Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling

Toxicological Sciences

Volumn 74, Issue 2, 2003, Pages 416-436

  Clewell, Rebecca A ^a,e   Merrill, Elaine A ^a   Yu, Kyung O ^b   Mahle, Deirdre A ^c   Sterner, Teresa R ^d   Fisher, Jeffrey W ^b,f   Gearhart, Jeffery M ^d  

^a WRIGHT PATTERSON AIR FORCE BASE   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

^c ALION SCIENCE AND TECHNOLOGY   (United States)

^d Operational Technologies Inc   (United States)

^e CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^f UNIVERSITY OF GEORGIA   (United States)

Author keywords

Inhibition; Iodide; Lactation; Milk; PBPK model; Perchlorate

Indexed keywords

IODIDE; PERCHLORATE; RADIOACTIVE IODINE; SODIUM IODIDE SYMPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CLEARANCE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSIMETRY; FEMALE; FETUS; ION TRANSPORT; LACTATION; MAMMARY GLAND; MICHAELIS MENTEN KINETICS; MILK; NONHUMAN; PLASMA; PREDICTION; RAT; REVIEW; SIMULATION; SKIN; STOMACH; THYROID GLAND; TOXICOKINETICS;

ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; BINDING, COMPETITIVE; FEMALE; IODINE RADIOISOTOPES; LACTATION; MILK; MODELS, BIOLOGICAL; PERCHLORIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SODIUM COMPOUNDS; SYMPORTERS; WATER POLLUTANTS, CHEMICAL;

ANIMALIA;

EID: 0043092167     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg147     Document Type: Review

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