Differential expression of protease-activated receptors in monocytes from patients with primary antiphospholipid syndrome

Arthritis and Rheumatism

Volumn 62, Issue 3, 2010, Pages 869-877

  López Pedrera, Chary ^a   Aguirre, Maria Ángeles ^a   Buendía, Paula ^a   Barbarroja, Nuria ^b   Ruiz Limón, Patricia ^a   Collantes Estevez, Eduardo ^a   Velasco, Francisco ^a   Khamashta, Munther ^c   Cuadrado, Maria José ^c  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBOPLASTIN;

ADULT; AGED; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL ISOLATION; CELL SURFACE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; GENE OVEREXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOSIS; UPREGULATION;

ADULT; ANTIBODIES, ANTICARDIOLIPIN; ANTIBODIES, MONOCLONAL; ANTIPHOSPHOLIPID SYNDROME; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MONOCYTES; RECEPTOR CROSS-TALK; RECEPTORS, PROTEINASE-ACTIVATED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; THROMBOPLASTIN; THROMBOSIS;

EID: 77649099693     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27299     Document Type: Article

References (28)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306.
2. Urbanus RT, Derksen RH, de Groot PG. Current insight into diagnostics and pathophysiology of the antiphospholipid syndrome. Blood Rev 2008;22:93-105.
3. Salmon JE, de Groot PG. Pathogenic role of antiphospholipid antibodies. Lupus 2008;17:405-11.
4. Gabazza EC, Taguchi O, Kamada H, Hayashi T, Adachi Y, Suzuki K. Progress in the understanding of protease-activated receptors. Int J Hematol 2004;70:117-22.
5. Coughlin SR. How the protease thrombin talks to cells. Proc Natl Acad Sci U S A 1999;96:11023-7.
6. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000;407:258-64.
7. Oz MC, Liao H, Naka Y, Seldomridge A, Becker DN, Michler RE, et al. Ischemia-induced interleukin-8 release after human heart transplantation: a potential role for endothelial cells. Circulation 1995;92:II428-32.
8. Steffel J, Luscher TF, Tanner FC. Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. Circulation 2006;113:722-31.
9. Cuadrado MJ, Lopez-Pedrera C, Khamashta MA, Camps MT, Tinahones F, Torres A, et al. Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis Rheum 1997;40:834-41.
10. Amengual O, Atsumi T, Khamashta MA, Hughes GR. The role of the TF pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thromb Haemost 1998;79:276-81.
11. Dobado-Berrios PM, Lopez-Pedrera C, Velasco F, Angeles Aguirre M, Torres A, Cuadrado MJ. Increased levels of tissue factor mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome. Thromb Haemost 1999;82:1578-82.
12. Dobado-Berrios PM, Lopez-Pedrera C, Velasco F, Cuadrado MJ. The role of tissue factor in the antiphospholipid syndrome [review]. Arthritis Rheum 2001;44:2467-76.
13. Vega-Ostertag M, Kasper K, Swerlik R, Ferrara D, Harris EN, Pierangeli SS. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 2005;52:1545-54.
14. Lopez-Pedrera C, Buendia P, Cuadrado MJ, Siendones E, Angeles Aguirre M, Barbarroja N, et al. Antiphospholipid antibodies from antiphospholipid syndrome patients induce monocyte tissue factor expression through the simultaneous activation of NF-κB/Rel proteins via p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 2006;54:301-11.
15. Redecha P, Tilley R, Tencati M, Salmon JE, Kirchhofer D, Mackman R, et al. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 2007;110:2423-31.
16. Riewald M, Ruf W. Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor. Proc Natl Acad Sci U S A 2001;98:7742-7.
17. Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol 2005;25:1545-50.
18. Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 2005;3:1800-14.
19. Colognato R, Slupsky JR, Jendrach M, Burysek L, Syrovets T, Simmet T. Differential expression and regulation of proteaseactivated receptors in human peripheral monocytes and monocytederived antigen-presenting cells. Blood 2003;102:2645-52.
20. Brandt JT, Triplett DA, Alving B, Scharrer I, on behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Criteria for the diagnosis of lupus anticoagulants: an update. Thromb Haemost 1995;74:1185-90.
21. Redecha P, Tilley R, Tencati M, Salmon JE, Kirchhofer D, Mackman N, et al. Tissue factor: a link between C5a and neutrophils activation in antiphospholipid induced fetal injury. Blood 2007;110:2423-31.
22. Rhao LV, Pendurthy UR. Tissue factor-factor VIIa signalling. Arterioscler Thromb Vasc Biol 2005;25:47-56.
23. Chu AJ. Tissue factor mediates inflammation. Arch Biochem Biophys 2005;440:123-32.
24. Cuadrado MJ, Buendia P, Velasco F, Angeles Aguirre M, Barbarroja N, Torres LA, et al. Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome. J Thromb Haemost 2006;4:2461-9.
25. Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signalling. Nat Med 2004;10:502-9.
26. Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A 2000;97:5255-60.
27. Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 2004;279:23038-44.
28. Redecha P, Franzke CW, Ruf W, Mackman N, Girard G. Neutrophil activation by the tissue factor/factor VIIa/PAR-2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest 2008;118:3453-61.