No Effect of Statins on Biochemical Outcomes After Radiotherapy for Localized Prostate Cancer

Urology

Volumn 73, Issue 1, 2009, Pages 158-162

  Soto, Daniel E ^a   Daignault, Stephanie ^b   Sandler, Howard M ^a   Ray, Michael E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ANDROGEN DEPRIVATION THERAPY; ARTICLE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER RISK; CONTROLLED STUDY; DRUG EFFECT; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; RADIATION DOSE;

AGED; COMBINED MODALITY THERAPY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 57849132574     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2008.02.055     Document Type: Article

References (21)

1. Demierre M.F., Higgins P.D., Gruber S.B., et al. Statins and cancer prevention. Nat Rev Cancer 5 (2005) 930-942
2. Cafforio P., Dammacco F., Gernone A., et al. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis 26 (2005) 883-991
3. Dimitroulakos J., Ye L.Y., Benzaquen M., et al. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. Clin Cancer Res 7 (2001) 158-167
4. Graaf M.R., Beiderbeck A.B., Egberts A.C., et al. The risk of cancer in users of statins. J Clin Oncol 22 (2004) 2388-2394
5. Miller A.C., Kariko K., Myers C.E., et al. Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation. Int J Cancer 53 (1993) 302-307
6. Fritz G., Brachetti C., and Kaina B. Lovastatin causes sensitization of HeLa cells to ionizing radiation-induced apoptosis by the abrogation of G2 blockage. Int J Radiat Biol. 79 (2003) 601-610
7. Tsai H.K., Katz M.S., Coen J.J., et al. Association of statin use with improved local control in patients treated with selective bladder preservation for muscle-invasive bladder cancer. Urology 68 (2006) 1188-1192
8. Katz M.S., Minsky B.D., Saltz L.B., et al. Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys 62 (2005) 1363-1370
9. Katz MZ, M. Marion C, Yamada Y, et al: Statin use is associated with improved biochemical outcome after high-dose radiotherapy for clinically localized prostate cancer (abstract). Presented at the American Society for Therapeutic Radiology and Oncology Annual Meeting, Salt Lake City, UT, 2003, vol 57, p S271.
10. Sharma N, Ruth K, Horwitz E, et al: Statin use prior to radiation therapy for prostate cancer does not improve outcome: the Fox Chase experience (abstract). Presented at the American Society for Therapeutic Radiology and Oncology Annual Meeting, Philadelphia, 2006, vol 66, p S366.
11. Katz M, D'Amico A, Cowan J, et al: Association of statin and NSAID use and prostate cancer outcomes: results from CaPSURE. (abstract). Presented at the American Society for Therapeutic Radiology and Oncology Annual Meeting, Philadelphia, 2006, vol 66, p S338.
12. Roach III M., Hanks G., Thames Jr. H., et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 65 (2006) 965-974
13. Ma J., Sehgal N.L., Ayanian J.Z., et al. National trends in statin use by coronary heart disease risk category. PLoS Med 2 (2005) e123
14. Mitka M. Expanding statin use to help more at-risk patients is causing financial heartburn. JAMA 290 (2003) 2243-2245
15. Bonovas S., Filioussi K., Tsavaris N., et al. Statins and cancer risk: a literature-based meta-analysis and meta-regression analysis of 35 randomized controlled trials. J Clin Oncol 24 (2006) 4808-4817
16. Coogan P.F., Rosenberg L., Palmer J.R., et al. Statin use and the risk of breast and prostate cancer. Epidemiology 13 (2002) 262-267
17. Platz E.A., Leitzmann M.F., Visvanathan K., et al. Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst 98 (2006) 1819-1825
18. Moyad M.A., Merrick G.S., Butler W.M., et al. Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer. Urol Nurs 26 (2006) 298-303
19. Moyad M.A., and Merrick G.S. Cholesterol, cholesterol lowering agents/statins, and urologic disease: part I-knowing your numbers. Urol Nurs 26 (2006) 156-159
20. Campbell M.J., Esserman L.J., Zhou Y., et al. Breast cancer growth prevention by statins. Cancer Res 66 (2006) 8707-8714
21. Seeger H., Wallwiener D., and Mueck A.O. Statins can inhibit proliferation of human breast cancer cells in vitro. Exp Clin Endocrinol Diabetes 111 (2003) 47-48