Effect of simvastatin alone and in combination with cytosine arabinoside on the proliferation of myeloid leukemia cell lines

Journal of Investigative Medicine

Volumn 49, Issue 4, 2001, Pages 319-324

  Lishner, M ^a   Bar Sef, A ^a   Elis, A ^a   Fabian, I ^a  

^a MEIR MEDICAL CENTER   (Israel)

Author keywords

AML; ARA C; Simvastatin

Indexed keywords

ANTINEOPLASTIC AGENT; CYTARABINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN; THYMIDINE; TRITIUM;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CLONOGENIC ASSAY; DRUG EFFECT; DRUG POTENTIATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MYELOID LEUKEMIA;

ARA; TRITIUM;

EID: 0034773582     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2001.33896     Document Type: Article

References (28)

1. Regulation of mevalonate pathway
2. Multivalent control of HMG-CoA reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme
3. Isoprenoid synthesis during the cell cycle
4. Post translational modification of low molecular mass GPT-binding proteins by isoprenoid
5. Evidence for modification of Lamin B by a product of mevalonic acid
6. Low density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells
7. The dual role of mevalonate in the cell cycle
8. Playing tag with membrane proteins
9. Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and Swiss 3T3 growth factor
10. Inhibition of hepatoma tissue culture growth by lovastatin: A novel chemotherapeutic strategy
11. Cell cycle specific effects of lovastatin
12. Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate. Relation of neuritic outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis
13. Selective inhibition of primary acute myeloid leukemia cell growth by simvastatin
14. Inhibitory effect of simvastatin on the proliferation of human myeloid leukemia cells in severe combined immunodeficient (SCID) mice
15. Comparison of dexamethazone and lovastatin (mevinolin) as growth inhibitors in cultures of T-cell derived human acute leukemia lines (CEM)
16. Sensitivity of hematopoietic progenitors of acute myeloblastic leukemia to new compounds derived from marine organisms
17. Mechanism of cytosine arabinoside toxicity to the blast cells of acute myeloblastic leukemia
18. Cholesterol inhibition, cancer, and chemotherapy
19. All ras proteins are polyisoprenylated but only some are palmitoylated
20. Common modifications of trimeric G proteins and ras protein: Involvement of polyisoprenylation
21. Reversal of transformed phenotype by monoclonal antibodies against Ha-ras P21 proteins
22. Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines
23. The effect of lovastatin as an adjuvant to mitomycin C on HPC-4 cell growth
24. An inhibitor of cholesterol biosynthesis, shows a synergistic effect with N, N'-Bis (2-chloroethyl)-N-Nitrosurea and β-interferon on human glioma cells
25. Effect of pravastatin, a potent 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on survival of AH 30 hepatoma bearing rats
26. Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis
27. Lovastatin, a cholesterol biosynthetic inhibitor, inhibits the growth of human H-ras transformed cells in nude mice
28. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer