Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse model

Transfusion

Volumn 52, Issue 6, 2012, Pages 1333-1347

  Yang, Jie ^a,b   Fan, Huahua ^a,b   Hao, Jun ^a,b   Ren, Yana ^a,b   Chen, Liang ^a,b   Li, Guiping ^a,b   Xie, Rufeng ^a,b   Yang, Yiming ^a,b   Qian, Kaicheng ^a,b   Liu, Mingyao ^a,b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b Shanghai Cord Blood Bank   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GRAFT VERSUS HOST DISEASE; ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE MARROW TRANSPLANTATION; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SURVIVAL; TH17 CELL; UMBILICAL CORD BLOOD;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD4; CELL POLARITY; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FETAL BLOOD; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; HUMANS; INFANT, NEWBORN; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84861186968     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2011.03448.x     Document Type: Article

References (62)

1. Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol 2007;7:340-52. (Pubitemid 46674485)
2. Welniak LA, Blazar BR, Murphy WJ. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu Rev Immunol 2007;25:139-70. (Pubitemid 46697905)
3. Korngold B, Sprent J. Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow. J Exp Med 1978;148:1687-98. (Pubitemid 9084041)
4. Sun Y, Tawara I, Toubai T, Reddy P. Pathophysiology of acute graft-versus-host disease: recent advances. Transl Res 2007;150:197-214. Epub 2007 Jul 3.
5. Messina C, Faraci M, de Fazio V, Dini G, Calò MP, Calore E; EBMT PaediatricWorking Party. Prevention and treatment of acute GvHD. Bone Marrow Transplant 2008;41 Suppl 2: S65-70. (Pubitemid 351864710)
6. Bleakley M, Riddell SR. Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer 2004;4:371- 80.
7. Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood 2008;112:4371-83.
8. Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 2009;30:656-65.
9. Trzonkowski P, Szarynska M, Myśliwska J, Myśliwski A. Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy. Cytometry A 2009;75:175-88.
10. Komanduri KV, Champlin RE. Can Treg therapy prevent GVHD? Blood 2011;117:751-2.
11. Jonuleit H, Tuettenberg A, Steinbrink K; Working Group Dermatologic Research (Abeitsgemeinschaft Dermatologische Forschung, ADF). Research in practice: regulatory T cells-targets for therapeutic approaches? J Dtsch Dermatol Ges 2011;9:8-11.
12. Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010;11:7-13.
13. Roncarolo MG, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007;7:585-98. (Pubitemid 47123554)
14. Langier S, Sade K, Kivity S. Regulatory T cells: the suppressor arm of the immune system. Autoimmun Rev 2010;10: 112-5.
15. high regulatory T cell function. J Immunol 2002;169:6210-7.
16. Baecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells. Semin Immunol 2004;16: 89-98.
17. Cohen JL, Boyer O. The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease. Curr Opin Immunol 2006;18:580-5. (Pubitemid 44322035)
18. Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002;99: 3493-9. (Pubitemid 34534513)
19. Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003;9:1144-50. (Pubitemid 37173698)
20. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002;196:389-99. (Pubitemid 34875667)
21. Wang S, Jiang J, Guan Q, Lan Z,Wang H, Nguan CY, Jevnikar AM, Du C. Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model. Transpl Immunol 2008;19:93-102.
22. Xia G, Shah M, Luo X. Prevention of allograft rejection by amplification of Foxp3 (+)CD4(+)CD25(+) regulatory T cells. Transl Res 2009;153:60-70.
23. Zorn E. CD4+CD25+ regulatory T cells in human hematopoietic cell transplantation. Semin Cancer Biol 2006;16: 150-9. (Pubitemid 43172063)
24. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001;182:18-32. (Pubitemid 33070205)
25. Sugimoto N, Oida T, Hirota K, Nakamura K, Nomura T, Uchiyama T, Sakaguchi S. Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol 2006;18:1197-209. (Pubitemid 44349295)
26. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11. (Pubitemid 44036276)
27. Duggleby RC, Shaw TN, Jarvis LB, Kaur G, Gaston JS. CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells. Immunology 2007;121:129-39. (Pubitemid 46537672)
28. Wing K, Ekmark A, Karlsson H, Rudin A, Suri-Payer E. Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood. Immunology 2002;106:190-9. (Pubitemid 34621827)
29. Hao L, Gao L, Chen XH, Zou ZM, Zhang X, Kong PY, Zhang C, Peng XG, Sun AH, Wang QY. Human umbilical cord blood-derived stromal cells prevent graft-versus-host disease in mice following haplo-identical stem cell transplantation. Cytotherapy 2011;13:83-91.
30. Tolar J, Hippen KL, Blazar BR. Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells. Br J Haematol 2009;147:200-6.
31. Hutton JF, Gargett T, Sadlon TJ, Bresatz S, Brown CY, Zola H, Shannon MF, D'Andrea RJ, Barry SC. Development of CD4+CD25+FoxP3+ regulatory T cells from cord blood hematopoietic progenitor cells. J Leukoc Biol 2009;85:445-51.
32. Bresatz S, Sadlon T, Millard D, Zola H, Barry SC. Isolation, propagation and characterization of cord blood derived CD4+ CD25+ regulatory T cells. J Immunol Methods 2007;327:53-62. (Pubitemid 47444305)
33. Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB. Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 2005;105:750-8. (Pubitemid 40070762)
34. Lee CC, Lin SJ, Cheng PJ, Kuo ML. The regulatory function of umbilical cord blood CD4(+) CD25(+) T cells stimulated with anti-CD3/anti-CD28 and exogenous interleukin (IL)-2 or IL-15. Pediatr Allergy Immunol 2009;20:624-32.
35. Asanuma S, Tanaka J, Sugita J, Kosugi M, Shiratori S, Wakasa K, Shono Y, Shigematsu A, Kondo T, Kobayashi T, Asaka M, Imamura M. Expansion of CD4(+)CD25 (+) regulatory T cells from cord blood CD4(+) cells using the common g-chain cytokines (IL-2 and IL-15) and rapamycin. Ann Hematol 2010;90:617-24.
36. Brunstein C, Hippen KL, McKenna DH, Cao Q, Curtsinger J, Sumstad D, Levine BL, Riley JL, June CH, Miller JS, Blazar BR, Wagner JE. Adoptive transfer of umbilical cord blood (UCB)-derived regulatory T cells (Tregs) to recipients of nonmyeloablative unrelated double UCB transplantation. Blood (ASH Annual Meeting Abstracts) 2009;114:513.
37. Verneris MR, Brunstein CG, Barker J, MacMillan ML, DeFor T, McKenna DH, Burke MJ, Blazar BR, Miller JS, McGlave PB, Weisdorf DJ, Wagner JE. Relapse risk after umbilical cord blood transplantation: enhanced graft-versusleukemia effect in recipients of 2 units. Blood 2009;114:4293-9.
38. Yang J, Gao L, Liu Y, Ren Y, Xie R, Fan H, Qian K. Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation. Transfusion 2010;50:407-17.
39. Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target antigens determine graftversus- host disease phenotype. J Immunol 2004;173:5467-75. (Pubitemid 39392131)
40. Fritzsching E, Kunz P, Maurer B, Pöschl J, Fritzsching B. Regulatory T cells and tolerance induction. Clin Transplant 2009;23 Suppl 21:10-4.
41. Jiang S, Tsang J, Tam P. Regulatory T cell immunotherapy for transplantation tolerance: step into clinic. Int Immunopharmacol 2010;10:1486-90.
42. Joffre O, van Meerwijk JP. CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation. Semin Immunol 2006;18:128-35. (Pubitemid 43248741)
43. Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, Defor T, Levine BL, June CH, Rubinstein P, McGlave PB, Blazar BR, Wagner JE. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011;117:1061-70.
44. Escalon MP, Komanduri KV. Cord blood transplantation: evolving strategies to improve engraftment and immune reconstitution. Curr Opin Oncol 2010;22:122-9.
45. Hippen KL, Harker-Murray P, Porter SB, Merkel SC, Londer A, Taylor DK, Bina M, Panoskaltsis-Mortari A, Rubinstein P, Van Rooijen N, Golovina TN, Suhoski MM, Miller JS, Wagner JE, June CH, Riley JL, Blazar BR. Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. Blood 2008;112:2847-57.
46. Tran DQ, Shevach EM. Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells. Hum Immunol 2009;70:294-9.
47. Chen XJ, Jensen PE. Cutting edge: primary B lymphocytes preferentially expand allogeneic FoxP3+ CD4 T cells. J Immunol 2007;179:2046-50.
48. Golovina TN, Mikheeva T, Suhoski MM, Aqui NA, Tai VC, Shan X, Liu R, Balcarcel RR, Fisher N, Levine BL, Carroll RG, Warner N, Blazar BR, June CH, Riley JL. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008;181:2855-68.
49. Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 2008;111:453-62.
50. high regulatory T cells. Blood 2004;104: 895-903.
51. Earle KE, Tang Q, Zhou X, Liu W, Zhu S, Bonyhadi ML, Bluestone JA. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 2005;115:3-9. (Pubitemid 40616162)
52. Liu J, Lluis A, Illi S, Layland L, Olek S, vonMutius E, Schaub B. T regulatory cells in cord blood-FOXP3 demethylation as reliable quantitative marker. PLoS ONE 2010;5:e13267.
53. Salcido-Ochoa F, Tsang J, Tam P, Falk K, Rotzschke O. Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role? Transplant Rev (Orlando) 2010;24:52-66.
54. Mandapathil M, Lang S, Gorelik E, Whiteside TL. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J Immunol Methods 2009;346:55-63.
55. Corthay A. How do regulatory T cells work? Scand J Immunol 2009;70:326-36.
56. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008;8:523-32.
57. Kim YJ, Broxmeyer HE. Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance. Crit Rev Oncol Hematol 2011;79:112-26.
58. Cao T, Soto A, Zhou W, Wang W, Eck S, Walker M, Harriman G, Li L. Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD). Cell Immunol 2009;258:65-71.
59. Trenado A, Sudres M, Tang Q, Maury S, Charlotte F, Grégoire S, Bonyhadi M, Klatzmann D, Salomon BL, Cohen JL. Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J Immunol 2006;176:1266-73. (Pubitemid 43099732)
60. Chang CC, Satwani P, Oberfield N, Vlad G, Simpson LL, Cairo MS. Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naive and antigenic-specific cord blood Treg cells. Exp Hematol 2005;33:1508-20. (Pubitemid 41773851)
61. Steiner D, Brunicki N, Blazar BR, Bachar-Lustig E, Reisner Y. Tolerance induction by third-party "off-the-shelf"CD4+CD25+ Treg cells. Exp Hematol 2006;34:66-71. (Pubitemid 43069602)
62. Chen WJ, Konkel JE. TGF-β and "Adaptive" Foxp3+regulatory T cells. J Mol Cell Biol 2010;2:30-6.