Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: A novel potent blocker of Kv1.3 potassium channels of human T lymphocytes

Biochemistry

Volumn 51, Issue 19, 2012, Pages 4049-4061

  Gurrola, Georgina B ^a   Hernández López, Rogelio A ^b   Rodríguez De La Vega, Ricardo C ^c,e   Varga, Zoltan ^d   Batista, Cesar V F ^a   Salas Castillo, Saida P ^a   Panyi, Gyorgy ^d   Del Río Portilla, Federico ^b   Possani, Lourival D ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITY OF DEBRECEN   (Hungary)

^e CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL BLOCKERS; CHEMICAL SYNTHESIS; DISULFIDE BRIDGE; HUMAN LYMPHOCYTES; HUMAN T LYMPHOCYTES; ION CHANNEL; POTASSIUM CHANNELS; PROTEOMIC ANALYSIS; SEQUENCE ANALYSIS; STRUCTURAL FEATURE; THREE-DIMENSIONAL SOLUTIONS;

COVALENT BONDS;

PEPTIDES;

POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEOMICS; SCORPION; VAEJOVIS MEXICANUS;

AMINO ACID MOTIFS; ANIMALS; DISULFIDES; DRUG EVALUATION, PRECLINICAL; HUMANS; KV1.3 POTASSIUM CHANNEL; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; PEPTIDES; PHYLOGENY; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; SCORPION VENOMS; SCORPIONS; T-LYMPHOCYTES;

ANIMALIA; SCORPIONES; VAEJOVIS;

EID: 84861164829     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300060n     Document Type: Article

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