6-alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4479-4487

  Hour, M J ^a   Huang, L J ^a   Kuo, S C ^a   Xia, Y ^b   Bastow, K ^c   Nakanishi, Y ^c   Hamel, E ^c   Lee, K H ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 4 QUINOLONE; 2,3 DIHYDRO 3' METHOXY 2 PHENYL 4 QUINAZOLINONE; 6 AMINOQUINAZOLINONE; COLCHICINE; COMBRETASTATIN A4; KETONE; PODOPHYLLOTOXIN; QUINAZOLINONE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL LINE; CYTOTOXICITY; MICROTUBULE; MITOSIS; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BIOPOLYMERS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRROLIDINES; QUINAZOLINES; QUINAZOLINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

EID: 0034676319     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000151c     Document Type: Article

References (22)

1. The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics
2. Paclitaxel (Taxol) and docetaxel (Taxotere): Not simply two of a kind
3. Interactions of colchicine with tubulin
4. Colchicine and its analogues: Recent findings
5. Synthesis and cytotoxicity of 1,6,7,8- and 4′-substituted 2-phenyl-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin
6. 2′,3′,4′,5′,5,6,7-Substituted 2-phenyl-4-quinolones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization
7. Synthesis and biological evaluation of 3′,6′,7-substituted 2-phenyl-4-quinolones as antimitotic antitumor agents
8. Synthesis and biological evaluation of 6,7,2′,3′,4′-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quin olones as a new class of antimitotic agents
9. 2′,3′,4′,5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization
10. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antimitotic antitumor agents that inhibit tubulin polymerization
11. Substituted 2,3-dihydro-4(1H)-quinazolinones. A new class of inhibitors of cell multiplication
12. Antitumor effects of the antispermatogenic agent, 2,3-dihydro-2-(1-naphthyl)-4(1H)-quinazolinones
13. Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin
14. Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization
15. Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)-one
16. Synthesis and biological evaluation of substituted 2-arylquinazolinones
17. Recent advances in the discovery and development of quinolones and analogues as antitumor agents
18. The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis captitata: Ursolic acid and related derivatives
19. Status of the NCI preclinical antitumor drug discovery screen
20. Feasibility of a high-flux anticancer drug screen utilizing a derived panel of human tumor cell lines in culture
21. Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles
22. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antitmitotic agent, with tubulin and effects of analogues on the growth of MCF-7 breast cancer cells