Cellular senescence and the myth of Janus;La sénescence cellulaire: Un nouveau mythe de Janus?

Medecine/Sciences

Volumn 28, Issue 3, 2012, Pages 288-296

  Brondello, Jean Marc ^a   Prieur, Alexandre ^a   Philipot, Didier ^a   Lemaitre, Jean Marc ^a   Lenaers, Guy ^a   Piette, Jacques ^a   Dulić, Vjekoslav ^a  

^a UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYTOKINE; MICRORNA; PROTEIN P53; RETINOBLASTOMA PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL; AUTOPHAGY; BIOLOGICAL MODEL; CELL AGING; CELL CYCLE; CELL TRANSFORMATION; CELLS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA REPLICATION; DRUG ANTAGONISM; HUMAN; INFLAMMATION; MITOCHONDRION; MOUSE; PHENOTYPE; PHYSIOLOGY; REVIEW; SECRETION; SIGNAL TRANSDUCTION; TELOMERE HOMEOSTASIS;

ANIMALS; AUTOPHAGY; CELL AGING; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CELLS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYCLIN-DEPENDENT KINASES; CYTOKINES; DNA REPLICATION; HUMANS; INFLAMMATION; MICE; MICRORNAS; MITOCHONDRIA; MODELS, BIOLOGICAL; PHENOTYPE; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TELOMERE HOMEOSTASIS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860809242     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2012283017     Document Type: Review

References (52)

1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-36.
2. Gire V. La sénescence: une barrière télomé rique à l'immortalité ou une réponse cellulaire aux stress physiologiques ? Med Sci (Paris) 2005;21:491-7.
3. Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 1973;41:181-90.
4. Stein GH, Dulic V. Origins of G1 arrest in senescent human fibroblasts. Bioessays 1995;17:537-43.
5. D'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003;426:194-8. (Pubitemid 37442589)
6. Bischof O, Dejean A, Pineau P. Une revue de la sénescence cellulaire - Ami ou ennemi de la promotion tumorale ? Med Sci (Paris) 2009;25:153-60.
7. Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991;196:33-9. (Pubitemid 121006368)
8. Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer 2009;9:738-48.
9. Baus F, Gire V, Fisher D, et al. Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts. EMBO J 2003;22:3992-4002. (Pubitemid 36975725)
10. Chicas A, Wang X, Zhang C, et al. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell 2010;17:376-87.
11. Vernier M, Bourdeau V, Gaumont-Leclerc MF, et al. Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev 2011;25:41-50.
12. Krishnamurthy J, Torrice C, Ramsey MR, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004;114:1299-307. (Pubitemid 40385301)
13. Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16 (Ink4a)-positive senescent cells delays ageing-associated disorders. Nature 2011;479:232-6.
14. Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006;7:667-77. (Pubitemid 44268212)
15. Herbig U, Jobling WA, Chen BP, et al. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16 (INK4a). Mol Cell 2004;14:501-13. (Pubitemid 38648803)
16. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence. Genes Dev 2010;24:2463-79.
17. Gorospe M, Abdelmohsen K. Microregulators come of age in senescence. Trends Genet 2011;27:233-41.
18. Narita M, Nunez S, Heard E, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003;113:703-16. (Pubitemid 36724935)
19. Adams PD. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 2007;397:84-93. (Pubitemid 46992697)
20. Ferbeyre G, de Stanchina E, Querido E, et al. PML is induced by oncogenic ras and promotes premature senescence. Genes Dev 2000;14:2015-27. (Pubitemid 30637352)
21. Kennedy AL, McBryan T, Enders GH, et al. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust senescence associated heterochromatin foci. Cell Div 2010;5:16.
22. Di Micco R, Sulli G, Dobreva M, et al. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol 2011;13:292-302.
23. Prieur A, Besnard E, Babled A, Lemaitre JM. p53 and p16 (INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression. Nat Commun 2011;2:473.
24. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011;192:547-56.
25. Kuilman T, Michaloglou C, Vredeveld LC, et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008;133:1019-31. (Pubitemid 351787746)
26. Acosta JC, O'Loghlen A, Banito A, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008;133:1006-18. (Pubitemid 351795610)
27. Young AR, Narita M. Connecting autophagy to senescence in pathophysiology. Curr Opin Cell Biol 2010;22:234-40.
28. Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21-35.
29. Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci USA 2010;107:9660-4.
30. Pani G. From growing to secreting: New roles for mTOR in aging cells. Cell Cycle 2011;10:2450-3.
31. Narita M, Young AR, Arakawa S, et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 2011;332:966-70.
32. Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010;10:51-7.
33. Michaloglou C, Vredeveld LC, Soengas MS, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005;436:720-4. (Pubitemid 41117276)
34. Bartkova J, Rezaei N, Liontos M, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006;444:633-7. (Pubitemid 44864442)
35. Krizhanovsky V, Yon M, Dickins RA, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134:657-67.
36. Nardella C, Clohessy JG, Alimonti A, Pandolfi P P. Pro-senescence therapy for cancer treatment. Nat Rev Cancer 2011;11:503-11.
37. Coppe JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cellnonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008;6:2853-68.
38. Adams PD. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell 2009;36:2-14.
39. Kang TW, Yevsa T, Woller N, et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011;479:547-51.
40. Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell 2007;130:223-33. (Pubitemid 47081143)
41. Herbig U, Ferreira M, Condel L, et al. Cellular senescence in aging primates. Science 2006;311:1257. (Pubitemid 43334708)
42. Rodier F, Coppe J P, Patil CK, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009;11:973-9.
43. Brondello JM, Philipot D, Djouad F, et al. Cellular senescence is a common characteristic shared by preneoplasic and osteo-arthritic tissue. Open Rheumatol J 2010;4:10-4.
44. Serrano M, Blasco MA. Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol 2007;8:715-22. (Pubitemid 47312829)
45. Lapasset L, Milhavet O, Prieur A, et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev 2011;25:2248-53.
46. Mudhasani R, Zhu Z, Hutvagner G, et al. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol 2008;181:1055-63. (Pubitemid 351915481)
47. Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res 2007;35:7505-13.
48. Yoon YS, Yoon DS, Lim IK, et al. Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 2006;209:468-80. (Pubitemid 44484638)
49. Lenaers G, Amati-Bonneau P, Delettre C, et al. De la levure aux maladies neurodégénératives - Dix ans d'exploration des pathologies de la dynamique mitochondriale. Med Sci (Paris) 2010;26:836-41.
50. Sahin E, Colla S, Liesa M, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011;470:359-65.
51. Lacroix M, Linares L, Le Cam L. Le Yin et le Yang de la sénescence: est-il possible de vieillir sans développer de cancer ? Med Sci (Paris) 2012;28:245-7.
52. Rimmelé P, Zhang X, Ghaffari S. Rôle des facteurs de transcription FoxO dans la maintenance des cellules souches. Med Sci (Paris) 2012;28:250-4.