Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia

Leukemia and Lymphoma

Volumn 40, Issue 5-6, 2001, Pages 659-662

  Minden, M D ^a   Dimitroulakos, J ^a   Nohynek, D ^a   Penn, L Z ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

AML; Case report; Lovastatin

Indexed keywords

CHOLESTEROL; COTRIMOXAZOLE; CYTARABINE; DAUNORUBICIN; HEMOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYUREA; MEVINOLIN; RETINOIC ACID;

ACUTE MYELOBLASTIC LEUKEMIA; AGED; APOPTOSIS; ARTICLE; BLAST CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CASE REPORT; CELL GROWTH; CLINICAL EXAMINATION; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; ELDERLY CARE; FEMALE; GROWTH REGULATION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SIDE EFFECT; SKIN ULCER;

EID: 0035048749     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190109097663     Document Type: Article

References (8)

1. Adult acute leukemia
2. Regulation of the mevalonate pathway
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4. Pharmacology of competitive inhibitors of HMG-CoA reductase
5. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P-glyco-protein-expressing cells
6. Lovastatin induces a pronounced differentiation response in acute myeloid leukemias
7. Phase 1 study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
8. A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, lovastatin, and prevastatin on leukaemic and normal bone marrow progenitors