Lactational transfer of manganese in rats: Predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model

Toxicological Sciences

Volumn 112, Issue 1, 2009, Pages 23-43

  Yoon, Miyoung ^a   Nong, Andy ^a   Clewell, Harvey J ^a   Taylor, Michael D ^b   Dorman, David C ^a,c   Andersen, Melvin E ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b AFTON CHEMICAL CORPORATION   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Enhanced biliary excretion; Homeostasis during lactation; Inhalation exposure; Manganese; PBPK; Postnatal period

Indexed keywords

MANGANESE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CENTRAL NERVOUS SYSTEM; CLEARANCE; DIETARY INTAKE; EXPOSURE; GASTROINTESTINAL ABSORPTION; INTOXICATION; NERVE STIMULATION; NONHUMAN; PUP (RODENT); RAT; RISK ASSESSMENT; TOXIC INHALATION; TOXICOKINETICS;

ANIMALS; ANIMALS, NEWBORN; FEMALE; INHALATION EXPOSURE; LACTATION; MANGANESE; MILK; MODELS, BIOLOGICAL; PREGNANCY; RATS; TISSUE DISTRIBUTION;

RATTUS;

EID: 71049167857     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp197     Document Type: Article

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