The possibility of simvastatin as a chemotherapeutic agent for all-trans retinoic acid-resistant promyelocytic leukemia

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 3, 2008, Pages 369-374

  Tomiyama, Naoki ^a   Matzno, Sumio ^a   Kitada, Chihiro ^a   Nishiguchi, Eri ^a   Okamura, Noboru ^a   Matsuyama, Kenji ^b  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

All trans retinoic acid resistant acute promyelocytic leukemia; Apoptosis; Statin

Indexed keywords

ATORVASTATIN; CASPASE 9; CERIVASTATIN; CYTOCHROME C; FLUINDOSTATIN; GUANOSINE TRIPHOSPHATASE; ISOPRENOID; REACTIVE OXYGEN METABOLITE; RETINOIC ACID; SIMVASTATIN;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROMYELOCYTIC LEUKEMIA; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 9; CELL SURVIVAL; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, AGAR GEL; HL-60 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIMVASTATIN; TRETINOIN;

EID: 41149118896     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.369     Document Type: Article

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