Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: A physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat

Toxicological Sciences

Volumn 73, Issue 2, 2003, Pages 235-255

  Clewell, Rebecca A ^a   Merrill, Elaine A ^b   Yu, Kyung O ^c   Mahle, Deirdre A ^d   Sterner, Teresa R ^b   Mattie, David R ^c   Robinson, Peter J ^d   Fisher, Jeffrey W ^c,e   Gearhart, Jeffrey M ^d  

^a WRIGHT PATTERSON AIR FORCE BASE   (United States)

^b Operational Technologies Inc   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

^d ALION SCIENCE AND TECHNOLOGY   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

Author keywords

Fetal dose; Inhibition; Iodide; PBPK model; Perchlorate; Pregnancy; Thyroid

Indexed keywords

IODINE 131; PERCHLORATE; THYROID HORMONE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PLACENTA BARRIER; COMPARTMENT MODEL; COMPETITIVE INHIBITION; COMPUTER PROGRAM; COMPUTER SIMULATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS; HUMAN; INHIBITION KINETICS; IODINE DEFICIENCY; KIDNEY PARENCHYMA; LETHAL DOSE; LIVER; MALE; MAMMARY GLAND; MATERNAL PLASMA; MICHAELIS MENTEN KINETICS; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA; PLACENTAL TRANSFER; PRENATAL DRUG EXPOSURE; RAT; SKIN; STOMACH; THIRD TRIMESTER PREGNANCY; THYROID GLAND; THYROID HORMONE SYNTHESIS; TOXICITY TESTING; TOXICOKINETICS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG INTERACTIONS; FEMALE; FETUS; IODIDES; MALE; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; PERCHLORIC ACID; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SODIUM COMPOUNDS; THYROID GLAND; WATER SUPPLY;

ANIMALIA;

EID: 0038172567     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg081     Document Type: Article

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