Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A:B

Gynecological Endocrinology

Volumn 25, Issue 8, 2009, Pages 520-523

  Ying, Zhao ^a   Weiyuan, Zhang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

IGF I mRNA; Leiomyoma; Myometrium; PRA mRNA; PRB mRNA; Uterus

Indexed keywords

MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; SOMATOMEDIN C;

ADULT; ARTICLE; CLINICAL ARTICLE; CORRELATIONAL STUDY; DOWN REGULATION; DRUG INHIBITION; DRUG MECHANISM; FEMALE; HUMAN; HUMAN TISSUE; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; UTERUS MYOMA;

ADULT; DOWN-REGULATION; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LEIOMYOMA; MIDDLE AGED; MYOMETRIUM; PROGESTERONE; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UTERINE NEOPLASMS;

EID: 70350680744     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590902972117     Document Type: Article

References (11)

1. Maruo T, Laoag-Fernandez JB, Pakarinen PM, Urakoshi HS, Pitz IM, Johansson E. Effects of progesterone on uterine leiomyoma growth and apoptosis. Steroids 2000;65:585-592.
2. Maruo T, Ohara N, Wang J, Matsuo H. Sex steroid regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update 2004;10:207-220.
3. O'Malley B.W. Steroid hormone receptors as transactivators of gene expression. Breast Cancer Res Treat 1991;18:67-71.
4. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 1990;9:1603-1614.
5. Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Lydon JP, Conneely OM. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 2000;289:1751-1754.
6. Viville B, Charnock-Johes DS, Sharkey AM, Wetzka B, Smith SK. Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyoma and adjacent myometrium. Hum Reprod 1997;12:815-822.
7. Fujimoto J, Hirose R, Jchigo S, Sakaguchi H, Li Y, Tamaya T. Expression of progesterone receptor form A and B mRNAs in uterine leiomyoma. Tumor Biol 1998;19:126-131.
8. Kim DT, Lee TK, Lim IS, Kim H, Lee YC, Kim CH. Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. Toxicol Appl Pharmacol 2005;3:213-224.
9. Phelan JP. Myomas and pregnancy. Obset Gynecol Clin North Am 1995;22:801-805.
10. Lange CA. Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word? Mol Endocrinol 2004;18:269-278.
11. Faivre E, Skildam A, Pierson-Mullang L, Lange CA. Integration of progesterone receptor mediated rapid signaling and nuclear action in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators. Steroids 2005;70:418-426.