메뉴 건너뛰기




Volumn 86, Issue 7, 2012, Pages 3411-3421

Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; LABORATORY OF GENETICS AND PHYSIOLOGY 2 PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; RNA HELICASE; UNCLASSIFIED DRUG; VIRUS PROTEIN V;

EID: 84861304915     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06405-11     Document Type: Article
Times cited : (110)

References (54)
  • 1
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I-dependent sensing of poly(dA: dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser A, et al. 2009. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10:1065-1072.
    • (2009) Nat. Immunol. , vol.10 , pp. 1065-1072
    • Ablasser, A.1
  • 2
    • 10344259136 scopus 로고    scopus 로고
    • The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFNbeta promoter
    • Andrejeva J, et al. 2004. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFNbeta promoter. Proc. Natl. Acad. Sci. U. S. A. 101:17264 -17269.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 17264-17269
    • Andrejeva, J.1
  • 3
    • 65649083024 scopus 로고    scopus 로고
    • Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2
    • Bamming D, Horvath CM. 2009. Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2. J. Biol. Chem. 284:9700 -9712.
    • (2009) J. Biol. Chem. , vol.284 , pp. 9700-9712
    • Bamming, D.1    Horvath, C.M.2
  • 4
    • 77957997708 scopus 로고    scopus 로고
    • Preference of RIG-I for short viralRNAmolecules in infected cells revealed by next-generation sequencing
    • Baum A, Sachidanandam R, Garcia-Sastre A. 2010. Preference of RIG-I for short viralRNAmolecules in infected cells revealed by next-generation sequencing. Proc. Natl. Acad. Sci. U. S. A. 107:16303-16308.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 16303-16308
    • Baum, A.1    Sachidanandam, R.2    Garcia-Sastre, A.3
  • 5
    • 78951490665 scopus 로고    scopus 로고
    • The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R
    • Boonyaratanakornkit J, et al. 2011. The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R. J. Virol. 85: 1495-1506.
    • (2011) J. Virol. , vol.85 , pp. 1495-1506
    • Boonyaratanakornkit, J.1
  • 6
    • 77957658503 scopus 로고    scopus 로고
    • Heterocellular induction of interferon by negativesense RNA viruses
    • Chen S, et al. 2010. Heterocellular induction of interferon by negativesense RNA viruses. Virology 407:247-255.
    • (2010) Virology , vol.407 , pp. 247-255
    • Chen, S.1
  • 7
    • 33846863325 scopus 로고    scopus 로고
    • mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
    • Childs K, et al. 2007. mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. Virology 359:190 -200.
    • (2007) Virology , vol.359 , pp. 190-200
    • Childs, K.1
  • 8
    • 59749095300 scopus 로고    scopus 로고
    • Mechanism of mda-5 inhibition by paramyxovirus V proteins
    • Childs KS, Andrejeva J, Randall RE, Goodbourn S. 2009. Mechanism of mda-5 inhibition by paramyxovirus V proteins. J. Virol. 83:1465- 1473.
    • (2009) J. Virol. , vol.83 , pp. 1465-1473
    • Childs, K.S.1    Andrejeva, J.2    Randall, R.E.3    Goodbourn, S.4
  • 9
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu YH, Macmillan JB, Chen ZJ. 2009. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138:576 -591.
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 10
    • 33744791510 scopus 로고    scopus 로고
    • Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus
    • Gitlin L, et al. 2006. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. U. S. A. 103:8459-8464.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 8459-8464
    • Gitlin, L.1
  • 11
    • 77649221014 scopus 로고    scopus 로고
    • Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo
    • Gitlin L, et al. 2010. Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog. 6:e1000734.
    • (2010) PLoS Pathog , vol.6
    • Gitlin, L.1
  • 12
    • 0036924472 scopus 로고    scopus 로고
    • Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctionalV protein blocks both interferon-beta induction and interferon signaling
    • He B, et al. 2002. Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctionalV protein blocks both interferon-beta induction and interferon signaling. Virology 303:15-32.
    • (2002) Virology , vol.303 , pp. 15-32
    • He, B.1
  • 13
    • 33750976374 scopus 로고    scopus 로고
    • 5'-Triphosphate RNA is the ligand for RIG-I
    • Hornung V, et al. 2006. 5'-Triphosphate RNA is the ligand for RIG-I. Science 314:994 -997.
    • (2006) Science , vol.314 , pp. 994-997
    • Hornung, V.1
  • 14
    • 72849147109 scopus 로고    scopus 로고
    • Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells
    • Ikegame S, et al. 2010. Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells. J. Virol. 84:372-379.
    • (2010) J. Virol. , vol.84 , pp. 372-379
    • Ikegame, S.1
  • 15
    • 0019780093 scopus 로고
    • The characteristics required for a Sendai virus preparation to induce high levels of interferon in human lymphoblastoid cells
    • Johnston MD. 1981. The characteristics required for a Sendai virus preparation to induce high levels of interferon in human lymphoblastoid cells. J. Gen. Virol. 56:175-184.
    • (1981) J. Gen. Virol. , vol.56 , pp. 175-184
    • Johnston, M.D.1
  • 16
    • 46949097299 scopus 로고    scopus 로고
    • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    • Kato H, et al. 2008. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 205:1601-1610.
    • (2008) J. Exp. Med. , vol.205 , pp. 1601-1610
    • Kato, H.1
  • 17
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H, et al. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-105.
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1
  • 18
    • 79956220701 scopus 로고    scopus 로고
    • Failure to activate the IFN-beta promoter by a paramyxovirus lacking an interferon antagonist
    • Killip MJ, et al. 2011. Failure to activate the IFN-beta promoter by a paramyxovirus lacking an interferon antagonist. Virology 415:39-46.
    • (2011) Virology , vol.415 , pp. 39-46
    • Killip, M.J.1
  • 19
    • 34250357239 scopus 로고    scopus 로고
    • Bovine parainfluenza virus type 3 accessory proteins that suppress beta interferon production
    • Komatsu T, Takeuchi K, Gotoh B. 2007. Bovine parainfluenza virus type 3 accessory proteins that suppress beta interferon production. Microbes Infect. 9:954 -962.
    • (2007) Microbes Infect , vol.9 , pp. 954-962
    • Komatsu, T.1    Takeuchi, K.2    Gotoh, B.3
  • 20
    • 33845431988 scopus 로고    scopus 로고
    • RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2
    • Komuro A, Horvath CM. 2006. RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. J. Virol. 80:12332-12342.
    • (2006) J. Virol. , vol.80 , pp. 12332-12342
    • Komuro, A.1    Horvath, C.M.2
  • 21
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T, Akira S. 2011. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30:16 -34.
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 22
    • 67651232539 scopus 로고    scopus 로고
    • Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5
    • Li X, et al. 2009. Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5. Arch. Biochem. Biophys. 488:23-33.
    • (2009) Arch. Biochem. Biophys. , vol.488 , pp. 23-33
    • Li, X.1
  • 23
    • 67649413594 scopus 로고    scopus 로고
    • The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
    • Li X, et al. 2009. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. J. Biol. Chem. 284:13881-13891.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13881-13891
    • Li, X.1
  • 24
    • 79952325540 scopus 로고    scopus 로고
    • Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate
    • Lu C, Ranjith-Kumar CT, Hao L, Kao CC, Li P. 2011. Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate. Nucleic Acids Res. 39:1565-1575.
    • (2011) Nucleic Acids Res , vol.39 , pp. 1565-1575
    • Lu, C.1    Ranjith-Kumar, C.T.2    Hao, L.3    Kao, C.C.4    Li, P.5
  • 25
    • 47249132062 scopus 로고    scopus 로고
    • Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1
    • Lu LL, Puri M, Horvath CM, Sen GC. 2008. Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. J. Biol. Chem. 283:14269- 14276.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14269-14276
    • Lu, L.L.1    Puri, M.2    Horvath, C.M.3    Sen, G.C.4
  • 26
    • 79952125382 scopus 로고    scopus 로고
    • Activation of IFN-beta expression by a viral mRNA through RNase L and MDA5
    • Luthra P, Sun D, Silverman RH, He B. 2011. Activation of IFN-beta expression by a viral mRNA through RNase L and MDA5. Proc. Natl. Acad. Sci. U. S. A. 108:2118 -2123.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 2118-2123
    • Luthra, P.1    Sun, D.2    Silverman, R.H.3    He, B.4
  • 27
    • 1642471882 scopus 로고    scopus 로고
    • The human parainfluenza virus type 3 (HPIV 3) C protein inhibits viral transcription
    • Malur AG, Hoffman MA, Banerjee AK. 2004. The human parainfluenza virus type 3 (HPIV 3) C protein inhibits viral transcription. Virus Res. 99:199 -204.
    • (2004) Virus Res , vol.99 , pp. 199-204
    • Malur, A.G.1    Hoffman, M.A.2    Banerjee, A.K.3
  • 28
    • 67649126159 scopus 로고    scopus 로고
    • Crystallization and preliminary crystallographic studies of human RIG-I in complex with double-stranded RNA
    • Moon H, Choe J. 2009. Crystallization and preliminary crystallographic studies of human RIG-I in complex with double-stranded RNA. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65:648-650.
    • (2009) Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. , vol.65 , pp. 648-650
    • Moon, H.1    Choe, J.2
  • 29
    • 46949102571 scopus 로고    scopus 로고
    • Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response
    • Murali A, et al. 2008. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. J. Biol. Chem. 283: 15825-15833.
    • (2008) J. Biol. Chem. , vol.283 , pp. 15825-15833
    • Murali, A.1
  • 30
    • 50149115159 scopus 로고    scopus 로고
    • Measles virus circumvents the host interferon response by different actions of the C and V proteins
    • Nakatsu Y, et al. 2008. Measles virus circumvents the host interferon response by different actions of the C and V proteins. J. Virol. 82:8296- 8306.
    • (2008) J. Virol. , vol.82 , pp. 8296-8306
    • Nakatsu, Y.1
  • 31
    • 67650439286 scopus 로고    scopus 로고
    • A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2
    • Parisien JP, et al. 2009. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. J. Virol. 83: 7252-7260.
    • (2009) J. Virol. , vol.83 , pp. 7252-7260
    • Parisien, J.P.1
  • 32
    • 33750984771 scopus 로고    scopus 로고
    • RIG-I-mediated antiviral responses to singlestranded RNA bearing 5'-phosphates
    • Pichlmair A, et al. 2006. RIG-I-mediated antiviral responses to singlestranded RNA bearing 5'-phosphates. Science 314:997-1001.
    • (2006) Science , vol.314 , pp. 997-1001
    • Pichlmair, A.1
  • 33
    • 70349728538 scopus 로고    scopus 로고
    • Activation of MDA5 requires higher-order RNA structures generated during virus infection
    • Pichlmair A, et al. 2009. Activation of MDA5 requires higher-order RNA structures generated during virus infection. J. Virol. 83:10761-10769.
    • (2009) J. Virol. , vol.83 , pp. 10761-10769
    • Pichlmair, A.1
  • 34
    • 64549126847 scopus 로고    scopus 로고
    • The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
    • Pippig DA, et al. 2009. The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA. Nucleic Acids Res. 37:2014 -2025.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2014-2025
    • Pippig, D.A.1
  • 35
    • 0036920154 scopus 로고    scopus 로고
    • The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta
    • Poole E, He B, Lamb RA, Randall RE, Goodbourn S. 2002. The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta. Virology 303:33- 46.
    • (2002) Virology , vol.303 , pp. 33-46
    • Poole, E.1    He, B.2    Lamb, R.A.3    Randall, R.E.4    Goodbourn, S.5
  • 36
    • 77957941317 scopus 로고    scopus 로고
    • Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference
    • Ramachandran A, Horvath CM. 2010. Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference. J. Virol. 84: 11152-11163.
    • (2010) J. Virol. , vol.84 , pp. 11152-11163
    • Ramachandran, A.1    Horvath, C.M.2
  • 37
    • 36348940608 scopus 로고    scopus 로고
    • Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
    • Randall RE, Goodbourn S. 2008. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89:1- 47.
    • (2008) J. Gen. Virol. , vol.89 , pp. 1-47
    • Randall, R.E.1    Goodbourn, S.2
  • 38
    • 26844503987 scopus 로고    scopus 로고
    • The RNA helicase Lgp2 inhibits TLRindependent sensing of viral replication by retinoic acid-inducible gene-I
    • Rothenfusser S, et al. 2005. The RNA helicase Lgp2 inhibits TLRindependent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol. 175:5260 -5268.
    • (2005) J. Immunol. , vol.175 , pp. 5260-5268
    • Rothenfusser, S.1
  • 39
    • 33846307026 scopus 로고    scopus 로고
    • Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
    • Saito T, et al. 2007. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. U. S. A. 104:582-587.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 582-587
    • Saito, T.1
  • 40
    • 76549109497 scopus 로고    scopus 로고
    • LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses
    • Satoh T, et al. 2010. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc. Natl. Acad. Sci. U. S. A. 107:1512- 1517.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 1512-1517
    • Satoh, T.1
  • 41
    • 79952844570 scopus 로고    scopus 로고
    • Identification of human parainfluenza virus type 2 (HPIV-2)Vprotein amino acid residues that reduce binding ofVto MDA5 and attenuate HPIV-2 replication in nonhuman primates
    • Schaap-Nutt A, et al. 2011. Identification of human parainfluenza virus type 2 (HPIV-2)Vprotein amino acid residues that reduce binding ofVto MDA5 and attenuate HPIV-2 replication in nonhuman primates. J. Virol. 85:4007- 4019.
    • (2011) J. Virol. , vol.85 , pp. 4007-4019
    • Schaap-Nutt, A.1
  • 42
    • 68049089651 scopus 로고    scopus 로고
    • Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
    • Schlee M, et al. 2009. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31:25-34.
    • (2009) Immunity , vol.31 , pp. 25-34
    • Schlee, M.1
  • 43
    • 78651358320 scopus 로고    scopus 로고
    • Pattern recognition of viral nucleic acids by RIG-I-like helicases
    • Schmidt A, Endres S, Rothenfusser S. 2011. Pattern recognition of viral nucleic acids by RIG-I-like helicases. J. Mol. Med. 89:5-12.
    • (2011) J. Mol. Med. , vol.89 , pp. 5-12
    • Schmidt, A.1    Endres, S.2    Rothenfusser, S.3
  • 44
    • 67749133995 scopus 로고    scopus 로고
    • 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
    • Schmidt A, et al. 2009. 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc. Natl. Acad. Sci. U. S. A. 106:12067-12072.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 12067-12072
    • Schmidt, A.1
  • 45
    • 79952591283 scopus 로고    scopus 로고
    • The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity
    • Schuhmann KM, Pfaller CK, Conzelmann KK. 2011. The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity. J. Virol. 85:3162-3171.
    • (2011) J. Virol. , vol.85 , pp. 3162-3171
    • Schuhmann, K.M.1    Pfaller, C.K.2    Conzelmann, K.K.3
  • 46
    • 18144378011 scopus 로고    scopus 로고
    • Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways
    • Shaw ML, Cardenas WB, Zamarin D, Palese P, Basler CF. 2005. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways. J. Virol. 79: 6078-6088.
    • (2005) J. Virol. , vol.79 , pp. 6078-6088
    • Shaw, M.L.1    Cardenas, W.B.2    Zamarin, D.3    Palese, P.4    Basler, C.F.5
  • 47
    • 33745839246 scopus 로고    scopus 로고
    • Sendai virus defectiveinterfering genomes and the activation of interferon-beta
    • Strahle L, Garcin D, Kolakofsky D. 2006. Sendai virus defectiveinterfering genomes and the activation of interferon-beta. Virology 351: 101-111.
    • (2006) Virology , vol.351 , pp. 101-111
    • Strahle, L.1    Garcin, D.2    Kolakofsky, D.3
  • 48
    • 36048996083 scopus 로고    scopus 로고
    • Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins
    • Strähle L, et al. 2007. Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins. J. Virol. 81:12227-12237.
    • (2007) J. Virol. , vol.81 , pp. 12227-12237
    • Strähle, L.1
  • 49
    • 67650510680 scopus 로고    scopus 로고
    • Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors
    • Takahasi K, et al. 2009. Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J. Biol. Chem. 284:17465-17474.
    • (2009) J. Biol. Chem. , vol.284 , pp. 17465-17474
    • Takahasi, K.1
  • 50
    • 33746714414 scopus 로고    scopus 로고
    • Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1
    • Van Cleve W, et al. 2006. Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1. Virology 352:61-73.
    • (2006) Virology , vol.352 , pp. 61-73
    • Van Cleve, W.1
  • 51
    • 34248168157 scopus 로고    scopus 로고
    • Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses
    • Venkataraman T, et al. 2007. Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J. Immunol. 178:6444-6455.
    • (2007) J. Immunol. , vol.178 , pp. 6444-6455
    • Venkataraman, T.1
  • 52
    • 77954386541 scopus 로고    scopus 로고
    • Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I
    • Wang Y, et al. 2010. Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat. Struct. Mol. Biol. 17:781-787.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 781-787
    • Wang, Y.1
  • 53
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber F, Wagner V, Rasmussen SB, Hartmann R, Paludan SR. 2006. Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J. Virol. 80:5059 -5064.
    • (2006) J. Virol. , vol.80 , pp. 5059-5064
    • Weber, F.1    Wagner, V.2    Rasmussen, S.B.3    Hartmann, R.4    Paludan, S.R.5
  • 54
    • 23844438864 scopus 로고    scopus 로고
    • Shared and unique functions of the DExD/Hbox helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    • Yoneyama M, et al. 2005. Shared and unique functions of the DExD/Hbox helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175:2851-2858.
    • (2005) J. Immunol. , vol.175 , pp. 2851-2858
    • Yoneyama, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.