Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11314-11327

  Mandal, Chandi Charan ^a   Ghosh Choudhury, Nayana ^a   Yoneda, Toshi ^a,c   Choudhury, Goutam Ghosh ^a,b   Ghosh Choudhury, Nandini ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; BREAST CANCER CELLS; BREAST TUMOR; BREAST TUMOR CELLS; CANCER STEM CELLS; CLINICAL TRIAL; DOWN-REGULATION; EPIDEMIOLOGICAL STUDIES; INVERSE CORRELATION; LOVASTATIN; MAMMARY CANCER; MAMMARY CARCINOMA; MOUSE MODELS; OSTEOLYSIS; SIMVASTATIN; STATINS; TRANSCRIPTIONAL MECHANISMS; TUMOR CELLS;

BONE; DISEASES; PATHOLOGY; STEM CELLS; TRANSCRIPTION FACTORS; TUMORS;

CELL CULTURE;

HERMES ANTIGEN; MEVINOLIN; PROTEIN P53; SHORT HAIRPIN RNA; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CANCER PREVENTION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS INHIBITION; METASTASIS POTENTIAL; MOUSE; MUTANT; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

AMINO ACID SUBSTITUTION; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; MUTATION, MISSENSE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; OSTEOLYSIS; SIMVASTATIN; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 79953217743     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.193714     Document Type: Article

References (82)

1. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
2. Demierre, M. F., Higgins, P. D., Gruber, S. B., Hawk, E., and Lippman, S. M. (2005) Nat. Rev. Cancer 5, 930-942
3. Chan, K. K., Oza, A. M., and Siu, L. L. (2003) Clin. Cancer Res. 9, 10-19
4. Graaf, M. R., Beiderbeck, A. B., Egberts, A. C., Richel, D. J., and Guchelaar, H. J. (2004) J. Clin. Oncol. 22, 2388-2394
5. Cauley, J. A., Zmuda, J. M., Lui, L.-Y., Hillier, T. A., Ness, R. B., Stone, K. L., Cummings, S. R., and Bauer, D. C. (2003) J. Womens Health 12, 749-756
6. Beck, P., Wysowski, D. K., Downey, W., and Butler-Jones, D. (2003) J. Clin. Epidemiol. 56, 280-285
7. Rao, S., Porter, D. C., Chen, X., Herliczek, T., Lowe, M., and Keyomarsi, K. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7797-7802
8. Ukomadu, C., and Dutta, A. (2003) J. Biol. Chem. 278, 43586-43594
9. Wu, J., Wong, W. W., Khosravi, F., Minden, M. D., and Penn, L. Z. (2004) Cancer Res. 64, 6461-6468
10. Ghosh-Choudhury, N., Mandal, C. C., Ghosh-Choudhury N., and Ghosh Choudhury, G. (2010) Cell. Signal. 22, 749-758
11. Sørlie, T., Perou, C. M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Thorsen, T., Quist, H., Matese, J. C., Brown, P. O., Botstein, D., Eystein Lønning, P., and Børresen-Dale, A. L. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 10869-10874
12. Ries, L. A. G., Melbert, D., Krapcho, M., Stinchcomb, D. G., Howlader, N., Horner, M. J., Mariotto, A., Miller, B. A., Feuer, E. J., Altekruse, S. F., Lewis, D. R., Clegg, L., Eisner, M. P., Reichman, M., and Edwards, B. (eds) (2005) SEER Cancer Statistics Review 1975-2005, National Cancer Institute, Bethesda, MD
13. Weinberg, R. A. (2008) Nat. Cell Biol. 10, 1021-1023
14. Gupta, G. P., Nguyen, D. X., Chiang, A. C., Bos, P. D., Kim, J. Y., Nadal, C., Gomis, R. R., Manova-Todorova, K., and Massagué, J. (2007) Nature 446, 765-770
15. Padua, D., Zhang, X. H., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., and Massagué, J. (2008) Cell 133, 66-77
16. Minn, A. J., Gupta, G. P., Padua, D., Bos, P., Nguyen, D. X., Nuyten, D., Kreike, B., Zhang, Y., Wang, Y., Ishwaran, H., Foekens, J. A., van de Vijver, M., and Massagué, J. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 6740-6745
17. Kopp, H. G., Avecilla, S. T., Hooper, A. T., and Rafii, S. (2005) Physiology 20, 349-356
18. Mundy, G. R. (2002) Nat. Rev. Cancer 2, 584-593
19. Godar, S., Ince, T. A., Bell, G. W., Feldser, D., Donaher, J. L., Bergh, J., Liu, A., Miu, K., Watnick, R. S., Reinhardt, F., McAllister, S. S., Jacks, T., and Weinberg, R. A. (2008) Cell 134, 62-73
20. Kern, S. E., Kinzler, K. W., Bruskin, A., Jarosz, D., Friedman, P., Prives, C., and Vogelstein, B. (1991) Science 252, 1708-1711
21. Hiraga, T., Williams, P. J., Mundy, G. R., and Yoneda, T. (2001) Cancer Res. 61, 4418-4424
22. Bange, J., Prechtl, D., Cheburkin, Y., Specht, K., Harbeck, N., Schmitt, M., Knyazeva, T., Müller, S., Gärtner, S., Sures, I., Wang, H., Imyanitov, E., Häring, H. U., Knayzev, P., Iacobelli, S., Höfler, H., and Ullrich, A. (2002) Cancer Res. 62, 840-847
23. Mandal, C. C., Ghosh Choudhury, G., and Ghosh-Choudhury, N. (2009) Endocrinology 150, 4989-4998
24. Ghosh-Choudhury, T., Mandal, C. C., Woodruff, K., St Clair, P., Fernandes, G., Choudhury, G. G., and Ghosh-Choudhury, N. (2009) Breast Cancer Res. Treat. 118, 213-228
25. Dey, N., Ghosh-Choudhury, N., Das, F., Li, X., Venkatesan, B., Barnes, J. L., Kasinath, B. S., and Ghosh Choudhury, G. (2010) J. Cell. Physiol. 225, 27-41
26. Ghosh-Choudhury, N., Mandal, C. C., and Choudhury, G. G. (2007) J. Biol. Chem. 282, 4983-4993
27. Ghosh-Choudhury, N., Singha, P. K., Woodruff, K., St Clair, P., Bsoul, S., Werner, S. L., and Choudhury, G. G. (2006) J. Biol. Chem. 281, 20160-20170
28. Mandal, C. C., Drissi, H., Choudhury, G. G., and Ghosh-Choudhury, N. (2010) Calcif. Tissue Int. 87, 533-540
29. Toy, E. P., Bonafé, N., Savlu, A., Zeiss, C., Zheng, W., Flick, M., and Chambers, S. K. (2005) Clin. Exp. Metastasis 22, 1-9
30. Barbour, A. P., Reeder, J. A., Walsh, M. D., Fawcett, J., Antalis, T. M., and Gotley, D. C. (2003) Cancer Res. 63, 887-892
31. Weber, G. F., Bronson, R. T., Ilagan, J., Cantor, H., Schmits, R., and Mak, T. W. (2002) Cancer Res. 62, 2281-2286
32. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., and Clarke, M. F. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3983-3988
33. Hurt, E. M., Kawasaki, B. T., Klarmann, G. J., Thomas, S. B., and Farrar, W. L. (2008) Br. J. Cancer 98, 756-765
34. Wright, M. H., Calcagno, A. M., Salcido, C. D., Carlson, M. D., Ambudkar, S. V., and Varticovski, L. (2008) Breast Cancer Res. 10, R10
35. Ouhtit, A., Abd Elmageed, Z. Y., Abdraboh, M. E., Lioe, T. F., and Raj, M. H. (2007) Am. J. Pathol. 171, 2033-2039
36. Naor, D., Wallach-Dayan, S. B., Zahalka, M. A., and Sionov, R. V. (2008) Semin. Cancer Biol. 18, 260-267
37. Evan, G. I. (2008) Cancer Cell 14, 108-110
38. Zilfou, J. T., and Lowe, S. W. (2009) Cold Spring Harb. Perspect. Biol. 1:a001883
39. O'Connor, P. M., Jackman, J., Bae, I., Myers, T. G., Fan, S., Mutoh, M., Scudiero, D. A., Monks, A., Sausville, E. A., Weinstein, J. N., Friend, S., Fornace, A. J., Jr., and Kohn, K. W. (1997) Cancer Res. 57, 4285-4300
40. Weber, G. F. (2008) Cancer Lett. 270, 181-190
41. Clark, E. A., Golub, T. R., Lander, E. S., and Hynes, R. O. (2000) Nature 406, 532-535
42. Smid, M., Wang, Y., Klijn, J. G., Sieuwerts, A. M., Zhang, Y., Atkins, D., Martens, J. W., and Foekens, J. A. (2006) J. Clin. Oncol. 24, 2261-2267
43. Nguyen, D. X., Bos, P. D., and Massagué, J. (2009) Nat. Rev. Cancer 9, 274-284
44. Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Kakonen, S. M., Cordón- Cardo, C., Guise, T. A., and Massagué, J. (2003) Cancer Cell 3, 537-549
45. Yin, J. J., Selander, K., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., Massagué, J., Mundy, G. R., and Guise, T. A. (1999) J. Clin. Invest. 103, 197-206
46. Park, B. K., Zhang, H., Zeng, Q., Dai, J., Keller, E. T., Giordano, T., Gu, K., Shah, V., Pei, L., Zarbo, R. J., McCauley, L., Shi, S., Chen, S., and Wang, C. Y. (2007) Nat. Med. 13, 62-69
47. Charafe-Jauffret, E., Ginestier, C., Monville, F., Finetti, P., Adélaïde, J., Cervera, N., Fekairi, S., Xerri, L., Jacquemier, J., Birnbaum, D., and Bertucci, F. (2006) Oncogene 25, 2273-2284
48. Gordon, L. A., Mulligan, K. T., Maxwell-Jones, H., Adams, M., Walker, R. A., and Jones, J. L. (2003) Int. J. Cancer 106, 8-16
49. Mani, S. A., Guo, W., Liao, M. J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M., Reinhard, F., Zhang, C. C., Shipitsin, M., Campbell, L. L., Polyak, K., Brisken, C., Yang, J., and Weinberg, R. A. (2008) Cell 133, 704-715
50. Li, F., Tiede, B., Massagué, J., and Kang, Y. (2007) Cell Res. 17, 3-14
51. Sheridan, C., Kishimoto, H., Fuchs, R. K., Mehrotra, S., Bhat-Nakshatri, P., Turner, C. H., Goulet, R., Jr., Badve, S., and Nakshatri, H. (2006) Breast Cancer Res. 8, R59
52. Edwards, D. R., and Murphy, G. (1998) Nature 394, 527-528
53. Minn, A. J., Kang, Y., Serganova, I., Gupta, G. P., Giri, D. D., Doubrovin, M., Ponomarev, V., Gerald, W. L., Blasberg, R., and Massagué, J. (2005) J. Clin. Invest. 115, 44-55
54. Toole, B. P. (2004) Nat. Rev. Cancer 4, 528-539
55. Orian-Rousseau, V. (2010) Eur. J. Cancer 46, 1271-1277
56. Avigdor, A., Goichberg, P., Shivtiel, S., Dar, A., Peled, A., Samira, S., Kollet, O., Hershkoviz, R., Alon, R., Hardan, I., Ben-Hur, H., Naor, D., Nagler, A., and Lapidot, T. (2004) Blood 103, 2981-2989
57. Yu, Q., and Stamenkovic, I. (1999) Genes Dev. 13, 35-48
58. Nakamura, H., Hiraga, T., Ninomiya, T., Hosoya, A., Fujisaki, N., Yoneda, T., and Ozawa, H. (2008) J. Bone Miner. Metab. 26, 642-647
59. Damm, S., Koefinger, P., Stefan, M., Wels, C., Mehes, G., Richtig, E., Kerl, H., Otte, M., and Schaider, H. (2010) J. Invest. Dermatol. 130, 1893-1903
60. Mishra, J. P., Mishra, S., Gee, K., and Kumar, A. (2005) J. Biol. Chem. 280, 26825-26837
61. Recio, J. A., and Merlino, G. (2003) Cancer Res. 63, 1576-1582
62. Fitzgerald, K. A., and O'Neill, L. A. (1999) J. Immunol. 162, 4920-4927
63. Abecassis, I., Maes, J., Carrier, J. L., Hillion, J., Goodhardt, M., Medjber, K., Wany, L., Lanotte, M., and Karniguian, A. (2008) Leukemia 22, 511-520
64. Kuncová, J., Urban, M., and Mandys, V. (2007) APMIS 115, 1194-1205
65. Zavrides, H. N., Zizi-Sermpetzoglou, A., Panousopoulos, D., Athanasas, G., Elemenoglou, I., and Peros, G. (2005) Folia Histochem. Cytobiol. 43, 31-36
66. Wang, S. P., Wang, W. L., Chang, Y. L., Wu, C. T., Chao, Y. C., Kao, S. H., Yuan, A., Lin, C. W., Yang, S. C., Chan, W. K., Li, K. C., Hong, T. M., and Yang, P. C. (2009) Nat. Cell Biol. 11, 694-704
67. Hsiao, M., Low, J., Dorn, E., Ku, D., Pattengale, P., Yeargin, J., and Haas, M. (1994) Am. J. Pathol. 145, 702-714
68. Cicalese, A., Bonizzi, G., Pasi, C. E., Faretta, M., Ronzoni, S., Giulini, B., Brisken, C., Minucci, S., Di Fiore, P. P., and Pelicci, P. G. (2009) Cell 138, 1083-1095
69. Dontu, G., Liu, S., and Wicha, M. S. (2005) Stem Cell Rev. 1, 207-213
70. Olivier, M., and Hainaut, P. (2001) Semin. Cancer Biol. 11, 353-360
71. Joerger, A. C., and Fersht, A. R. (2008) Annu. Rev. Biochem. 77, 557-582
72. Epstein, C. B., Attiyeh, E. F., Hobson, D. A., Silver, A. L., Broach, J. R., and Levine, A. J. (1998) Oncogene 16, 2115-2122
73. Monti, P., Campomenosi, P., Ciribilli, Y., Iannone, R., Inga, A., Abbondandolo, A., Resnick, M. A., and Fronza, G. (2002) Oncogene 21, 1641-1648
74. Willis, A., Jung, E. J., Wakefield, T., and Chen, X. (2004) Oncogene 23, 2330-2338
75. Brazda, V., Muller, P., Brozkova, K., and Vojtesek, B. (2006) Biochem. Biophys. Res. Commun. 351, 499-506
76. Chu, M. C., Selam, F. B., and Taylor, H. S. (2004) Cancer Biol. Ther. 3, 568-572
77. Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppe, J. P., Tong, F., Speed, T., Spellman, P. T., DeVries, S., Lapuk, A., Wang, N. J., Kuo, W. L., Stilwell, J. L., Pinkel, D., Albertson, D. G., Waldman, F. M., McCormick, F., Dickson, R. B., Johnson, M. D., Lippman, M., Ethier, S., Gazdar, A., and Gray, J. W. (2006) Cancer Cell 10, 515-527
78. Concin, N., Zeillinger, C., Tong, D., Stimpfl, M., König, M., Printz, D., Stonek, F., Schneeberger, C., Hefler, L., Kainz, C., Leodolter, S., Haas, O. A., and Zeillinger, R. (2003) Breast Cancer Res. Treat. 79, 37-46
79. Harvey, M., Vogel, H., Morris, D., Bradley, A., Bernstein, A., and Donehower, L. A. (1995) Nat. Genet. 9, 305-311
80. Liu, G., McDonnell, T. J., Montes de Oca Luna, R., Kapoor, M., Mims, B., El-Naggar, A. K., and Lozano, G. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 4174-4179
81. Hayes, D. F., Thor, A. D., Dressler, L. G., Weaver, D., Edgerton, S., Cowan, D., Broadwater, G., Goldstein, L. J., Martino, S., Ingle, J. N., Henderson, I. C., Norton, L., Winer, E. P., Hudis, C. A., Ellis, M. J., and Berry, D. A. (2007) N. Engl. J. Med. 357, 1496-1506
82. Hudis, C. A. (2007) N. Engl. J. Med. 357, 39-51