Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to Di-n-butylphthalate: Evaluation with a PBPK model

Toxicological Sciences

Volumn 103, Issue 2, 2008, Pages 241-259

  Clewell, Rebecca A ^a,b   Kremer, John J ^b,c   Williams, Carla C ^b   Campbell, Jerry L ^b   Andersen, Melvin E ^b   Borghoff, Susan J ^b,d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c BOSTON SCIENTIFIC CORPORATION   (United States)

^d INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

DBP; Gestation; Glucuronide; Kinetics; PBPK model; Phthalate; Rat

Indexed keywords

GLUCURONOSYLTRANSFERASE; PHTHALIC ACID BUTYL ESTER; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID ESTER;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; BREEDING; CONTROLLED STUDY; DOSE RESPONSE; ENTEROHEPATIC CIRCULATION; FECES LEVEL; FEMALE; FETUS; GLUCURONIDATION; HALF LIFE TIME; HYDROLYSIS; IN VIVO STUDY; LIVER CIRCULATION; MALE; MEAN RESIDENCE TIME; NONHUMAN; PLACENTAL TRANSFER; PREGNANCY; RAT; SENSITIVITY ANALYSIS; TESTIS; TOXICOKINETICS; URINARY EXCRETION; URINE LEVEL;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; DIBUTYL PHTHALATE; FEMALE; FETUS; GLUCURONIDES; MALE; MATERNAL EXPOSURE; MODELS, BIOLOGICAL; PHTHALIC ACIDS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS;

EID: 43349085866     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn054     Document Type: Article

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