Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model

Transplant Immunology

Volumn 19, Issue 2, 2008, Pages 93-102

  Wang, Shuang ^a   Jiang, Jifu ^a   Guan, Qiunong ^b,c   Lan, Zhu ^a   Wang, Hao ^a   Nguan, Christopher Y C ^c   Jevnikar, Anthony M ^a,b   Du, Caigan ^a,b,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Interleukin 6; Kidney transplantation; Treg cells

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; IN VITRO STUDY; KIDNEY DONOR; KIDNEY GRAFT REJECTION; KIDNEY TUBULE EPITHELIUM; LYMPHOCYTIC INFILTRATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PHENOTYPE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; UPREGULATION;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKIN-6; KIDNEY; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 43949105490     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2008.03.004     Document Type: Article

References (55)

1. - regulatory cells mediate dominant transplantation tolerance. J Immunol 168 11 (2002) 5558-5565
2. Hall B.M. Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell. J Exp Med 161 1 (1985) 123-133
3. Mottram P.L., Mirisklavos A., Dumble L.J., and Clunie G.J. T suppressor cells induced by transfusions and cyclosporine: studies in the murine cardiac allograft model. Transplantation 50 6 (1990) 1033-1037
4. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 168 3 (2002) 1080-1086
5. + regulatory T cells. J Immunol 174 11 (2005) 6993-7005
6. Kitade H., Kawai M., Rutgeerts O., Landuyt W., Waer M., Mathieu C., and Pirenne J. Early presence of regulatory cells in transplanted rats rendered tolerant by donor-specific blood transfusion. J Immunol 175 8 (2005) 4963-4970
7. Hoglund P. Induced peripheral regulatory T cells: the family grows larger. Eur J Immunol 36 2 (2006) 264-266
8. Thornton A.M. T regulatory cells. Curr Biol 15 15 (2005) R582
9. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 179 2 (1994) 589-600
10. Shevach E.M. Regulatory T cells in autoimmmunity. Annu Rev Immunol 18 (2000) 423-449
11. Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., and Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265 5176 (1994) 1237-1240
12. Thomson C.W., Lee B.P., and Zhang L. Double-negative regulatory T cells: non-conventional regulators. Immunol Res 35 1-2 (2006) 163-178
13. Maloy K.J., and Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2 9 (2001) 816-822
14. + T cells: multiple pathways on the road. J Cell Physiol 211 3 (2007) 590-597
15. + regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen. J Immunol 174 6 (2005) 3290-3297
16. + regulatory T cells in the induction and maintenance of transplantation tolerance. Transpl Immunol 17 2 (2007) 20-129
17. Campbell D.J., and Ziegler S.F. FOXP3 modifies the phenotypic and functional properties of regulatory T cells. Nat Rev Immunol 7 4 (2007) 305-310
18. Yates P.J., and Nicholson M.L. The aetiology and pathogenesis of chronic allograft nephropathy. Transpl Immunol 16 3-4 (2006) 148-157
19. + cells in renal allografts during acute rejection. Am J Transplant 7 4 (2007) 914-922
20. Grimbert P., Mansour H., Desvaux D., Roudot-Thoraval F., Audard V., Dahan K., et al. The regulatory/cytotoxic graft-infiltrating T cells differentiate renal allograft borderline change from acute rejection. Transplantation 83 3 (2007) 341-346
21. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 7090 (2006) 235-238
22. Jevnikar A.M., Brennan D.C., Singer G.G., Heng J.E., Maslinski W., Wuthrich R.P., et al. Stimulated kidney tubular epithelial cells express membrane associated and secreted TNF alpha. Kidney Int 40 2 (1991) 203-211
23. Du C., Jiang J., Guan Q., Yin Z., Masterson M., Parbtani A., et al. Renal tubular epithelial cell self-injury through Fas/Fas ligand interaction promotes renal allograft injury. Am J Transplant 4 10 (2004) 1583-1594
24. Kruger T., Benke D., Eitner F., Lang A., Wirtz M., Hamilton-Williams E.E., et al. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 15 3 (2004) 613-621
25. Schnickel G.T., Whiting D., Hsieh G.R., Yun J.J., Fischbein M.P., Fishbein M.C., et al. CD8 lymphocytes are sufficient for the development of chronic rejection. Transplantation 78 11 (2004) 1634-1639
26. Fossiez F., Banchereau J., Murray R., Van Kooten C., Garrone P., and Lebecque S. Interleukin-17. Int Rev Immunol 16 5-6 (1998) 541-551
27. + regulatory T-cell therapy for allergy, autoimmune disease and transplant rejection. Inflamm Allergy Drug Targets 5 4 (2006) 239-242
28. Russell P.S., Chase C.M., Colvin R.B., and Plate J.M. Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants. J Exp Med 147 5 (1978) 1449-1468
29. Coffman T., Geier S., Ibrahim S., Griffiths R., Spurney R., Smithies O., et al. Improved renal function in mouse kidney allografts lacking MHC class I antigens. J Immunol 151 1 (1993) 425-435
30. Bickerstaff A.A., Wang J.J., Pelletier R.P., and Orosz C.G. Murine renal allografts: spontaneous acceptance is associated with regulated T cell-mediated immunity. J Immunol 167 9 (2001) 4821-4827
31. Wang S., Guan Q., Diao H., Lian D., Zhong R., Jevnikar A.M., and Du C. Prolongation of Cardiac allograft survival by inhibition of ERK1/2 signaling in a mouse model. Transplantation 83 3 (2007) 323-332
32. Wang S., Diao H., Guan Q., Jevnikar A.M., and Du C. Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model. Transpl Immunol 18 1 (2007) 53-61
33. + regulatory T cells. Transplantation 82 12 (2006) 1749-1755
34. + T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J Immunol 169 10 (2002) 5401-5404
35. + T cells. Proc Natl Acad Sci U S A 101 27 (2004) 10122-10126
36. Emara M.A., and Mozes M.F. Cytotoxic T-cell role in renal allograft rejection and regulation. Renal allograft infiltrating cytotoxic T-cell line with suppressor-inducer function. Hum Immunol 42 2 (1995) 161-173
37. Totterman T.H., Hanas E., Larsson E., Sjoberg O., and Tufveson G. Regulation of human allograft rejection: kidney-infiltrating suppressor inducer and suppressor effector T-cells are reduced during rejection. Transplant Proc 21 1 pt 1 (1989) 359-360
38. - cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 172 9 (2004) 5213-5221
39. + regulatory T cells. Proc Natl Acad Sci U S A 104 8 (2007) 2821-2826
40. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198 12 (2003) 1875-1886
41. - precursors. Am J Transplant 4 10 (2004) 1614-1627
42. - T cells. Int Immunol 16 8 (2004) 1203-1213
43. + T cells. J Immunol 173 11 (2004) 6526-6531
44. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 2 (2006) 179-189
45. Raasveld M.H., Weening J.J., Kerst J.M., Surachno S., and ten Berge R.J. Local production of interleukin-6 during acute rejection in human renal allografts. Nephrol Dial Transplant 8 1 (1993) 75-78
46. Di Paolo S., Gesualdo L., Stallone G., Ranieri E., and Schena F.P. Renal expression and urinary concentration of EGF and IL-6 in acutely dysfunctioning kidney transplanted patients. Nephrol Dial Transplant 12 12 (1997) 2687-2693
47. Waiser J., Budde K., Katalinic A., Kuerzdorfer M., Riess R., and Neumayer H.H. Interleukin-6 expression after renal transplantation. Nephrol Dial Transplant 12 4 (1997) 753-759
48. Malan Borel I., Racca A., Garcia M.I., Bailat A., Quiroga F., Soutullo A., and Gaite L. Gammadelta T cells and interleukin-6 levels could provide information regarding the progression of human renal allograft. Scand J Immunol 58 1 (2003) 99-105
49. Merville P., Pouteil-Noble C., Wijdenes J., Potaux L., Touraine J.L., and Banchereau J. Detection of single cells secreting IFN-gamma, IL-6, and IL-10 in irreversibly rejected human kidney allografts, and their modulation by IL-2 and IL-4. Transplantation 55 3 (1993) 639-646
50. Van Kooten C., Boonstra J.G., Paape M.E., Fossiez F., Banchereau J., Lebecque S., et al. Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J Am Soc Nephrol 9 8 (1998) 1526-1534
51. Loong C.C., Hsieh H.G., Lui W.Y., Chen A., and Lin C.Y. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 197 3 (2002) 322-332
52. + tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol 16 (2004) 1055-1068
53. + regulatory T cells by continuous antigen stimulation. Eur J Immunol 38 3 (2008) 640-646
54. + T cells activated in the presence of TGF beta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 18 11 (2006) 1549-1562
55. + T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol 13 4 (2004) 239-247