Research in practice: Regulatory T cells - Targets for therapeutic approaches?;Forschen für die Praxis: Regulatorische T-Zellen - Therapeutische Zielzellen?

JDDG - Journal of the German Society of Dermatology

Volumn 9, Issue 1, 2011, Pages 8-11

  Jonuleit, Helmut ^a   Tuettenberg, Andrea ^a   Steinbrink, Kerstin ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

allergies; autoimmunity; cancer; regulatory T cells; signal transduction; tolerance

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 2;

ADOPTIVE TRANSFER; ALLERGY; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CANCER STAGING; CD4+ CD25+ T LYMPHOCYTE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL FUNCTION; CELL POPULATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INFECTION; LYMPHOCYTE DIFFERENTIATION; MEDICAL RESEARCH; MELANOMA; NEOPLASM; OCCUPATIONAL DISEASE; PATIENT SATISFACTION; PREVALENCE; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SKIN ALLERGY; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; CYTOKINES; HUMANS; IMMUNE SYSTEM DISEASES; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES, REGULATORY;

EID: 78650958711     PISSN: 16100379     EISSN: 16100387     Source Type: Journal    
DOI: 10.1111/j.1610-0387.2010.07503.x     Document Type: Article

References (22)

1. Wing K, Sakaguchi, S,. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010; 11: 7-13.
2. Josefowics SZ, Rudensky A,. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009; 30: 616-25.
3. Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD,. Nat Genet 2001; 27: 20-1.
4. Roncarolo MG, Gregori S, Battaglia M, Bachetta R, Fleischhauer K, Levings MK,. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006; 212: 28-50.
5. + Treg-mediated suppression. Trends Immunol 2008; 29: 337-42.
6. + T helper type 2 cells. J Exp Med 1996; 183: 759-68. (Pubitemid 26113948)
7. Maurer M, Seidel-Guyenot W, Metz M, Knop J, Steinbrink K,. Critical role of IL-10 in the induction of low zone tolerance to contact allergens. J Clin Invest 2003; 112: 432-9.
8. Seidel-Guyenot W, Alt R, Perschon S, Knop J, Steinbrink K,. B cells are not required for T cell priming in low zone tolerance to contact allergens and contact hypersensitivity. Eur J Immunol 2004; 34: 3082-90.
9. Seidel-Guyenot W, Perschon S, Dechant N, Alt R, Steinbrink K,. Low zone tolerance induced by systemic application of allergens inhibits Tc1-mediated skin inflammation. J Allergy Clin Immunol 2007; 117: 1170-7.
10. + T cells resulting in a failure to lyse tumor cells. Blood 1999; 5: 1634-42.
11. Correll A, Tuettenberg A, Becker C, Jonuleit H,. Increased regulatory T-cell frequencies in patients with advanced melanoma correlate with a generally impaired T-cell responsiveness and are restored after dendritic cell-based vaccination. Experimental Dermatology, 2010; 19: e213-21.
12. Jonuleit H, Giesecke-Tuettenberg A, Tueting T, Thurner-Schuler B, Stuge TB, Paragnik L, Kandemir A, Lee PP, Schuler G, Knop J, Enk AH,. A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection. Int J Cancer 2001; 93: 243-51.
13. Tuettenberg A, Becker C, Huter E, Knop J, Enk A, Jonuleit H,. Strong, persistent Melan-A/MART-1-peptide-specific immune responses after dendritic cell vaccination of tumor-free stage II melanoma patients. Int J Cancer 2006; 118: 2617-27.
14. + T cells with regulatory poperties by repetitive stimulation iwth allogeneic immature human dendritic cells. J Exp Med 2000; 192: 1213-22.
15. Steinbrink K, Woelfl M, Jonuleit H, Knop J, Enk AH,. Induction of tolerance by interleukin-10-treated dendritic cells. J Immunol 1997; 159: 4772-80. (Pubitemid 127471012)
16. 8 anergic T cells induced by IL-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 2002; 99: 2468-76.
17. Bellinghausen I, Brand U, Steinbrink K, Enk AH, Knop J, Saloga J,. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol 2001; 108: 242-9.
18. Adler H, Simon A, Graulich E, Habermeier A, Bacher N, Friebe A, Closs EI, Steinbrink K,. Neuronal nitric oxide synthase modulates maturation of human dendritic cells. J Immunol 2010; 184: 6025-34.
19. Tuettenberg A, Huter E, Hubo M, Horn J, Knop J, Grimbacher B, Kroczek R, Stoll S, Jonuleit H,. The role of ICOS in directing T cell responses: ICOS dependent induction of T cell anergy by tolerogenic dendritic cells. J Immunol 2009; 182: 3349-56.
20. Tuettenberg A, Fondel S, Steinbrink K, Enk AH, Jonuleit H,. CD40 signalling induces IL-10-producing, tolerogenic dendritic cells. Exp Dermatol 2010; 19: 44-53.
21. Kip1. Eur J Immunol 2003; 33: 1988-97.
22. Adler H, Kubsch S, Graulich E, Ludwig S, Knop J, Steinbrink K,. Activation of MAP kinase p38 is critical for the regulatory function of anergic T cells induced by tolerogenic dendritic cells. Blood 2007; 109: 4351-9.