Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle

Reproductive Sciences

Volumn 14, Issue 7, 2007, Pages 678-686

  Kayisli, Umit A ^b   Berkkanoglu, Murat ^b   Kizilay, Gulnur ^b   Senturk, Levent ^b   Arici, Aydin ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Fas ligand; Leiomyoma; Myometrium; PCNA; PTEN

Indexed keywords

CYCLINE; FAS LIGAND; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH FACTOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SEX HORMONE; FASLG PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; MENSTRUAL CYCLE; MITOGENESIS; MYOMETRIUM; PARACRINE SIGNALING; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; BIOSYNTHESIS; CELL GROWTH; CYTOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; UTERUS CANCER;

ADULT; APOPTOSIS; CELL GROWTH PROCESSES; FAS LIGAND PROTEIN; FEMALE; HUMANS; LEIOMYOMA; MENSTRUAL CYCLE; MIDDLE AGED; MYOMETRIUM; PROLIFERATING CELL NUCLEAR ANTIGEN; PTEN PHOSPHOHYDROLASE; UTERINE NEOPLASMS;

EID: 38449090730     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107305866     Document Type: Article

References (38)

1. Kierszenbaum A. Follicle development and menstrual cycle: uterus. In: Histology and Cell Biology: An Introduction to Pathology. St Louis, MO: Mosby ; 2002: 565-585.
2. Flake GP, Andersen J., Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003 ; 111: 1037-1054.
3. Sozen I., Arici A. Cellular biology of myomas: interaction of sex steroids with cytokines and growth factors. Obstet Gynecol Clin North Am. 2006 ; 33: 41-58.
4. Palomba S., Orio F. Jr, Russo T., et al. Antiproliferative and proapoptotic effects of raloxifene on uterine leiomyomas in postmenopausal women. Fertil Steril. 2005 ; 84: 154-161.
5. Wei JJ, Zhang XM, Chiriboga L., Yee H., Perle MA, Mittal K. Spatial differences in biologic activity of large uterine leiomyomata. Fertil Steril. 2006 ; 85: 179-187.
6. Sozen I., Arici A. Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata. Fertil Steril. 2002 ; 78: 1-12.
7. Liang M., Wang H., Zhang Y., Lu S., Wang Z. Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata. Cancer Biol Ther. 2006 ; 5: 28-33.
8. Cramer SF, Horiszny JA, Leppert P. Epidemiology of uterine leiomyomas: with an etiologic hypothesis. J Reprod Med. 1995 ; 40: 595-600.
9. Nagata S., Golstein P. The Fas death factor. Science. 1995 ; 267: 1449-1456.
10. Leslie NR, Downes CP PTEN: the down side of PI 3-kinase signalling. Cell Signal. 2002 ; 14: 285-295.
11. Han SY, Kato H., Kato S., et al. Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res. 2000 ; 60: 3147-3151.
12. Myers MP, Pass I., Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci U S A. 1998 ; 95: 13513-13518.
13. Majka J., Burgers PM The PCNA-RFC families of DNA clamps and clamp loaders. Prog Nucleic Acid Res Mol Biol. 2004 ; 78: 227-260.
14. Maga G., Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 ; 116: 3051-3060.
15. Goumenou A., Panayiotides I., Mahutte NG, Matalliotakis I., Fragouli Y., Arici A. Immunohistochemical expression of p53, MDM2, and p21Waf1 oncoproteins in endometriomas but not adenomyosis. J Soc Gynecol Investig. 2005 ; 12: 263-266.
16. Goumenou AG, Matalliotakis IM, Tzardi M., Fragouli YG, Mahutte NG, Arici A. Apoptosis and differential expression of apoptosis-related proteins in endometriotic glandular and stromal cells. J Soc Gynecol Investig. 2004 ; 11: 318-322.
17. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975 ; 122: 262-263.
18. Kayisli UA, Selam B., Demir R., Arici A. Expression of vasodilator-stimulated phosphoprotein in human placenta: possible implications in trophoblast invasion. Mol Hum Reprod. 2002 ; 8: 88-94.
19. Cook JD, Walker CL T reatment strategies for uterine leiomyoma: the role of hormonal modulation. Semin Reprod Med. 2004 ; 22: 105-111.
20. Burroughs KD, Kiguchi K., Howe SR, et al. Regulation of apoptosis in uterine leiomyomata. Endocrinology. 1997 ; 138: 3056-3064.
21. Shynlova O., Oldenhof A., Dorogin A., et al. Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation. Biol Reprod. 2006 ; 74: 839-849.
22. Huang SC, Tang MJ, Hsu KF, Cheng YM, Chou CY Fas and its ligand, caspases, and bcl-2 expression in gonadotropin-releasing hormone agonist-treated uterine leiomyoma. J Clin Endocrinol Metab. 2002 ; 87: 4580-4586.
23. Wang Y., Matsuo H., Kurachi O., Maruo T. Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells. Eur J Endocrinol. 2002 ; 146: 447-456.
24. Maruo T., Ohara N., Wang J., Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update. 2004 ; 10: 207-220.
25. Selam B., Kayisli UA, Mulayim N., Arici A. Regulation of Fas ligand expression by estradiol and progesterone in human endometrium. Biol Reprod. 2001 ; 65: 979-985.
26. Bourlev V., Pavlovitch S., Stygar D., Volkov N., Lindblom B., Olovsson M. Different proliferative and apoptotic activity in peripheral versus central parts of human uterine leiomyomas. Gynecol Obstet Invest. 2003 ; 55: 199-204.
27. Kawaguchi K., Fujii S., Konishi I., Nanbu Y., Nonogaki H., Mori T. Mitotic activity in uterine leiomyomas during the menstrual cycle. Am J Obstet Gynecol. 1989 ; 160: 637-641.
28. Shimomura Y., Matsuo H., Samoto T., Maruo T. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab. 1998 ; 83: 2192-2198.
29. Lamminen S., Rantala I., Helin H., Rorarius M., Tuimala R. Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysis. Gynecol Obstet Invest. 1992 ; 34: 111-114.
30. Zaslawski R., Surowiak P., Dziegiel P., Pretnik L., Zabel M. Analysis of the expression of estrogen and progesterone receptors, and of PCNA and Ki67 proliferation antigens, in uterine myomata cells in relation to the phase of the menstrual cycle. Med Sci Monit. 2001 ; 7: 908-913.
31. Chegini N., Verala J., Luo X., Xu J., Williams RS Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy. J Soc Gynecol Investig. 2003 ; 10: 161-171.
32. Dixon D., Flake GP, Moore AB, et al. Cell proliferation and apoptosis in human uterine leiomyomas and myometria. Virchows Arch. 2002 ; 441: 53-62.
33. Buttram VC Jr, Reiter RC Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981 ; 36: 433-445.
34. Mutter GL, Ince TA, Baak JP, Kust GA, Zhou XP, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res. 2001 ; 61: 4311-4314.
35. Guzeloglu-Kayisli O., Kayisli UA, Al-Rejjal R., Zheng W., Luleci G., Arici A. Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium. J Clin Endocrinol Metab. 2003 ; 88: 5017-5026.
36. Kovacs KA, Lengyel F., Kornyei JL, et al. Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium. J Steroid Biochem Mol Biol. 2003 ; 87: 233-240.
37. Wei J., Chiriboga L., Mizuguchi M., Yee H., Mittal K. Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomata. Mod Pathol. 2005 ; 18: 179-188.
38. Hussein-Fikret S., Fuller PJ, Gargett CE Expression of steroid receptor coactivators in cultured cells from paired myometrial and fibroid tissues. J Soc Gynecol Investig. 2005 ; 12: 445-451.