 27:365-372.
72. DePierre JW. Personal communication; 2009.
73. Schneider H. Placental transport function. Reprod Fertil Dev 1991, 3:345-353.
74. Rosso P. Changes in the transfer of nutrients across the placenta during normal gestation in the rat. Am J Obstet Gyncol 1975, 122:761-766.
75. Clewell R.A., Kremer J.J., Williams C.C., Campbell J.L., Andersen M.E., Borghoff S.J. Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a pbpk model. Toxicol Sci 2008, 103:241-259.
76. Aperia A., Elinder G. Distal tubular sodium reabsorption in the developing rat kidney. Am J Physiol Renal Physiol 1981, 240:487.
77. Bengele H.H., Solomon S. Development of renal response to blood volume expansion in the rat. Am J Physiol 1974, 227:364-368.
78. Buist S.C.N., Cherrington N.J., Choudhuri S., Hartley D.P., Klaasen C.D. Gender-specific and developmental influences on the expression of rat organic anion transporters. Pharmacol Exp Ther 2002, 301:145-151.
79. Buist S.C.N., Klaasen C.D. Rat and mouse differences in gender-predominant expression of organic anion transporter (oat1-3;slc22a6-8) mrna levels. Drug Metab Dispos 2004, 32:620-625.
80. CharlesRiverLaboratories; 2009.
81. Clewell R.A., Merrill E.A., Yu K.O., Mahle D., Sterner T.R., Mattie D.R., et al. Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: a physiologically based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat. Toxicol Sci 2003, 73:235-255.
82. Yoon M., Nong A., Clewell H.J., Taylor M.D., Dorman D.C., Andersen M.E. Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposure with a pbpk model. Toxicol Sci 2009, 112:44-58.
83. Brown R.P., Delp M.D., Lindstedt M.D., Rhomberg L.R., Beliles R.P. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 1997, 13:407-484.
84. Hanwell A., Linzell J.L. The time course of cardiovascular changes in lactation in the rat. J Physiol 1973, 233:93-109.
85. Naismith D.J., Richardson D.P., Pritchard A.E. The utilization of protein and energy during lactation in the rat, with particular regard to the use of fat accumulated in pregnancy. Br J Nutr 1982, 48:433-441.
86. Rosso P., Keyou G., Bassi J.A., Slusser W.M. Effect of malnutrition during pregnancy on the development of the mammary gland of rats. J Nutr 1981, 111:1937-1941.
87. Clewell R.A., Merrill E.A., Yu K.O., Mahle D., Sterner T.R., Fisher J.W., et al. Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling. Toxicol Sci 2003, 74:416-436.
88. O'Flaherty E.J., Scott W., Schreiner C., Beliles R.P. A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. Toxicol Appl Pharmacol 1992, 112:245-256.
89. Dowell R.T., Kauer C.D. Maternal hemodynamics and uteroplacental blood flow throughout gestation in conscious rats. Meth Find Exp Clin Pharmacol 1997, 19:613-625.
90. Ehresman D.J., Froehlich J.W., Olsen G.W., Chang S.-C., Butenhoff J.L. Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (pfos), perfluorooctanoate (pfoa), and other fluorochemicals. Environ Res 2007, 103:176-184.
91. Davies B., Morris T. Physiological parameters in laboratory animals and humans. Pharm Res 1993, 10:1093-1095.
92. Conrad K.P. Renal hemodynamics during pregnancy in chronically catheterized, conscious rats. Kidney Int 1984, 26:24-29.
93. Buelke-Sam J., Holson J.F., Nelson C.J. Blood flow during pregnancy in the rat: Ii. Dynamics of and litter variability in uterine flow. Teratology 1982, 26:279-288.
94. Goedbloed J.F. Embryonic and postnatal growth of rat and mouse. Acta Anat 1976, 95:8-33.
95. Sikov M.R., Thomas J.M. Prenatal growth of the rat. Growth 1970, 34:1-14.
96. Schneidereit M. Study of fetal organ growth in wistar rats from day 17 to 21. Lab Anim 1985, 19:240-244.
97. Wykoff M.H. Weight changes of the developing rat conceptus. Am J Vet Res 1971, 32:1633-1635.
98. Itskovitz J., LaGamma E.F., Rudolph A.M. Effects of cord compression on fetal blood flow distribution and o2 delivery. Am J Physiol Heart Circ Physiol 1987, 252:H100-H109.
99. Carter A.M., Gu W. Cerebral blood flow in the fetal guinea pig. J Dev Physiol 1988, 10:123-129.
100. Yoon M., Nong A., Clewell H.J., Taylor M.D., Dorman D.C., Andersen M.E. Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model. Toxicol Sci 2009, 112:23-43.
101. Shirley B. The food intake of rats during pregnancy and lactation. Lab Anim Sci 1984, 34:169-172.
102. Fisher J.W., Whittaker T.A., Taylor D.H., Clewell H.J., Andersen M.E. Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol Appl Pharmacol 1990, 102:497-513.
103. Yoon M., Barton H.A. Predicting materal rat and pup exposures: how different are they?. Toxicol Sci 2008, 102:15-32.
104. Mirfazaelian A., Kim K., Lee S., Kim H.J., Bruckner J.V., Fisher J.W. Organ growth functions in maturing male sprague-dawley rats. J Toxicol Environ Health Part A 2007, 70:429-438.
105. Garcia J.F. Changes in blood, plasma, and red cell volume in the male rat as a function of age. Am J Physiol 1957, 190:19-24.
106. Rodriguez C.E., Mahle D., Gearhart J., Mattie D.R., Lipscomb J.C., Cook R.S., et al. Predicting age-appropriate pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically based pharmacokinetic modeling. Toxicol Sci 2007, 98:43-56.
107. Stulcova B. Postnatal development of cardiac output distribution measured by radioactive microspheres in rats. Biol Neonate 1977, 32:119-124.
108. Gibson SJ, Johnson JD. Extent and route of excretion of total carbon-14 in pregnant rats after a single oral dose of ammonium 14c-perfluorooctanoate. Riker Laboratories, Inc; 1983.
109. Atherton J.C. Glomerular filtration rate and salt and water reabsorption during pregnancy in the conscious rat. J Physiol 1982, 334:493-504.
110. Nakagawa H., Hirata T., Terada T., Jutabha P., Miura D., Harada K., et al. Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid. Basic Clin Pharmacol Toxicol 2007, 103:1-8.
111. Cha S.H., Sekine T., Kusuhara H., Yu E., Kim J.Y., Kim D.K., et al. Molecular cloning and characterization of the multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 2000, 275:4507-4512.
112. Leazer T.M., Klaassen C.D. The presence of xenobiotic transporters in rat placenta. Drug Metab Dispos 2002, 31:153-167.
113. Lai P.C.W., Forrester P.I., Hancock R.L., Hay D.M., Lorscheider F.L. Rat alpha-fetoprotein: isolation, radioimmunoassay and fetal-maternal distribution during pregnancy. J Reprod Fertil 1976, 48:1-8.
114. Horster M., Lewy J.E. Filtration fraction and extraction of pah during neonatal period in the rat. Am J Physiol 1970, 219:1061-1065.
115. Liao W.S.L., Conn A.R., Taylor J.M. Changes in rat a1-fetoprotein and albumin mrna levels during fetal and neonatal development. J Biol Chem 1980, 255:10036-10039.
116. Rodriguez C.E., Setzer R.W., Barton H.A. Pharmacokinetic modeling of perfluorooctanoic acid during gestation and lactation in the mouse. Reprod Toxicol 2009, 27:373-386.
117. Lou I., Wambaugh J.F., Lau C., Hanson R.G., Lindstrom A.B., Strynar M.J., et al. Modeling single and repeated dose pharmacokinetics of pfoa in mice. Toxicol Sci 2009, 107:331-341.
118. 2 delivery. Am J Physiol Heart Circ Physiol 1987, 252:H100-H109.
119. Carter A.M., Wu G. Cerebral blood flow in the fetal guinea pig. J Develop Physiol 1988, 10:123-129.
120. Yoon M., Barton H.A. Predicting maternal rat and pup exposures: how different are they?. Toxicol Sci 2008, 102:15-32.