Erratum: Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases (European Journal of Immunology (2006) vol. 36 (11) 10.1002/eji.200636567));Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases

European Journal of Immunology

Volumn 36, Issue 11, 2006, Pages 2885-2893

  Ghittoni, Raffaela ^a   Napolitani, Giorgio ^b   Benati, Daniela ^a   Uliveri, Cristina ^a   Patrussi, Laura ^a   Laghi Pasini, Franco ^a   Lanzavecchia, Antonio ^b   Baldari, Cosima T ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Antigen presentation processing; Dendritic cells; Lipid rafts; Prenylation; Small GTPases

Indexed keywords

HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAB PROTEIN; RAS PROTEIN; RHO GUANOSINE TRIPHOSPHATASE; SIMVASTATIN; TETANUS TOXOID;

ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; ENDOCYTOSIS; HUMAN; HUMAN CELL; LIPID RAFT; PINOCYTOSIS; PRENYLATION; PRIORITY JOURNAL; PROTEIN TRANSPORT;

EID: 33751246181     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636567     Document Type: Erratum

References (48)

1. Corsini, A., Maggi, F. M. and Catapano, A. L, Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res 1995. 31: 9-27
2. Goldstein, J. L. and Brown, M. S., Regulation of the mevalonate pathway. Nature 1990. 343: 425-430.
3. Zhang, F. L. and Casey, P. J., Protein prenylation: Molecular mechanisms and functional consequences. Annu. Rev. Biochem. 1996. 65: 241-269.
4. He, H. T., Lellouch, A. and Marguet, D., Lipid rafts and the initiation of T cell receptor signaling. Semin. Immunol. 2005. 17: 23-33.
5. Brown, D. A. and London, E., Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 2000. 275: 17221-17224.
6. Macara, I. G., Lounsbury, K. M., Richards, S. A., McKiernan, C. and Bar-Sagi D., The Ras superfamily of GTPases. FASEB J 1996. 10: 625-630.
7. Van Aelst, L and D'Souza-Schorey, C., Rho GTPases and signaling networks. Genes Dev. 1997. 11: 2295-2322.
8. Somsel Rodman, J. and Wandinger-Ness, A., Rab GTPases coordinate endocytosis. J. Cell Sci. 2000. 113: 183-192.
9. Blanco-Colio, L. M., Tunon, J., Martin-Ventura, J. L. and Egido, J., Anti-inflammatory and immunomodulatory effects of statins. Kidney Int. 2003. 63: 12-23.
10. Greenwood, J., Steinman, L and Zamvil, S. S., Statin therapy and autoimmune disease: From protein prenylation to immunomodulation. Nat. Rev. Immunol. 2006. 6: 358-370.
11. Laufs, U. and Liao, J. K., Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J. Biol. Chem. 1998. 273: 24266-24271.
12. Laufs, U., La Fata, V., Plutzky, J. and Liao, J. K., Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998. 97. 1129-1135.
13. Weitz-Schmidt G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S. et al., Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med. 2001. 7: 687-692.
14. Fehr, T., Kahlert, C., Fierz, W., Joller-Jemelka, H. I., Riesen, W. F., Rickli, H., Wuthrich, R. P. and Ammann, P., Statin-induced immunomodulatory effects on human T cells in vivo. Atherosclerosis 2004. 175: 83-90.
15. McKay, A., Leung, B. P., McInnes, I. B., Thomson, N. C. and Liew, F. Y., A novel anti-inflammatory role of sirmvastatin in a murine model of allergic asthma. J. Immunol. 2004. 172: 2903-2908.
16. Ghittoni, R., Patrussi, L., Pirozzi, K., Pellegrini, M., Lazzerini, P. E., Capecchi, P. L., Laghi Pasini, F. and Baldari, C. T., Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J 2005. 19: 605-607
17. Youssef, S., Stuve, O., Patarroyo, J. C., Ruiz, P. J., Radosevich, J. L., Hur, E. M., Bravo, M. et al., The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002. 420: 78-84.
18. Dunn, S. E., Youssef, S., Goldstein, M. J., Prod'homme, T., Weber, M. S., Zamvil, S. S. and Steinman, L., Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J. Exp. Med. 2006. 203: 401-412.
19. Kwak, B., Mulhaupt, F., Myit, S. and Mach, F., Statins as a newly recognized type of immunomodulator. Nat. Med 2000. 6: 1399-1402.
20. Yilmaz, A., Reiss, C., Tantawi, O., Weng, A., Stumpf, C., Raaz, D., Ludwig, J. et al., HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: New implications for atherosclerosis. Atherosclerosis 2004. 172: 85-93.
21. Anderson, H. A., Hiltbold, E. M. and Roche, P. A., Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 2000. 1: 156-162.
22. Stoddart, A., Dykstra, M. L, Brown, B. K., Song, W., Pierce, S. K. and Brodsky, F. M., Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity 2002. 17: 451-462.
23. Lazzarino, D. A., Blier, P. and Mellman, L, The monomeric guanosine triphosphatase Rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cells. J. Exp. Med. 1998. 188: 1769-1767.
24. Veira, O. V., Bucci, C., Harrison, R. E., Trimble, W. S., Lanzetti, L., Gruenberg, J., Schreiber, A. D. et al., Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol. Cell. Biol. 2003. 23: 2501-2514.
25. Bertram, E. M., Hawley, R. G. and Watts, T. H., Overexpression of Rab7 enhances the kinetics of antigen processing and presentation with MHC class II molecules in B cells. Int. Immunol. 2002. 14: 309-318.
26. Briken, V., Lankar, D. and Bonnerot, C., New evidence for two MHC class II-restricted antigen presentation pathways by overexpression of a small G protein. J. Immunol. 1997. 159: 4653-4658.
27. Garrett, W. S., Chen, L. M., Kroschewski, R., Ebersold, M., Turley, S., Trombetta, S., Galan, J. E. and Mellmam, I., Developmental control of endocytosis in dendritic cells by Cdc42. Cell 2000. 102: 325-334.
28. Kobayashi, M., Azuma, E., Ido, M., Hirayama, M., Jiang, Q., Iwamoto, S., Kumamoto, T. et al., A pivotal role of Rho GTPase in the regulation of morphology and function of dendritic cells. J. Immunol. 2001. 167: 3585-3591.
29. Shurin, G. V., Tourkova, I. L., Chatta, G. S., Schmidt, G., Wei, S., Djeu, J. Y. and Shurin, M. R., Small Rho GTPases regulate antigen presentation in dendritic cells. J. Immunol. 2005. 174: 3394-3400.
30. Kerksiek, K. M., Niedergang, F., Chavrier, P., Busch, D. H. and Brocker, T., Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood 2005. 105: 742-749.
31. Casey, P. J. and Seabra, M. C., Protein prenyltransferases. J. Biol. Chem. 1996. 271: 5289-5292.
32. Pieters, J., MHC class II-restricted antigen processing and presentation. Adv. Immunol. 2000. 75: 159-208.
33. Hiltbold, E. M. and Roche, P. A., Trafficking of MHC class II molecules in the late secretory pathway. Curr. Opin. Immunol. 2002. 14: 30-35.
34. Watts, C., Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 1997 15: 821-850.
35. Cella, M., Engering, A., Pinet, V., Pleters, J. and Lanzavecchia, A., Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 1997. 398: 782-787.
36. Essig, M., Nguyen, G., Prie, D., Escoubet, B., Sraer, J. D. and Friedlander, G., 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins. Circ. Res. 1998. 83: 683-690.
37. Ortego, M., Bustos, C., Hernandez-Presa, M. A., Tunon, J., Diaz, C., Hernandez, G. and Egido, J., Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells. Atherosclerosis 1999. 147: 253-261.
38. Hausding, M., Witteck, A., Rodriguez-Pascual, F., von Eichel-Streiber, C., Forstermann, U. and Kleinert, H., Inhibition of small G proteins of the Rho family by statin or Clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. J. Pharmacol. 2000. 131: 553-561.
39. Danesh, F. R., Sadeghi, M. M., Amro, N., Philips, C., Zeng, L, Lin, S., Sahai, A. and Kanwar, Y. S., 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy. Proc. Natl. Acad. Sci. USA 2002. 99: 8301-8305.
40. Eto, M., Kozai, T., Cosentino, F., Joch, H. and Luscher, T. F., Statin prevents tissue factor expression in human endothelial cells: Role of Rho/ Rho-kinase and Akt pathways. Circulation 2002. 105: 1756-1759.
41. Masamura, K., Oida, K., Kanehara, H., Suzuki, J., Horie, S., Ishit H. and Miyamori I., Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. Arterioscler. Thromb. Vasc. Biol. 2003. 23: 512-517.
42. + T lymphocytes. J. Clin. Invest. 2003. 111: 1133-1145.
43. Pfeffer, S. and Aivazian, D., Targeting Rab GTPases to distinct membrane compartments. Nat. Rev. Mol. Cell. Biol. 2004. 5: 886-896.
44. Ullrich, O., Reinsch, S., Urbe, S., Zerial, M. and Parton, R. G., Rab11 regulates recycling through the pericentriolar recycling endosome. J. Cell Biol. 1996. 135: 913-924.
45. Geuze, H. J., The role of endosomes and lysosomes in MHC class II functioning. Immunol. Today 1998. 19: 282-287.
46. Lanzavecchia, A., Antigen-specific interaction between T and B cells. Nature 1985. 314: 537-539.
47. Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Down-regulation by cytokines and bacterial products. J. Exp. Med. 1995. 182: 389-400.
48. Plyte, S., Majolini, M. B., Pacini, S., Scarpini, F., Bianchini, C., Lanfrancone, L., Pelicci, P. G. and Baldari, C.T., Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts. Oncogene 2000. 19: 1529-1537.