메뉴 건너뛰기




Volumn 358, Issue 2, 2012, Pages 223-231

The role of progesterone signaling in the pathogenesis of uterine leiomyoma

Author keywords

Leiomyoma; Progesterone; Progesterone receptor; Uterine leiomyoma

Indexed keywords

2 METHOXYESTRADIOL; AROMATASE; ASOPRISNIL; CATECHOL METHYLTRANSFERASE; CYCLINE; ESTRADIOL; ESTROGEN; GONADORELIN AGONIST; GROWTH FACTOR; J 687; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MICRORNA 20A; MICRORNA 21; MICRORNA 26A; MIFEPRISTONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MODULATOR; PROTEIN TYROSINE KINASE; TELAPRISTONE ACETATE; TRANSCRIPTION FACTOR FKHR; ULIPRISTAL; UNCLASSIFIED DRUG;

EID: 84861528492     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.05.044     Document Type: Review
Times cited : (145)

References (146)
  • 1
    • 0023742639 scopus 로고
    • Patterns of growth of uterine leiomyomas during pregnancy. A prospective longitudinal study
    • Aharoni A., Reiter A., Golan D., Paltiely Y., Sharf M. Patterns of growth of uterine leiomyomas during pregnancy. A prospective longitudinal study. Br. J. Obstet. Gynecol. 1988, 95:510-513.
    • (1988) Br. J. Obstet. Gynecol. , vol.95 , pp. 510-513
    • Aharoni, A.1    Reiter, A.2    Golan, D.3    Paltiely, Y.4    Sharf, M.5
  • 2
    • 77951578183 scopus 로고    scopus 로고
    • Magnetic resonance-guided focused ultrasound surgery
    • Al Hilli M.M., Stewart E.A. Magnetic resonance-guided focused ultrasound surgery. Semin. Reprod. Med. 2010, 28:242-249.
    • (2010) Semin. Reprod. Med. , vol.28 , pp. 242-249
    • Al Hilli, M.M.1    Stewart, E.A.2
  • 3
    • 0037250143 scopus 로고    scopus 로고
    • Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma
    • Arici A., Sozen I. Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma. Am. J. Obstet. Gynecol. 2003, 188:76-83.
    • (2003) Am. J. Obstet. Gynecol. , vol.188 , pp. 76-83
    • Arici, A.1    Sozen, I.2
  • 4
    • 42049121934 scopus 로고    scopus 로고
    • Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance
    • Arpino G., Wiechmann L., Osborne C.K., Schiff R. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr. Rev. 2008, 29:217-233.
    • (2008) Endocr. Rev. , vol.29 , pp. 217-233
    • Arpino, G.1    Wiechmann, L.2    Osborne, C.K.3    Schiff, R.4
  • 5
    • 66549088116 scopus 로고    scopus 로고
    • Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial
    • Bagaria M., Suneja A., Vaid N.B., Guleria K., Mishra K. Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial. Aust. N Z J Obstet. Gynecol. 2009, 49:77-83.
    • (2009) Aust. N Z J Obstet. Gynecol. , vol.49 , pp. 77-83
    • Bagaria, M.1    Suneja, A.2    Vaid, N.B.3    Guleria, K.4    Mishra, K.5
  • 8
    • 0035130117 scopus 로고    scopus 로고
    • 17-beta estradiol elicits an autocrine leiomyoma cell proliferation: evidence for a stimulation of protein kinase-dependent pathway
    • Barbarisi A., Petillo O., Di Lieto A., Melone M.A., Margarucci S., Cannas M., Peluso G. 17-beta estradiol elicits an autocrine leiomyoma cell proliferation: evidence for a stimulation of protein kinase-dependent pathway. J. Cell. Physiol. 2001, 186:414-424.
    • (2001) J. Cell. Physiol. , vol.186 , pp. 414-424
    • Barbarisi, A.1    Petillo, O.2    Di Lieto, A.3    Melone, M.A.4    Margarucci, S.5    Cannas, M.6    Peluso, G.7
  • 10
    • 0025077575 scopus 로고
    • Expression of the insulin-like and platelet-derived growth factor genes in human uterine tissues
    • Boehm K.D., Daimon M., Gorodeski I.G., Sheean L.A., Utian W.H., Ilan J. Expression of the insulin-like and platelet-derived growth factor genes in human uterine tissues. Mol. Reprod. Dev. 1990, 27:93-101.
    • (1990) Mol. Reprod. Dev. , vol.27 , pp. 93-101
    • Boehm, K.D.1    Daimon, M.2    Gorodeski, I.G.3    Sheean, L.A.4    Utian, W.H.5    Ilan, J.6
  • 11
    • 0034852802 scopus 로고    scopus 로고
    • Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases
    • Boonyaratanakornkit V., Scott M.P., Ribon V., Sherman L., Anderson S.M., Maller J.L., Miller W.T., Edwards D.P. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol. Cell. 2001, 8:269-280.
    • (2001) Mol. Cell. , vol.8 , pp. 269-280
    • Boonyaratanakornkit, V.1    Scott, M.P.2    Ribon, V.3    Sherman, L.4    Anderson, S.M.5    Maller, J.L.6    Miller, W.T.7    Edwards, D.P.8
  • 12
    • 0033755948 scopus 로고    scopus 로고
    • Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat
    • Burroughs K.D., Fuchs-Young R., Davis B., Walker C.L. Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat. Biol. Reprod. 2000, 63:1322-1330.
    • (2000) Biol. Reprod. , vol.63 , pp. 1322-1330
    • Burroughs, K.D.1    Fuchs-Young, R.2    Davis, B.3    Walker, C.L.4
  • 15
    • 0027278471 scopus 로고
    • An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial
    • Carr B.R., Marshburn P.B., Weatherall P.T., Bradshaw K.D., Breslau N.A., Byrd W., Roark M., Steinkampf M.P. An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial. J. Clin. Endocrinol. Metab. 1993, 76:1217-1223.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1217-1223
    • Carr, B.R.1    Marshburn, P.B.2    Weatherall, P.T.3    Bradshaw, K.D.4    Breslau, N.A.5    Byrd, W.6    Roark, M.7    Steinkampf, M.P.8
  • 16
    • 0036842424 scopus 로고    scopus 로고
    • Coordinated regulation of HOX gene expression in myometrium and uterine leiomyoma
    • Cermik D., Arici A., Taylor H.S. Coordinated regulation of HOX gene expression in myometrium and uterine leiomyoma. Fertil Steril 2002, 78:979-984.
    • (2002) Fertil Steril , vol.78 , pp. 979-984
    • Cermik, D.1    Arici, A.2    Taylor, H.S.3
  • 17
    • 0033323804 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-beta1 expression by granulocyte macrophage-colony-stimulating factor in leiomyoma and myometrial smooth muscle cells
    • Chegini N., Tang X.M., Ma C. Regulation of transforming growth factor-beta1 expression by granulocyte macrophage-colony-stimulating factor in leiomyoma and myometrial smooth muscle cells. J. Clin. Endocrinol. Metab. 1999, 84:4138-4143.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 4138-4143
    • Chegini, N.1    Tang, X.M.2    Ma, C.3
  • 18
    • 77951590255 scopus 로고    scopus 로고
    • Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder
    • Chegini, N., 2010. Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder. Semin. Reprod. Med. 28, 180-203.
    • (2010) Semin. Reprod. Med. , vol.28 , pp. 180-203
    • Chegini, N.1
  • 19
    • 33646067165 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells
    • Chen W., Ohara N., Wang J., Xu Q., Liu J., Morikawa A., Sasaki H., Yoshida S., Demanno D.A., Chwalisz K., Maruo T. A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. J. Clin. Endocrinol. Metab. 2006, 91:1296-1304.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1296-1304
    • Chen, W.1    Ohara, N.2    Wang, J.3    Xu, Q.4    Liu, J.5    Morikawa, A.6    Sasaki, H.7    Yoshida, S.8    Demanno, D.A.9    Chwalisz, K.10    Maruo, T.11
  • 21
    • 34249712002 scopus 로고    scopus 로고
    • A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata
    • Chwalisz, K., Larsen, L., Mattia-Goldberg, C., Edmonds, A., Elger, W., Winkel, C.A., 2007. A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata. Fertil Steril.
    • (2007) Fertil Steril.
    • Chwalisz, K.1    Larsen, L.2    Mattia-Goldberg, C.3    Edmonds, A.4    Elger, W.5    Winkel, C.A.6
  • 23
    • 34648843470 scopus 로고    scopus 로고
    • Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats
    • Cook J.D., Davis B.J., Goewey J.A., Berry T.D., Walker C.L. Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats. Reprod. Sci. 2007, 14:121-136.
    • (2007) Reprod. Sci. , vol.14 , pp. 121-136
    • Cook, J.D.1    Davis, B.J.2    Goewey, J.A.3    Berry, T.D.4    Walker, C.L.5
  • 24
    • 0025061721 scopus 로고
    • The frequency of uterine leiomyomas
    • Cramer S.F., Patel A. The frequency of uterine leiomyomas. Am. J. Clin. Pathol. 1990, 94:435-438.
    • (1990) Am. J. Clin. Pathol. , vol.94 , pp. 435-438
    • Cramer, S.F.1    Patel, A.2
  • 26
    • 47649110244 scopus 로고    scopus 로고
    • A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells
    • Di X., Yu L., Moore A.B., Castro L., Zheng X., Hermon T., Dixon D. A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells. Hum. Reprod. 2008, 23:1873-1883.
    • (2008) Hum. Reprod. , vol.23 , pp. 1873-1883
    • Di, X.1    Yu, L.2    Moore, A.B.3    Castro, L.4    Zheng, X.5    Hermon, T.6    Dixon, D.7
  • 27
    • 0029845934 scopus 로고    scopus 로고
    • Suppression of transforming growth factor-beta (TGF beta) and TGF beta receptor messenger ribonucleic acid and protein expression in leiomyomata in women receiving gonadotropin-releasing hormone agonist therapy
    • Dou Q., Zhao Y., Tarnuzzer R.W., Rong H., Williams R.S., Schultz G.S., Chegini N. Suppression of transforming growth factor-beta (TGF beta) and TGF beta receptor messenger ribonucleic acid and protein expression in leiomyomata in women receiving gonadotropin-releasing hormone agonist therapy. J. Clin. Endocrinol. Metab. 1996, 81:3222-3230.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3222-3230
    • Dou, Q.1    Zhao, Y.2    Tarnuzzer, R.W.3    Rong, H.4    Williams, R.S.5    Schultz, G.S.6    Chegini, N.7
  • 32
    • 77950516978 scopus 로고    scopus 로고
    • Improved quality of life is partly explained by fewer symptoms after treatment of fibroids with mifepristone
    • Feng C., Meldrum S., Fiscella K. Improved quality of life is partly explained by fewer symptoms after treatment of fibroids with mifepristone. Int. J. Gynecol. Obstet. 2010, 109:121-124.
    • (2010) Int. J. Gynecol. Obstet. , vol.109 , pp. 121-124
    • Feng, C.1    Meldrum, S.2    Fiscella, K.3
  • 33
    • 33845402183 scopus 로고    scopus 로고
    • Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial
    • Fiscella K., Eisinger S.H., Meldrum S., Feng C., Fisher S.G., Guzick D.S. Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial. Obstet. Gynecol. 2006, 108:1381-1387.
    • (2006) Obstet. Gynecol. , vol.108 , pp. 1381-1387
    • Fiscella, K.1    Eisinger, S.H.2    Meldrum, S.3    Feng, C.4    Fisher, S.G.5    Guzick, D.S.6
  • 34
    • 33748779351 scopus 로고    scopus 로고
    • Health care resource use for uterine fibroid tumors in the United States
    • Flynn M., Jamison M., Datta S., Myers E. Health care resource use for uterine fibroid tumors in the United States. Am. J. Obstet. Gynecol. 2006, 195:955-964.
    • (2006) Am. J. Obstet. Gynecol. , vol.195 , pp. 955-964
    • Flynn, M.1    Jamison, M.2    Datta, S.3    Myers, E.4
  • 35
    • 0032745104 scopus 로고    scopus 로고
    • Effect of the levonorgestrel-releasing intrauterine system on uterine myomas in a renal transplant patient
    • Fong Y.F., Singh K. Effect of the levonorgestrel-releasing intrauterine system on uterine myomas in a renal transplant patient. Contraception 1999, 60:51-53.
    • (1999) Contraception , vol.60 , pp. 51-53
    • Fong, Y.F.1    Singh, K.2
  • 36
    • 77951617393 scopus 로고    scopus 로고
    • Uterine artery embolization for fibroids: a review of current outcomes
    • Freed M.M., Spies J.B. Uterine artery embolization for fibroids: a review of current outcomes. Semin. Reprod. Med. 2010, 28:235-241.
    • (2010) Semin. Reprod. Med. , vol.28 , pp. 235-241
    • Freed, M.M.1    Spies, J.B.2
  • 37
    • 0027273447 scopus 로고
    • A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin "add-back" regimens for women with leiomyomata uteri
    • Friedman A.J., Daly M., Juneau-Norcross M., Rein M.S., Fine C., Gleason R., Leboff M. A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin "add-back" regimens for women with leiomyomata uteri. J. Clin. Endocrinol. Metab. 1993, 76:1439-1445.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1439-1445
    • Friedman, A.J.1    Daly, M.2    Juneau-Norcross, M.3    Rein, M.S.4    Fine, C.5    Gleason, R.6    Leboff, M.7
  • 38
    • 0028064250 scopus 로고
    • Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin 'add-back' for 2 years
    • Friedman A.J., Daly M., Juneau-Norcross M., Gleason R., Rein M.S., LeBoff M. Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin 'add-back' for 2 years. Hum. Reprod. 1994, 9:1618-1625.
    • (1994) Hum. Reprod. , vol.9 , pp. 1618-1625
    • Friedman, A.J.1    Daly, M.2    Juneau-Norcross, M.3    Gleason, R.4    Rein, M.S.5    LeBoff, M.6
  • 39
    • 0035180145 scopus 로고    scopus 로고
    • Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cells
    • Gao Z., Matsuo H., Wang Y., Nakago S., Maruo T. Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cells. J. Clin. Endocrinol. Metab. 2001, 86:5593-5599.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5593-5599
    • Gao, Z.1    Matsuo, H.2    Wang, Y.3    Nakago, S.4    Maruo, T.5
  • 40
    • 0027515736 scopus 로고
    • Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata
    • Giudice L.C., Irwin J.C., Dsupin B.A., Pannier E.M., Jin I.H., Vu T.H., Hoffman A.R. Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata. Hum. Reprod. 1993, 8:1796-1806.
    • (1993) Hum. Reprod. , vol.8 , pp. 1796-1806
    • Giudice, L.C.1    Irwin, J.C.2    Dsupin, B.A.3    Pannier, E.M.4    Jin, I.H.5    Vu, T.H.6    Hoffman, A.R.7
  • 41
    • 0038638994 scopus 로고    scopus 로고
    • Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas
    • Grigorieva V., Chen-Mok M., Tarasova M., Mikhailov A. Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas. Fertil Steril 2003, 79:1194-1198.
    • (2003) Fertil Steril , vol.79 , pp. 1194-1198
    • Grigorieva, V.1    Chen-Mok, M.2    Tarasova, M.3    Mikhailov, A.4
  • 43
    • 0028212465 scopus 로고
    • Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction
    • Harrison-Woolrych M.L., Charnock-Jones D.S., Smith S.K. Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. J. Clin. Endocrinol. Metab. 1994, 78:1179-1184.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 1179-1184
    • Harrison-Woolrych, M.L.1    Charnock-Jones, D.S.2    Smith, S.K.3
  • 44
    • 35348950974 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of a dominant-negative estrogen receptor gene in uterine leiomyoma cells abrogates estrogen- and progesterone-regulated gene expression
    • Hassan M.H., Salama S.A., Arafa H.M., Hamada F.M., Al-Hendy A. Adenovirus-mediated delivery of a dominant-negative estrogen receptor gene in uterine leiomyoma cells abrogates estrogen- and progesterone-regulated gene expression. J. Clin. Endocrinol. Metab. 2007, 92:3949-3957.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 3949-3957
    • Hassan, M.H.1    Salama, S.A.2    Arafa, H.M.3    Hamada, F.M.4    Al-Hendy, A.5
  • 45
    • 72749106400 scopus 로고    scopus 로고
    • Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model
    • Hassan M.H., Salama S.A., Zhang D., Arafa H.M., Hamada F.M., Fouad H., Walker C.C., Al-Hendy A. Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model. Fertil. Steril. 2010, 93:239-250.
    • (2010) Fertil. Steril. , vol.93 , pp. 239-250
    • Hassan, M.H.1    Salama, S.A.2    Zhang, D.3    Arafa, H.M.4    Hamada, F.M.5    Fouad, H.6    Walker, C.C.7    Al-Hendy, A.8
  • 46
    • 55849094716 scopus 로고    scopus 로고
    • Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium
    • Hermon T.L., Moore A.B., Yu L., Kissling G.E., Castora F.J., Dixon D. Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium. Virchows Arch. 2008, 453:557-569.
    • (2008) Virchows Arch. , vol.453 , pp. 557-569
    • Hermon, T.L.1    Moore, A.B.2    Yu, L.3    Kissling, G.E.4    Castora, F.J.5    Dixon, D.6
  • 47
    • 57849113658 scopus 로고    scopus 로고
    • Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients
    • Hilario S.G., Bozzini N., Borsari R., Baracat E.C. Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients. Fertil. Steril. 2009, 91:240-243.
    • (2009) Fertil. Steril. , vol.91 , pp. 240-243
    • Hilario, S.G.1    Bozzini, N.2    Borsari, R.3    Baracat, E.C.4
  • 50
    • 35548972976 scopus 로고    scopus 로고
    • Progesterone receptor modulators and the endometrium: changes and consequences
    • Horne F.M., Blithe D.L. Progesterone receptor modulators and the endometrium: changes and consequences. Hum. Reprod. Update 2007, 13:567-580.
    • (2007) Hum. Reprod. Update , vol.13 , pp. 567-580
    • Horne, F.M.1    Blithe, D.L.2
  • 51
    • 0029036505 scopus 로고
    • Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines
    • Howe S.R., Gottardis M.M., Everitt J.I., Goldsworthy T.L., Wolf D.C., Walker C. Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am. J. Pathol. 1995, 146:1568-1579.
    • (1995) Am. J. Pathol. , vol.146 , pp. 1568-1579
    • Howe, S.R.1    Gottardis, M.M.2    Everitt, J.I.3    Goldsworthy, T.L.4    Wolf, D.C.5    Walker, C.6
  • 52
    • 38949146061 scopus 로고    scopus 로고
    • Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata
    • Hwu Y.M., Li S.H., Lee R.K., Tsai Y.H., Yeh T.S., Lin S.Y. Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata. Fertil. Steril. 2008, 89:468-471.
    • (2008) Fertil. Steril. , vol.89 , pp. 468-471
    • Hwu, Y.M.1    Li, S.H.2    Lee, R.K.3    Tsai, Y.H.4    Yeh, T.S.5    Lin, S.Y.6
  • 55
    • 77954472057 scopus 로고    scopus 로고
    • Progesterone is essential for maintenance and growth of uterine leiomyoma
    • Ishikawa H., Ishi K., Serna V.A., Kakazu R., Bulun S.E., Kurita T. Progesterone is essential for maintenance and growth of uterine leiomyoma. Endocrinology 2010, 151:2433-2442.
    • (2010) Endocrinology , vol.151 , pp. 2433-2442
    • Ishikawa, H.1    Ishi, K.2    Serna, V.A.3    Kakazu, R.4    Bulun, S.E.5    Kurita, T.6
  • 56
    • 0032409172 scopus 로고    scopus 로고
    • The effect of a levonorgestrel-releasing intrauterine system on uterine artery blood flow, hormone concentrations and ovarian cyst formation in fertile women
    • Jarvela I., Tekay A., Jouppila P. The effect of a levonorgestrel-releasing intrauterine system on uterine artery blood flow, hormone concentrations and ovarian cyst formation in fertile women. Hum. Reprod. 1998, 13:3379-3383.
    • (1998) Hum. Reprod. , vol.13 , pp. 3379-3383
    • Jarvela, I.1    Tekay, A.2    Jouppila, P.3
  • 57
    • 77952109487 scopus 로고    scopus 로고
    • Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology
    • Karra L., Shushan A., Ben-Meir A., Rojansky N., Klein B.Y., Shveiky D., Levitzki R., Ben-Bassat H. Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology. Fertil. Steril. 2010, 93:2646-2651.
    • (2010) Fertil. Steril. , vol.93 , pp. 2646-2651
    • Karra, L.1    Shushan, A.2    Ben-Meir, A.3    Rojansky, N.4    Klein, B.Y.5    Shveiky, D.6    Levitzki, R.7    Ben-Bassat, H.8
  • 59
    • 0025989383 scopus 로고
    • Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy
    • Kawaguchi K., Fujii S., Konishi I., Iwai T., Nanbu Y., Nonogaki H., Ishikawa Y., Mori T. Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy. Virchows Arch. A Pathol. Anat. Histopathol. 1991, 419:309-315.
    • (1991) Virchows Arch. A Pathol. Anat. Histopathol. , vol.419 , pp. 309-315
    • Kawaguchi, K.1    Fujii, S.2    Konishi, I.3    Iwai, T.4    Nanbu, Y.5    Nonogaki, H.6    Ishikawa, Y.7    Mori, T.8
  • 60
    • 38449090730 scopus 로고    scopus 로고
    • Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle
    • Kayisli U.A., Berkkanoglu M., Kizilay G., Senturk L., Arici A. Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle. Reprod. Sci. 2007, 14:678-686.
    • (2007) Reprod. Sci. , vol.14 , pp. 678-686
    • Kayisli, U.A.1    Berkkanoglu, M.2    Kizilay, G.3    Senturk, L.4    Arici, A.5
  • 62
    • 71649101716 scopus 로고    scopus 로고
    • Loss of let-7 binding sites resulting from truncations of the 3' untranslated region of HMGA2 mRNA in uterine leiomyomas
    • Klemke, M., Meyer, A., Hashemi Nezhad, M., Belge, G., Bartnitzke, S., Bullerdiek, J., 2010. Loss of let-7 binding sites resulting from truncations of the 3' untranslated region of HMGA2 mRNA in uterine leiomyomas. Cancer Genet Cytogenet 196, 119-23.
    • (2010) Cancer Genet Cytogenet , vol.196 , pp. 119-23
    • Klemke, M.1    Meyer, A.2    Hashemi Nezhad, M.3    Belge, G.4    Bartnitzke, S.5    Bullerdiek, J.6
  • 63
    • 0028830856 scopus 로고
    • A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
    • Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y., Hino O. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat. Genet. 1995, 9:70-74.
    • (1995) Nat. Genet. , vol.9 , pp. 70-74
    • Kobayashi, T.1    Hirayama, Y.2    Kobayashi, E.3    Kubo, Y.4    Hino, O.5
  • 65
    • 33846437521 scopus 로고    scopus 로고
    • Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri
    • Kovacs K.A., Lengyel F., Vertes Z., Kornyei J.L., Gocze P.M., Sumegi B., Szabo I., Vertes M. Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri. J. Steroid Biochem. Mol. Biol. 2007, 103:196-199.
    • (2007) J. Steroid Biochem. Mol. Biol. , vol.103 , pp. 196-199
    • Kovacs, K.A.1    Lengyel, F.2    Vertes, Z.3    Kornyei, J.L.4    Gocze, P.M.5    Sumegi, B.6    Szabo, I.7    Vertes, M.8
  • 66
    • 77956183175 scopus 로고    scopus 로고
    • Involvement of FKHR (FOXO1) transcription factor in human uterus leiomyoma growth
    • Kovacs K.A., Lengyel F., Wilhelm F., Vertes Z., Sumegi B., Vertes M. Involvement of FKHR (FOXO1) transcription factor in human uterus leiomyoma growth. Fertil. Steril. 2010, 94:1491-1495.
    • (2010) Fertil. Steril. , vol.94 , pp. 1491-1495
    • Kovacs, K.A.1    Lengyel, F.2    Wilhelm, F.3    Vertes, Z.4    Sumegi, B.5    Vertes, M.6
  • 67
    • 0029146454 scopus 로고
    • Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model
    • Kubo Y., Kikuchi Y., Mitani H., Kobayashi E., Kobayashi T., Hino O. Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model. Jpn. J. Cancer Res. 1995, 86:828-832.
    • (1995) Jpn. J. Cancer Res. , vol.86 , pp. 828-832
    • Kubo, Y.1    Kikuchi, Y.2    Mitani, H.3    Kobayashi, E.4    Kobayashi, T.5    Hino, O.6
  • 68
    • 0026759278 scopus 로고
    • Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysis
    • Lamminen S., Rantala I., Helin H., Rorarius M., Tuimala R. Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysis. Gynecol. Obstet. Invest. 1992, 34:111-114.
    • (1992) Gynecol. Obstet. Invest. , vol.34 , pp. 111-114
    • Lamminen, S.1    Rantala, I.2    Helin, H.3    Rorarius, M.4    Tuimala, R.5
  • 69
    • 38749140218 scopus 로고    scopus 로고
    • Integration of progesterone receptor action with rapid signaling events in breast cancer models
    • Lange C.A. Integration of progesterone receptor action with rapid signaling events in breast cancer models. J. Steroid Biochem. Mol. Biol. 2008, 108:203-212.
    • (2008) J. Steroid Biochem. Mol. Biol. , vol.108 , pp. 203-212
    • Lange, C.A.1
  • 70
    • 0035093153 scopus 로고    scopus 로고
    • Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta
    • Lee B.S., Nowak R.A. Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta. J. Clin. Endocrinol. Metab. 2001, 86:913-920.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 913-920
    • Lee, B.S.1    Nowak, R.A.2
  • 71
    • 34247114207 scopus 로고    scopus 로고
    • Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus
    • Lengyel F., Vertes Z., Kovacs K.A., Kornyei J.L., Sumegi B., Vertes M. Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus. Steroids 2007, 72:422-428.
    • (2007) Steroids , vol.72 , pp. 422-428
    • Lengyel, F.1    Vertes, Z.2    Kovacs, K.A.3    Kornyei, J.L.4    Sumegi, B.5    Vertes, M.6
  • 73
    • 32544448224 scopus 로고    scopus 로고
    • Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata
    • Liang M., Wang H., Zhang Y., Lu S., Wang Z. Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata. Cancer Biol. Ther. 2006, 5:28-33.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 28-33
    • Liang, M.1    Wang, H.2    Zhang, Y.3    Lu, S.4    Wang, Z.5
  • 74
    • 55949108160 scopus 로고    scopus 로고
    • The expression and potential regulatory function of microRNAs in the pathogenesis of leiomyoma
    • Luo X., Chegini N. The expression and potential regulatory function of microRNAs in the pathogenesis of leiomyoma. Semin. Reprod. Med. 2008, 26:500-514.
    • (2008) Semin. Reprod. Med. , vol.26 , pp. 500-514
    • Luo, X.1    Chegini, N.2
  • 75
  • 76
    • 77952110601 scopus 로고    scopus 로고
    • The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells
    • Luo, X., Yin, P., Coon, V.J., Cheng, Y.H., Wiehle, R.D., Bulun, S.E., 2010. The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Fertil. Steril. 93, 2668-73.
    • (2010) Fertil. Steril. , vol.93 , pp. 2668-73
    • Luo, X.1    Yin, P.2    Coon, V.J.3    Cheng, Y.H.4    Wiehle, R.D.5    Bulun, S.E.6
  • 77
    • 0014560725 scopus 로고
    • Myomectomy: recurrence after removal of solitary and multiple myomas
    • Malone L.J. Myomectomy: recurrence after removal of solitary and multiple myomas. Obstet. Gynecol. 1969, 34:200-203.
    • (1969) Obstet. Gynecol. , vol.34 , pp. 200-203
    • Malone, L.J.1
  • 79
    • 0029097356 scopus 로고
    • Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium
    • Mangrulkar R.S., Ono M., Ishikawa M., Takashima S., Klagsbrun M., Nowak R.A. Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium. Biol. Reprod. 1995, 53:636-646.
    • (1995) Biol. Reprod. , vol.53 , pp. 636-646
    • Mangrulkar, R.S.1    Ono, M.2    Ishikawa, M.3    Takashima, S.4    Klagsbrun, M.5    Nowak, R.A.6
  • 80
    • 0024395263 scopus 로고
    • Estrogen and progesterone receptors in leiomyomas and normal uterine tissues during reproductive life
    • Marelli G., Codegoni A.M., Bizzi A. Estrogen and progesterone receptors in leiomyomas and normal uterine tissues during reproductive life. Acta Eur. Fertil. 1989, 20:19-22.
    • (1989) Acta Eur. Fertil. , vol.20 , pp. 19-22
    • Marelli, G.1    Codegoni, A.M.2    Bizzi, A.3
  • 81
    • 44349113451 scopus 로고    scopus 로고
    • Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium
    • Marsh E.E., Lin Z., Yin P., Milad M., Chakravarti D., Bulun S.E. Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium. Fertil. Steril. 2008, 89:1771-1776.
    • (2008) Fertil. Steril. , vol.89 , pp. 1771-1776
    • Marsh, E.E.1    Lin, Z.2    Yin, P.3    Milad, M.4    Chakravarti, D.5    Bulun, S.E.6
  • 83
    • 34248678715 scopus 로고    scopus 로고
    • Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas
    • Maruo T., Ohara N., Matsuo H., Xu Q., Chen W., Sitruk-Ware R., Johansson E.D. Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas. Contraception 2007, 75:S99-S103.
    • (2007) Contraception , vol.75
    • Maruo, T.1    Ohara, N.2    Matsuo, H.3    Xu, Q.4    Chen, W.5    Sitruk-Ware, R.6    Johansson, E.D.7
  • 84
    • 0031027688 scopus 로고    scopus 로고
    • Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone
    • Matsuo H., Maruo T., Samoto T. Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone. J. Clin. Endocrinol. Metab. 1997, 82:293-299.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 293-299
    • Matsuo, H.1    Maruo, T.2    Samoto, T.3
  • 86
    • 44249127287 scopus 로고    scopus 로고
    • Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer
    • Morikawa A., Ohara N., Xu Q., Nakabayashi K., DeManno D.A., Chwalisz K., Yoshida S., Maruo T. Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer. Hum. Reprod. 2008, 23:944-951.
    • (2008) Hum. Reprod. , vol.23 , pp. 944-951
    • Morikawa, A.1    Ohara, N.2    Xu, Q.3    Nakabayashi, K.4    DeManno, D.A.5    Chwalisz, K.6    Yoshida, S.7    Maruo, T.8
  • 88
    • 0029049613 scopus 로고
    • Regression of uterine leiomyomata to the antiprogesterone RU486: dose-response effect
    • Murphy A.A., Morales A.J., Kettel L.M., Yen S.S. Regression of uterine leiomyomata to the antiprogesterone RU486: dose-response effect. Fertil Steril 1995, 64:187-190.
    • (1995) Fertil Steril , vol.64 , pp. 187-190
    • Murphy, A.A.1    Morales, A.J.2    Kettel, L.M.3    Yen, S.S.4
  • 90
    • 67649438794 scopus 로고    scopus 로고
    • Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women
    • Nagata C., Nakamura K., Oba S., Hayashi M., Takeda N., Yasuda K. Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women. Br. J. Nutr. 2009, 101:1427-1431.
    • (2009) Br. J. Nutr. , vol.101 , pp. 1427-1431
    • Nagata, C.1    Nakamura, K.2    Oba, S.3    Hayashi, M.4    Takeda, N.5    Yasuda, K.6
  • 92
    • 33749128973 scopus 로고    scopus 로고
    • Pregnancy-related changes in the size of uterine leiomyomas
    • Neiger R., Sonek J.D., Croom C.S., Ventolini G. Pregnancy-related changes in the size of uterine leiomyomas. J. Reprod. Med. 2006, 51:671-674.
    • (2006) J. Reprod. Med. , vol.51 , pp. 671-674
    • Neiger, R.1    Sonek, J.D.2    Croom, C.S.3    Ventolini, G.4
  • 94
    • 70450205241 scopus 로고    scopus 로고
    • Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas
    • Norian J.M., Malik M., Parker C.Y., Joseph D., Leppert P.C., Segars J.H., Catherino W.H. Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. Reprod. Sci. 2009, 16:1153-1164.
    • (2009) Reprod. Sci. , vol.16 , pp. 1153-1164
    • Norian, J.M.1    Malik, M.2    Parker, C.Y.3    Joseph, D.4    Leppert, P.C.5    Segars, J.H.6    Catherino, W.H.7
  • 95
    • 38749121786 scopus 로고    scopus 로고
    • Comparative effects of SPRM asoprisnil (J867) on proliferation, apoptosis, and the expression of growth factors in cultured uterine leiomyoma cells and normal myometrial cells
    • Ohara N., Morikawa A., Chen W., Wang J., DeManno D.A., Chwalisz K., Maruo T. Comparative effects of SPRM asoprisnil (J867) on proliferation, apoptosis, and the expression of growth factors in cultured uterine leiomyoma cells and normal myometrial cells. Reprod. Sci. 2007, 14:20-27.
    • (2007) Reprod. Sci. , vol.14 , pp. 20-27
    • Ohara, N.1    Morikawa, A.2    Chen, W.3    Wang, J.4    DeManno, D.A.5    Chwalisz, K.6    Maruo, T.7
  • 96
    • 77958453918 scopus 로고    scopus 로고
    • Down-regulated progesterone receptor A and B coinciding with successful treatment of endometrial hyperplasia by the levonorgestrel impregnated intrauterine system
    • Orbo A., Arnes M., Pettersen I., Larsen K., Hanssen K., Moe B. Down-regulated progesterone receptor A and B coinciding with successful treatment of endometrial hyperplasia by the levonorgestrel impregnated intrauterine system. Acta Obstet. Gynecol. Scand. 2010, 89:1438-1446.
    • (2010) Acta Obstet. Gynecol. Scand. , vol.89 , pp. 1438-1446
    • Orbo, A.1    Arnes, M.2    Pettersen, I.3    Larsen, K.4    Hanssen, K.5    Moe, B.6
  • 97
    • 41149175606 scopus 로고    scopus 로고
    • Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids
    • Pan Q., Luo X., Chegini N. Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids. J. Cell. Mol. Med. 2008, 12:227-240.
    • (2008) J. Cell. Mol. Med. , vol.12 , pp. 227-240
    • Pan, Q.1    Luo, X.2    Chegini, N.3
  • 98
    • 77950242736 scopus 로고    scopus 로고
    • microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
    • Pan, Q., Luo, X., Chegini, N., 2010. microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells. Mol Hum Reprod 16, 215-27.
    • (2010) Mol Hum Reprod , vol.16 , pp. 215-27
    • Pan, Q.1    Luo, X.2    Chegini, N.3
  • 99
    • 72749091561 scopus 로고    scopus 로고
    • A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status
    • Parsanezhad M.E., Azmoon M., Alborzi S., Rajaeefard A., Zarei A., Kazerooni T., Frank V., Schmidt E.H. A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. Fertil. Steril. 2009, 93:192-198.
    • (2009) Fertil. Steril. , vol.93 , pp. 192-198
    • Parsanezhad, M.E.1    Azmoon, M.2    Alborzi, S.3    Rajaeefard, A.4    Zarei, A.5    Kazerooni, T.6    Frank, V.7    Schmidt, E.H.8
  • 101
    • 67349265981 scopus 로고    scopus 로고
    • Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas
    • Peng L., Wen Y., Han Y., Wei A., Shi G., Mizuguchi M., Lee P., Hernando E., Mittal K., Wei J.J. Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas. Fertil. Steril. 2009, 91:2664-2675.
    • (2009) Fertil. Steril. , vol.91 , pp. 2664-2675
    • Peng, L.1    Wen, Y.2    Han, Y.3    Wei, A.4    Shi, G.5    Mizuguchi, M.6    Lee, P.7    Hernando, E.8    Mittal, K.9    Wei, J.J.10
  • 102
    • 0028199173 scopus 로고
    • The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: a prospective, randomized study
    • Discussion 1627-8
    • Reinsch R.C., Murphy A.A., Morales A.J., Yen S.S. The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: a prospective, randomized study. Am. J. Obstet. Gynecol. 1994, 170:1623-1627. Discussion 1627-8.
    • (1994) Am. J. Obstet. Gynecol. , vol.170 , pp. 1623-1627
    • Reinsch, R.C.1    Murphy, A.A.2    Morales, A.J.3    Yen, S.S.4
  • 104
    • 0027097787 scopus 로고
    • Longitudinal evaluation of uterine myoma growth during pregnancy. A sonographic study
    • Rosati P., Exacoustos C., Mancuso S. Longitudinal evaluation of uterine myoma growth during pregnancy. A sonographic study. J. Ultrasound Med. 1992, 11:511-515.
    • (1992) J. Ultrasound Med. , vol.11 , pp. 511-515
    • Rosati, P.1    Exacoustos, C.2    Mancuso, S.3
  • 108
    • 33846995100 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells
    • Sasaki H., Ohara N., Xu Q., Wang J., DeManno D.A., Chwalisz K., Yoshida S., Maruo T. A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. J. Clin. Endocrinol. Metab. 2007, 92:616-623.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 616-623
    • Sasaki, H.1    Ohara, N.2    Xu, Q.3    Wang, J.4    DeManno, D.A.5    Chwalisz, K.6    Yoshida, S.7    Maruo, T.8
  • 109
    • 78650735049 scopus 로고    scopus 로고
    • A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia
    • Sayed G.H., Zakherah M.S., El-Nashar S.A., Shaaban M.M. A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia. Int. J. Gynaecol. Obstet. 2011, 112:126-130.
    • (2011) Int. J. Gynaecol. Obstet. , vol.112 , pp. 126-130
    • Sayed, G.H.1    Zakherah, M.S.2    El-Nashar, S.A.3    Shaaban, M.M.4
  • 110
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 111
    • 0031763790 scopus 로고    scopus 로고
    • Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma
    • Shimomura Y., Matsuo H., Samoto T., Maruo T. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J. Clin. Endocrinol. Metab. 1998, 83:2192-2198.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2192-2198
    • Shimomura, Y.1    Matsuo, H.2    Samoto, T.3    Maruo, T.4
  • 114
    • 11444265410 scopus 로고    scopus 로고
    • The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial
    • Soysal S., Soysal M.E. The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial. Gynecol. Obstet. Invest. 2005, 59:29-35.
    • (2005) Gynecol. Obstet. Invest. , vol.59 , pp. 29-35
    • Soysal, S.1    Soysal, M.E.2
  • 115
    • 68949176930 scopus 로고    scopus 로고
    • Clinical utility of progesterone receptor modulators and their effect on the endometrium
    • Spitz I.M. Clinical utility of progesterone receptor modulators and their effect on the endometrium. Curr. Opin. Obstet. Gynecol. 2009, 21:318-324.
    • (2009) Curr. Opin. Obstet. Gynecol. , vol.21 , pp. 318-324
    • Spitz, I.M.1
  • 116
    • 0034279458 scopus 로고    scopus 로고
    • Intrauterine therapy with levonorgestrel releasing IUD of women with hypermenorrhea secondary to uterine fibroids
    • Starczewski A., Iwanicki M. Intrauterine therapy with levonorgestrel releasing IUD of women with hypermenorrhea secondary to uterine fibroids. Ginekol. Pol. 2000, 71:1221-1225.
    • (2000) Ginekol. Pol. , vol.71 , pp. 1221-1225
    • Starczewski, A.1    Iwanicki, M.2
  • 117
    • 77949916236 scopus 로고    scopus 로고
    • Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914
    • Stratton P., Levens E.D., Hartog B., Piquion J., Wei Q., Merino M., Nieman L.K. Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914. Fertil Steril 2010, 93:2035-2041.
    • (2010) Fertil Steril , vol.93 , pp. 2035-2041
    • Stratton, P.1    Levens, E.D.2    Hartog, B.3    Piquion, J.4    Wei, Q.5    Merino, M.6    Nieman, L.K.7
  • 118
    • 0029036589 scopus 로고
    • Insulin-like growth factor I promotes leiomyoma cell growth in vitro
    • Discussion 1843-4
    • Strawn E.Y., Novy M.J., Burry K.A., Bethea C.L. Insulin-like growth factor I promotes leiomyoma cell growth in vitro. Am. J. Obstet. Gynecol. 1995, 172:1837-1843. Discussion 1843-4.
    • (1995) Am. J. Obstet. Gynecol. , vol.172 , pp. 1837-1843
    • Strawn, E.Y.1    Novy, M.J.2    Burry, K.A.3    Bethea, C.L.4
  • 119
    • 74049154789 scopus 로고    scopus 로고
    • Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth
    • Suo G., Jiang Y., Cowan B., Wang J.Y. Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth. Biol. Reprod. 2009, 81:749-758.
    • (2009) Biol. Reprod. , vol.81 , pp. 749-758
    • Suo, G.1    Jiang, Y.2    Cowan, B.3    Wang, J.Y.4
  • 120
    • 0031086048 scopus 로고    scopus 로고
    • The expression of transforming growth factor-beta s and TGF-beta receptor mRNA and protein and the effect of TGF-beta s on human myometrial smooth muscle cells in vitro
    • Tang X.M., Dou Q., Zhao Y., McLean F., Davis J., Chegini N. The expression of transforming growth factor-beta s and TGF-beta receptor mRNA and protein and the effect of TGF-beta s on human myometrial smooth muscle cells in vitro. Mol. Hum. Reprod. 1997, 3:233-240.
    • (1997) Mol. Hum. Reprod. , vol.3 , pp. 233-240
    • Tang, X.M.1    Dou, Q.2    Zhao, Y.3    McLean, F.4    Davis, J.5    Chegini, N.6
  • 121
    • 67649637547 scopus 로고    scopus 로고
    • Treatment of menorrhagia with the levonorgestrel releasing intrauterine system: effects on ovarian function and uterus
    • Tasci Y., Caglar G.S., Kayikcioglu F., Cengiz H., Yagci B., Gunes M. Treatment of menorrhagia with the levonorgestrel releasing intrauterine system: effects on ovarian function and uterus. Arch. Gynecol. Obstet. 2009, 280:39-42.
    • (2009) Arch. Gynecol. Obstet. , vol.280 , pp. 39-42
    • Tasci, Y.1    Caglar, G.S.2    Kayikcioglu, F.3    Cengiz, H.4    Yagci, B.5    Gunes, M.6
  • 122
    • 79955073599 scopus 로고    scopus 로고
    • Establishment of a novel xenograft model for human uterine leiomyoma in immunodeficient mice
    • Tsuiji K., Takeda T., Li B., Kondo A., Ito M., Yaegashi N. Establishment of a novel xenograft model for human uterine leiomyoma in immunodeficient mice. Tohoku J. Exp. Med. 2010, 222:55-61.
    • (2010) Tohoku J. Exp. Med. , vol.222 , pp. 55-61
    • Tsuiji, K.1    Takeda, T.2    Li, B.3    Kondo, A.4    Ito, M.5    Yaegashi, N.6
  • 123
    • 28244486944 scopus 로고    scopus 로고
    • Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells
    • Vallejo G., Ballare C., Baranao J.L., Beato M., Saragueta P. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Mol. Endocrinol. 2005, 19:3023-3037.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 3023-3037
    • Vallejo, G.1    Ballare, C.2    Baranao, J.L.3    Beato, M.4    Saragueta, P.5
  • 125
    • 0027168668 scopus 로고
    • Messenger ribonucleic acid expression of the insulin-like growth factors and their binding proteins in uterine fibroids and myometrium
    • Vollenhoven B.J., Herington A.C., Healy D.L. Messenger ribonucleic acid expression of the insulin-like growth factors and their binding proteins in uterine fibroids and myometrium. J. Clin. Endocrinol. Metab. 1993, 76:1106-1110.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1106-1110
    • Vollenhoven, B.J.1    Herington, A.C.2    Healy, D.L.3
  • 126
    • 33745855890 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFbeta3 and their receptors in cultured uterine leiomyoma cells
    • Wang J., Ohara N., Wang Z., Chen W., Morikawa A., Sasaki H., DeManno D.A., Chwalisz K., Maruo T. A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFbeta3 and their receptors in cultured uterine leiomyoma cells. Hum. Reprod. 2006, 21:1869-1877.
    • (2006) Hum. Reprod. , vol.21 , pp. 1869-1877
    • Wang, J.1    Ohara, N.2    Wang, Z.3    Chen, W.4    Morikawa, A.5    Sasaki, H.6    DeManno, D.A.7    Chwalisz, K.8    Maruo, T.9
  • 127
    • 55849111515 scopus 로고    scopus 로고
    • MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas
    • Wei J.J., Soteropoulos P. MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas. Semin. Reprod. Med. 2008, 26:515-521.
    • (2008) Semin. Reprod. Med. , vol.26 , pp. 515-521
    • Wei, J.J.1    Soteropoulos, P.2
  • 128
    • 0037051711 scopus 로고    scopus 로고
    • The effect on menstrual blood loss in women with uterine fibroids of a novel "frameless" intrauterine levonorgestrel-releasing drug delivery system: a pilot study
    • Wildemeersch D., Schacht E. The effect on menstrual blood loss in women with uterine fibroids of a novel "frameless" intrauterine levonorgestrel-releasing drug delivery system: a pilot study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2002, 102:74-79.
    • (2002) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.102 , pp. 74-79
    • Wildemeersch, D.1    Schacht, E.2
  • 129
    • 57349169309 scopus 로고    scopus 로고
    • Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy
    • Wilkens J., Chwalisz K., Han C., Walker J., Cameron I.T., Ingamells S., Lawrence A.C., Lumsden M.A., Hapangama D., Williams A.R., Critchley H.O. Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy. J. Clin. Endocrinol. Metab. 2008, 93:4664-4671.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4664-4671
    • Wilkens, J.1    Chwalisz, K.2    Han, C.3    Walker, J.4    Cameron, I.T.5    Ingamells, S.6    Lawrence, A.C.7    Lumsden, M.A.8    Hapangama, D.9    Williams, A.R.10    Critchley, H.O.11
  • 130
    • 67449168270 scopus 로고    scopus 로고
    • Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN
    • Wilkens J., Williams A.R., Chwalisz K., Han C., Cameron I.T., Critchley H.O. Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN. Hum. Reprod. 2009, 24:1036-1044.
    • (2009) Hum. Reprod. , vol.24 , pp. 1036-1044
    • Wilkens, J.1    Williams, A.R.2    Chwalisz, K.3    Han, C.4    Cameron, I.T.5    Critchley, H.O.6
  • 131
    • 34447305522 scopus 로고    scopus 로고
    • The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata
    • Williams, A.R., Critchley, H.O., Osei, J., Ingamells, S., Cameron, I.T., Han, C., Chwalisz, K., 2007. The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata. Hum Reprod.
    • (2007) Hum Reprod.
    • Williams, A.R.1    Critchley, H.O.2    Osei, J.3    Ingamells, S.4    Cameron, I.T.5    Han, C.6    Chwalisz, K.7
  • 132
    • 0037323641 scopus 로고    scopus 로고
    • Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women
    • Worda C., Sator M.O., Schneeberger C., Jantschev T., Ferlitsch K., Huber J.C. Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women. Hum. Reprod. 2003, 18:262-266.
    • (2003) Hum. Reprod. , vol.18 , pp. 262-266
    • Worda, C.1    Sator, M.O.2    Schneeberger, C.3    Jantschev, T.4    Ferlitsch, K.5    Huber, J.C.6
  • 133
    • 14044251610 scopus 로고    scopus 로고
    • Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells
    • Xu Q., Takekida S., Ohara N., Chen W., Sitruk-Ware R., Johansson E.D., Maruo T. Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. J. Clin. Endocrinol. Metab. 2005, 90:953-961.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 953-961
    • Xu, Q.1    Takekida, S.2    Ohara, N.3    Chen, W.4    Sitruk-Ware, R.5    Johansson, E.D.6    Maruo, T.7
  • 134
    • 33749545197 scopus 로고    scopus 로고
    • Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells
    • Xu Q., Ohara N., Chen W., Liu J., Sasaki H., Morikawa A., Sitruk-Ware R., Johansson E.D., Maruo T. Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Hum. Reprod. 2006, 21:2408-2416.
    • (2006) Hum. Reprod. , vol.21 , pp. 2408-2416
    • Xu, Q.1    Ohara, N.2    Chen, W.3    Liu, J.4    Sasaki, H.5    Morikawa, A.6    Sitruk-Ware, R.7    Johansson, E.D.8    Maruo, T.9
  • 136
    • 40949109661 scopus 로고    scopus 로고
    • Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells
    • Xu Q., Ohara N., Liu J., Amano M., Sitruk-Ware R., Yoshida S., Maruo T. Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells. Mol. Hum. Reprod. 2008, 14:181-191.
    • (2008) Mol. Hum. Reprod. , vol.14 , pp. 181-191
    • Xu, Q.1    Ohara, N.2    Liu, J.3    Amano, M.4    Sitruk-Ware, R.5    Yoshida, S.6    Maruo, T.7
  • 137
    • 77955577648 scopus 로고    scopus 로고
    • Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells
    • Xu Q., Qiu L., Zhu L., Luo L., Xu C. Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Contraception 2010, 82:301-308.
    • (2010) Contraception , vol.82 , pp. 301-308
    • Xu, Q.1    Qiu, L.2    Zhu, L.3    Luo, L.4    Xu, C.5
  • 138
    • 1842585075 scopus 로고    scopus 로고
    • Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cells
    • Yamada T., Nakago S., Kurachi O., Wang J., Takekida S., Matsuo H., Maruo T. Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cells. Hum. Reprod. 2004, 19:815-821.
    • (2004) Hum. Reprod. , vol.19 , pp. 815-821
    • Yamada, T.1    Nakago, S.2    Kurachi, O.3    Wang, J.4    Takekida, S.5    Matsuo, H.6    Maruo, T.7
  • 140
    • 33846963526 scopus 로고    scopus 로고
    • Requirements of phosphatidylinositol-3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma- and myometrium-derived cell lines
    • Yin X.J., Wang G., Khan-Dawood F.S. Requirements of phosphatidylinositol-3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma- and myometrium-derived cell lines. Am. J. Obstet. Gynecol. 2007, 196:176 e1-5.
    • (2007) Am. J. Obstet. Gynecol. , vol.196
    • Yin, X.J.1    Wang, G.2    Khan-Dawood, F.S.3
  • 142
    • 70350680744 scopus 로고    scopus 로고
    • Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A:B
    • Ying Z., Weiyuan Z. Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A:B. Gynecol. Endocrinol. 2009, 25:520-523.
    • (2009) Gynecol. Endocrinol. , vol.25 , pp. 520-523
    • Ying, Z.1    Weiyuan, Z.2
  • 143
    • 44649107576 scopus 로고    scopus 로고
    • Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas
    • Yu L., Saile K., Swartz C.D., He H., Zheng X., Kissling G.E., Di X., Lucas S., Robboy S.J., Dixon D. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Mol. Med. 2008, 14:264-275.
    • (2008) Mol. Med. , vol.14 , pp. 264-275
    • Yu, L.1    Saile, K.2    Swartz, C.D.3    He, H.4    Zheng, X.5    Kissling, G.E.6    Di, X.7    Lucas, S.8    Robboy, S.J.9    Dixon, D.10
  • 144
    • 77951517877 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma
    • Yu, L., Moore, A.B., Dixon, D., 2010. Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. Semin. Reprod. Med. 28, 180-203.
    • (2010) Semin. Reprod. Med. , vol.28 , pp. 180-203
    • Yu, L.1    Moore, A.B.2    Dixon, D.3
  • 145
    • 77957866076 scopus 로고    scopus 로고
    • Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas
    • Zavadil, J., Ye, H., Liu, Z., Wu, J., Lee, P., Hernando, E., Soteropoulos, P., Toruner, G.A., Wei, J.J., 2010. Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas. PLoS One 5, e12362.
    • (2010) PLoS One , vol.5
    • Zavadil, J.1    Ye, H.2    Liu, Z.3    Wu, J.4    Lee, P.5    Hernando, E.6    Soteropoulos, P.7    Toruner, G.A.8    Wei, J.J.9
  • 146
    • 58249122148 scopus 로고    scopus 로고
    • Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
    • Zhu M.L., Kyprianou N. Androgen receptor and growth factor signaling cross-talk in prostate cancer cells. Endocr. Relat. Cancer 2008, 15:841-849.
    • (2008) Endocr. Relat. Cancer , vol.15 , pp. 841-849
    • Zhu, M.L.1    Kyprianou, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.