Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri

Journal of Steroid Biochemistry and Molecular Biology

Volumn 103, Issue 2, 2007, Pages 196-199

  Kovács, Kálmán A ^a   Lengyel, Ferenc ^a   Vértes, Zsuzsanna ^a   Környei, József L ^a   Gocze, Péter M ^a   Sumegi, Balazs ^a   Szabó, István ^a   Vértes, Marietta ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Enhanced PTEN phosphorylation; Impaired PTEN Akt signalling; Leiomyoma

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN; PROTEIN KINASE B; SEX HORMONE;

ADULT; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN TISSUE; MENOPAUSE; MENSTRUAL CYCLE; PROTEIN CONTENT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UTERUS MYOMA;

ADULT; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; HUMANS; LEIOMYOMA; MIDDLE AGED; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTEIN KINASES; PTEN PHOSPHOHYDROLASE; UTERINE NEOPLASMS;

EID: 33846437521     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.08.006     Document Type: Article

References (12)

1. Maruo T., Ohara N., Wang J., and Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum. Reprod. Update 10 (2004) 207-220
2. Simoncini T., and Genazzani A.R. Non-genomic actions of sex steroid hormones. Eur. J. Endocrinol. 148 (2003) 281-292
3. Lengyel F., Vertes Z., Kovacs K.A., Kornyei J.L., Sumegi B., and Vertes M. Expression and activation of Akt/protein kinase B in sexually immature and mature rat uterus. J. Steroid Biochem. Mol. Biol. 91 (2004) 285-288
4. Kovacs K.A., Lengyel F., Kornyei J.L., Vertes Z., Szabo I., Sumegi B., and Vertes M. Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium. J. Steroid Biochem. Mol. Biol. 87 (2003) 233-240
5. Kovacs K.A., Oszter A., Gocze P.M., Kornyei J.L., and Szabo I. Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium. Mol. Hum. Reprod. 7 (2001) 1085-1091
6. Vazquez F., Ramaswamy S., Nakamura N., and Sellers W.R. Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell. Biol. 20 (2000) 5010-5018
7. Maehama T., and Dixon J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 (1998) 13375-13378
8. Chow L.M., and Baker S.J. PTEN function in normal and neoplastic growth. Cancer Lett. 241 (2006) 184-196
9. Gericke A., Munson M., and Ross A.H. Regulation of the PTEN phosphatase. Gene 374 (2006) 1-9
10. Castano E., Vorojeikina D.P., and Notides A.C. Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation. Biochem. J. 326 Pt 1 (1997) 149-157
11. Guzeloglu-Kayisli O., Kayisli U.A., Al-Rejjal R., Zheng W., Luleci G., and Arici A. Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium. J. Clin. Endocrinol. Metab. 88 (2003) 5017-5026
12. Mutter G.L., Lin M.C., Fitzgerald J.T., Kum J.B., and Eng C. Changes in endometrial PTEN expression throughout the human menstrual cycle. J. Clin. Endocrinol. Metab. 85 (2000) 2334-2338