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Volumn 18, Issue 17, 2012, Pages 2395-2403

Therapeutic potential of perineural invasion, hypoxia and desmoplasia in pancreatic cancer

Author keywords

Desmoplasia; Hypoxia; Pancreatic cancer; Perineural invasion; Therapeutic targets

Indexed keywords

4 [BIS(2 CHLOROETHYL)OXIDOAMINO]PHENYLALANINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CHEMOKINE RECEPTOR CX3CR1; CYCLOOXYGENASE 2; FRACTALKINE; GAMMA SYNUCLEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUCOSE TRANSPORTER; HEME OXYGENASE 1; HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN ASSOCIATED GLYCOPROTEIN; NERVE CELL ADHESION MOLECULE; NERVE GROWTH FACTOR; NEUROTROPHIN; PLATELET DERIVED GROWTH FACTOR; POP33 FUSION PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SLT VEGF FUSION PROTEIN; TIRAPAZAMINE; TOP3 FUSION PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

EID: 84860439526     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128112092395     Document Type: Review
Times cited : (47)

References (117)
  • 1
    • 33745117233 scopus 로고    scopus 로고
    • The epidemiology of pancreatic cancer in the United States: Changes below the surface
    • Shaib YH, Davila JA, El-Serag HB. The epidemiology of pancreatic cancer in the United States: changes below the surface. Aliment Pharmacol Ther 2006; 24: 87-94.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 87-94
    • Shaib, Y.H.1    Davila, J.A.2    El-Serag, H.B.3
  • 4
    • 55249085150 scopus 로고    scopus 로고
    • Cancer of the pancreas: Are we making progress? A review of studies in the US Oncology Research Network
    • Cartwright T, Richards DA, Boehm KA. Cancer of the pancreas: are we making progress? A review of studies in the US Oncology Research Network. Cancer Control 2008; 15: 308-13.
    • (2008) Cancer Control , vol.15 , pp. 308-313
    • Cartwright, T.1    Richards, D.A.2    Boehm, K.A.3
  • 5
    • 79952265699 scopus 로고    scopus 로고
    • Relationship between Neural Alteration and Perineural Invasion in Pancreatic Cancer Patients with Hyperglycemia
    • Li JH, Ma QY, Liu H, et al. Relationship between Neural Alteration and Perineural Invasion in Pancreatic Cancer Patients with Hyperglycemia. Plos One 2011; 6(2): e17385.
    • (2011) Plos One , vol.6 , Issue.2
    • Li, J.H.1    Ma, Q.Y.2    Liu, H.3
  • 6
    • 79952040479 scopus 로고    scopus 로고
    • Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1alpha under normoxic condition
    • Zhang M, Ma Q, Hu H, et al. Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1alpha under normoxic condition. Cancer Lett 2011; 303: 108-17.
    • (2011) Cancer Lett , vol.303 , pp. 108-117
    • Zhang, M.1    Ma, Q.2    Hu, H.3
  • 7
    • 74549184487 scopus 로고    scopus 로고
    • HIF-1 alpha links betaadrenoceptor agonists and pancreatic cancer cells under normoxic condition
    • Hu HT, Ma QY, Zhang D, et al. HIF-1 alpha links betaadrenoceptor agonists and pancreatic cancer cells under normoxic condition. Acta Pharmacol Sin 2010; 31: 102-10.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 102-110
    • Hu, H.T.1    Ma, Q.Y.2    Zhang, D.3
  • 8
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    • Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 2007; 6: 1186-97.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1186-1197
    • Mahadevan, D.1    von Hoff, D.D.2
  • 9
    • 0038068132 scopus 로고    scopus 로고
    • Neural invasion in the staging of pancreatic cancer
    • Pour PM, Bell RH, Batra SK. Neural invasion in the staging of pancreatic cancer. Pancreas 2003; 26: 322-5.
    • (2003) Pancreas , vol.26 , pp. 322-325
    • Pour, P.M.1    Bell, R.H.2    Batra, S.K.3
  • 10
    • 0026317929 scopus 로고
    • Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus
    • Kayahara M, Nagakawa T, Konishi I, Ueno K, Ohta T, Miyazaki I. Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus. Int J Pancreatol 1991; 10: 105-11.
    • (1991) Int J Pancreatol , vol.10 , pp. 105-111
    • Kayahara, M.1    Nagakawa, T.2    Konishi, I.3    Ueno, K.4    Ohta, T.5    Miyazaki, I.6
  • 12
    • 0037635163 scopus 로고    scopus 로고
    • Neural invasion in pancreatic carcinoma
    • Liu B, Lu KY. Neural invasion in pancreatic carcinoma. Hepatobiliary Pancreat Dis Int 2002; 1: 469-76.
    • (2002) Hepatobiliary Pancreat Dis Int , vol.1 , pp. 469-476
    • Liu, B.1    Lu, K.Y.2
  • 13
    • 0026606786 scopus 로고
    • Clinicopathological study on neural invasion to the extrapancreatic nerve plexus in pancreatic cancer
    • Nagakawa T, Kayahara M, Ueno K, Ohta T, Konishi I, Miyazaki I. Clinicopathological study on neural invasion to the extrapancreatic nerve plexus in pancreatic cancer. Hepatogastroenterology 1992; 39: 51-5.
    • (1992) Hepatogastroenterology , vol.39 , pp. 51-55
    • Nagakawa, T.1    Kayahara, M.2    Ueno, K.3    Ohta, T.4    Konishi, I.5    Miyazaki, I.6
  • 14
    • 68149170070 scopus 로고    scopus 로고
    • Perineural invasion in cancer: A review of the literature
    • Liebig C, Ayala G, Wilks JA, Berger DH, Albo D. Perineural invasion in cancer: a review of the literature. Cancer 2009; 115: 3379-91.
    • (2009) Cancer , vol.115 , pp. 3379-3391
    • Liebig, C.1    Ayala, G.2    Wilks, J.A.3    Berger, D.H.4    Albo, D.5
  • 15
    • 33748125151 scopus 로고    scopus 로고
    • The neurotrophic factor artemin promotes pancreatic cancer invasion
    • Ceyhan GO, Giese NA, Erkan M, et al. The neurotrophic factor artemin promotes pancreatic cancer invasion. Annals of Surgery 2006; 244: 274-81.
    • (2006) Annals of Surgery , vol.244 , pp. 274-281
    • Ceyhan, G.O.1    Giese, N.A.2    Erkan, M.3
  • 16
    • 0032792960 scopus 로고    scopus 로고
    • Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer
    • Zhu Z, Friess H, diMola FF, et al. Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. J Clin Oncol 1999; 17: 2419-28.
    • (1999) J Clin Oncol , vol.17 , pp. 2419-2428
    • Zhu, Z.1    Friess, H.2    diMola, F.F.3
  • 17
    • 0035132668 scopus 로고    scopus 로고
    • Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells
    • Zhu ZW, Friess H, Wang L, et al. Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells. Clinical Cancer Research 2001; 7: 105-12.
    • (2001) Clinical Cancer Research , vol.7 , pp. 105-112
    • Zhu, Z.W.1    Friess, H.2    Wang, L.3
  • 18
    • 33846193297 scopus 로고    scopus 로고
    • Enhanced survival in perineural invasion of pancreatic cancer: An in vitro approach
    • Dai H, Li R, Wheeler T, et al. Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach. Hum Pathol 2007; 38: 299-307.
    • (2007) Hum Pathol , vol.38 , pp. 299-307
    • Dai, H.1    Li, R.2    Wheeler, T.3
  • 20
    • 34748883778 scopus 로고    scopus 로고
    • The nature of neural invasion by pancreatic cancer
    • Kayahara M, Nakagawara H, Kitagawa H, Ohta T. The nature of neural invasion by pancreatic cancer. Pancreas 2007; 35: 218-23.
    • (2007) Pancreas , vol.35 , pp. 218-223
    • Kayahara, M.1    Nakagawara, H.2    Kitagawa, H.3    Ohta, T.4
  • 21
    • 0036842111 scopus 로고    scopus 로고
    • Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells
    • Zhu Z, Kleeff J, Kayed H, et al. Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells. Molecular Carcinogenesis 2002; 35: 138-47.
    • (2002) Molecular Carcinogenesis , vol.35 , pp. 138-147
    • Zhu, Z.1    Kleeff, J.2    Kayed, H.3
  • 22
    • 0027410846 scopus 로고
    • Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein
    • Djakiew D, Pflug BR, Delsite R, et al. Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein. Cancer Res 1993; 53: 1416-20.
    • (1993) Cancer Res , vol.53 , pp. 1416-1420
    • Djakiew, D.1    Pflug, B.R.2    Delsite, R.3
  • 23
    • 0032939723 scopus 로고    scopus 로고
    • Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: Expression patterns and effects on in vitro invasive behavior
    • Miknyoczki SJ, Lang D, Huang L, Klein-Szanto AJ, Dionne CA, Ruggeri BA. Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer 1999; 81: 417-27.
    • (1999) Int J Cancer , vol.81 , pp. 417-427
    • Miknyoczki, S.J.1    Lang, D.2    Huang, L.3    Klein-Szanto, A.J.4    Dionne, C.A.5    Ruggeri, B.A.6
  • 24
    • 0031054680 scopus 로고    scopus 로고
    • Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells
    • Geldof AA, De Kleijn MA, Rao BR, Newling DW. Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells. J Cancer Res Clin Oncol 1997; 123: 107-12.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 107-112
    • Geldof, A.A.1    de Kleijn, M.A.2    Rao, B.R.3    Newling, D.W.4
  • 25
    • 39049102137 scopus 로고    scopus 로고
    • Nerve growth factor is a potential therapeutic target in breast cancer
    • Adriaenssens E, Vanhecke E, Saule P, et al. Nerve growth factor is a potential therapeutic target in breast cancer. Cancer Res 2008; 68: 346-51.
    • (2008) Cancer Res , vol.68 , pp. 346-351
    • Adriaenssens, E.1    Vanhecke, E.2    Saule, P.3
  • 26
    • 33646551440 scopus 로고    scopus 로고
    • The neurotrophic receptor TrkB: A drug target in anti-cancer therapy?
    • Desmet CJ, Peeper DS. The neurotrophic receptor TrkB: a drug target in anti-cancer therapy? Cell Mol Life Sci 2006; 63: 755-9.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 755-759
    • Desmet, C.J.1    Peeper, D.S.2
  • 28
    • 0029929228 scopus 로고    scopus 로고
    • Neurotrophin stimulation of human melanoma cell invasion: Selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations
    • Marchetti D, McQuillan DJ, Spohn WC, Carson DD, Nicolson GL. Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Cancer Res 1996; 56: 2856-63.
    • (1996) Cancer Res , vol.56 , pp. 2856-2863
    • Marchetti, D.1    McQuillan, D.J.2    Spohn, W.C.3    Carson, D.D.4    Nicolson, G.L.5
  • 29
    • 79952265699 scopus 로고    scopus 로고
    • Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia
    • Li J, Ma Q, Liu H, et al. Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia. PLoS One 2011; 6: e17385.
    • (2011) PLoS One , vol.6
    • Li, J.1    Ma, Q.2    Liu, H.3
  • 30
    • 7244238297 scopus 로고    scopus 로고
    • Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells
    • Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ. Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis 2004; 21: 285-92.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 285-292
    • Okada, Y.1    Eibl, G.2    Guha, S.3    Duffy, J.P.4    Reber, H.A.5    Hines, O.J.6
  • 31
    • 33744929384 scopus 로고    scopus 로고
    • Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma
    • Ayala GE, Dai H, Tahir SA, et al. Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma. Cancer Research 2006; 66: 5159-64.
    • (2006) Cancer Research , vol.66 , pp. 5159-5164
    • Ayala, G.E.1    Dai, H.2    Tahir, S.A.3
  • 32
    • 0033017130 scopus 로고    scopus 로고
    • Experimental implication of celiac ganglionotropic invasion of pancreatic-cancer cells bearing c-ret proto-oncogene with reference to glial-cell-line-derived neurotrophic factor (GDNF)
    • Okada Y, Takeyama H, Sato M, et al. Experimental implication of celiac ganglionotropic invasion of pancreatic-cancer cells bearing c-ret proto-oncogene with reference to glial-cell-line-derived neurotrophic factor (GDNF). Int J Cancer 1999; 81: 67-73.
    • (1999) Int J Cancer , vol.81 , pp. 67-73
    • Okada, Y.1    Takeyama, H.2    Sato, M.3
  • 33
    • 75149195316 scopus 로고    scopus 로고
    • Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves
    • Gil Z, Cavel O, Kelly K, et al. Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J Natl Cancer Inst 2010; 102: 107-18.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 107-118
    • Gil, Z.1    Cavel, O.2    Kelly, K.3
  • 34
    • 0042328053 scopus 로고    scopus 로고
    • Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer
    • Okada Y, Eibl G, Duffy JP, Reber HA, Hines OJ. Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer. Surgery 2003; 134: 293-9.
    • (2003) Surgery , vol.134 , pp. 293-299
    • Okada, Y.1    Eibl, G.2    Duffy, J.P.3    Reber, H.A.4    Hines, O.J.5
  • 35
    • 0242610430 scopus 로고    scopus 로고
    • Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer
    • Ketterer K, Rao S, Friess H, Weiss J, Buchler MW, Korc M. Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer. Clin Cancer Res 2003; 9: 5127-36.
    • (2003) Clin Cancer Res , vol.9 , pp. 5127-5136
    • Ketterer, K.1    Rao, S.2    Friess, H.3    Weiss, J.4    Buchler, M.W.5    Korc, M.6
  • 36
    • 0036741845 scopus 로고    scopus 로고
    • Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by brain-derived neurotrophic factor
    • Kowalski PJ, Paulino AF. Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by brain-derived neurotrophic factor. Hum Pathol 2002; 33: 933-6.
    • (2002) Hum Pathol , vol.33 , pp. 933-936
    • Kowalski, P.J.1    Paulino, A.F.2
  • 37
    • 0032905654 scopus 로고    scopus 로고
    • Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion
    • Kameda K, Shimada H, Ishikawa T, et al. Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion. Cancer Lett 1999; 137: 201-7.
    • (1999) Cancer Lett , vol.137 , pp. 201-207
    • Kameda, K.1    Shimada, H.2    Ishikawa, T.3
  • 38
    • 0027262443 scopus 로고
    • Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer
    • Seki H, Tanaka J, Sato Y, Kato Y, Umezawa A, Koyama K. Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer. J Surg Oncol 1993; 53: 78-83.
    • (1993) J Surg Oncol , vol.53 , pp. 78-83
    • Seki, H.1    Tanaka, J.2    Sato, Y.3    Kato, Y.4    Umezawa, A.5    Koyama, K.6
  • 39
    • 42949129576 scopus 로고    scopus 로고
    • Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells
    • Schreiber SC, Giehl K, Kastilan C, et al. Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells. Gastroenterology 2008; 134: 1555-66.
    • (2008) Gastroenterology , vol.134 , pp. 1555-1566
    • Schreiber, S.C.1    Giehl, K.2    Kastilan, C.3
  • 40
    • 0034945537 scopus 로고    scopus 로고
    • N-CAM modulates tumour-cell adhesion to matrix by inducing FGFreceptor signalling
    • Cavallaro U, Niedermeyer J, Fuxa M, Christofori G. N-CAM modulates tumour-cell adhesion to matrix by inducing FGFreceptor signalling. Nat Cell Biol 2001; 3: 650-7.
    • (2001) Nat Cell Biol , vol.3 , pp. 650-657
    • Cavallaro, U.1    Niedermeyer, J.2    Fuxa, M.3    Christofori, G.4
  • 41
    • 35948983334 scopus 로고    scopus 로고
    • MUC1 is a counter-receptor for myelinassociated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion
    • Swanson BJ, McDermott KM, Singh PK, Eggers JP, Crocker PR, Hollingsworth MA. MUC1 is a counter-receptor for myelinassociated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer Research 2007; 67: 10222-9.
    • (2007) Cancer Research , vol.67 , pp. 10222-10229
    • Swanson, B.J.1    McDermott, K.M.2    Singh, P.K.3    Eggers, J.P.4    Crocker, P.R.5    Hollingsworth, M.A.6
  • 42
    • 0035205898 scopus 로고    scopus 로고
    • Tumor deposition of laminin-5 and the relationship with perineural invasion
    • Anderson TD, Feldman M, Weber RS, Ziober AF, Ziober BL. Tumor deposition of laminin-5 and the relationship with perineural invasion. Laryngoscope 2001; 111: 2140-3.
    • (2001) Laryngoscope , vol.111 , pp. 2140-2143
    • Anderson, T.D.1    Feldman, M.2    Weber, R.S.3    Ziober, A.F.4    Ziober, B.L.5
  • 43
    • 55349148665 scopus 로고    scopus 로고
    • The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma
    • Marchesi F, Piemonti L, Fedele G, et al. The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res 2008; 68: 9060-9.
    • (2008) Cancer Res , vol.68 , pp. 9060-9069
    • Marchesi, F.1    Piemonti, L.2    Fedele, G.3
  • 44
    • 33745573660 scopus 로고    scopus 로고
    • Control of microglial neurotoxicity by the fractalkine receptor
    • Cardona AE, Pioro EP, Sasse ME, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 2006; 9: 917-24.
    • (2006) Nat Neurosci , vol.9 , pp. 917-924
    • Cardona, A.E.1    Pioro, E.P.2    Sasse, M.E.3
  • 45
    • 0031036347 scopus 로고    scopus 로고
    • A new class of membrane-bound chemokine with a CX3C motif
    • Bazan JF, Bacon KB, Hardiman G, et al. A new class of membrane-bound chemokine with a CX3C motif. Nature 1997; 385: 640-4.
    • (1997) Nature , vol.385 , pp. 640-644
    • Bazan, J.F.1    Bacon, K.B.2    Hardiman, G.3
  • 46
    • 0030949298 scopus 로고    scopus 로고
    • Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    • Pan Y, Lloyd C, Zhou H, et al. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 1997; 387: 611-7.
    • (1997) Nature , vol.387 , pp. 611-617
    • Pan, Y.1    Lloyd, C.2    Zhou, H.3
  • 47
    • 4544252839 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
    • Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci 2004; 20: 1150-60.
    • (2004) Eur J Neurosci , vol.20 , pp. 1150-1160
    • Verge, G.M.1    Milligan, E.D.2    Maier, S.F.3    Watkins, L.R.4    Naeve, G.S.5    Foster, A.C.6
  • 48
    • 77955088689 scopus 로고    scopus 로고
    • Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer
    • Marchesi F, Locatelli M, Solinas G, Erreni M, Allavena P, Mantovani A. Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer. J Neuroimmunol 2010; 224: 39-44.
    • (2010) J Neuroimmunol , vol.224 , pp. 39-44
    • Marchesi, F.1    Locatelli, M.2    Solinas, G.3    Erreni, M.4    Allavena, P.5    Mantovani, A.6
  • 49
    • 65249187279 scopus 로고    scopus 로고
    • Synuclein-gamma Is Closely Involved in Perineural Invasion and Distant Metastasis in Mouse Models and Is a Novel Prognostic Factor in Pancreatic Cancer
    • Hibi T, Mori T, Fukuma M, et al. Synuclein-gamma Is Closely Involved in Perineural Invasion and Distant Metastasis in Mouse Models and Is a Novel Prognostic Factor in Pancreatic Cancer. Clinical Cancer Research 2009; 15: 2864-71.
    • (2009) Clinical Cancer Research , vol.15 , pp. 2864-2871
    • Hibi, T.1    Mori, T.2    Fukuma, M.3
  • 50
    • 77957875453 scopus 로고    scopus 로고
    • Rhabdastrellic Acid-A Induced Autophagy-Associated Cell Death through Blocking Akt Pathway in Human Cancer Cells
    • Li DD, Guo JF, Huang JJ, et al. Rhabdastrellic Acid-A Induced Autophagy-Associated Cell Death through Blocking Akt Pathway in Human Cancer Cells. Plos One 2010; 5: -.
    • (2010) Plos One , vol.5
    • Li, D.D.1    Guo, J.F.2    Huang, J.J.3
  • 51
    • 33947498749 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis
    • Wang F, Li SS, Segersvard R, et al. Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis. Am J Pathol 2007; 170: 469-77.
    • (2007) Am J Pathol , vol.170 , pp. 469-477
    • Wang, F.1    Li, S.S.2    Segersvard, R.3
  • 52
    • 19944434272 scopus 로고    scopus 로고
    • Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: Negative correlation of microvascular density and VEGF expression with tumour progression
    • Couvelard A, O'Toole D, Turley H, et al. Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. Br J Cancer 2005; 92: 94-101.
    • (2005) Br J Cancer , vol.92 , pp. 94-101
    • Couvelard, A.1    O'Toole, D.2    Turley, H.3
  • 53
    • 33845582804 scopus 로고    scopus 로고
    • Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes
    • Li XQ, Zhang LJ, Meshinchi S, et al. Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes 2006; 55: 2965-73.
    • (2006) Diabetes , vol.55 , pp. 2965-2973
    • Li, X.Q.1    Zhang, L.J.2    Meshinchi, S.3
  • 54
    • 7044221820 scopus 로고    scopus 로고
    • Microvascular development: Learning from pancreatic islets
    • Konstantinova I, Lammert E. Microvascular development: learning from pancreatic islets. Bioessays 2004; 26: 1069-75.
    • (2004) Bioessays , vol.26 , pp. 1069-1075
    • Konstantinova, I.1    Lammert, E.2
  • 55
    • 0038282482 scopus 로고    scopus 로고
    • The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
    • Unruh A, Ressel A, Mohamed HG, et al. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 2003; 22: 3213-20.
    • (2003) Oncogene , vol.22 , pp. 3213-3220
    • Unruh, A.1    Ressel, A.2    Mohamed, H.G.3
  • 56
    • 67649989638 scopus 로고    scopus 로고
    • Phase II Study of Tirapazamine, Cisplatin, and Etoposide and Concurrent Thoracic Radiotherapy for Limited-Stage Small-Cell Lung Cancer: SWOG 0222
    • Le QTX, Moon J, Redman M, et al. Phase II Study of Tirapazamine, Cisplatin, and Etoposide and Concurrent Thoracic Radiotherapy for Limited-Stage Small-Cell Lung Cancer: SWOG 0222. J Clin Oncol 2009; 27: 3014-9.
    • (2009) J Clin Oncol , vol.27 , pp. 3014-3019
    • Le, Q.T.X.1    Moon, J.2    Redman, M.3
  • 57
    • 78649738532 scopus 로고    scopus 로고
    • Suppression of Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha) by Tirapazamine Is Dependent on eIF2 alpha Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway
    • Zhang J, Cao J, Weng QJ, et al. Suppression of Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha) by Tirapazamine Is Dependent on eIF2 alpha Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway. Plos One 2010; 5: -.
    • (2010) Plos One , vol.5
    • Zhang, J.1    Cao, J.2    Weng, Q.J.3
  • 58
    • 38349092288 scopus 로고    scopus 로고
    • Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 alpha
    • Koh MY, Spivak-Kroizman T, Venturini S, et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 alpha. Mol Cancer Ther 2008; 7: 90-100.
    • (2008) Mol Cancer Ther , vol.7 , pp. 90-100
    • Koh, M.Y.1    Spivak-Kroizman, T.2    Venturini, S.3
  • 59
    • 4444369682 scopus 로고    scopus 로고
    • Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1 alpha
    • Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1 alpha. Mol Cancer Ther 2004; 3: 233-44.
    • (2004) Mol Cancer Ther , vol.3 , pp. 233-244
    • Welsh, S.1    Williams, R.2    Kirkpatrick, L.3    Paine-Murrieta, G.4    Powis, G.5
  • 60
    • 77954425345 scopus 로고    scopus 로고
    • Treatment with HIF-1 alpha Antagonist PX-478 Inhibits Progression and Spread of Orthotopic Human Small Cell Lung Cancer and Lung Adenocarcinoma in Mice
    • Jacoby JJ, Erez B, Korshunova MV, et al. Treatment with HIF-1 alpha Antagonist PX-478 Inhibits Progression and Spread of Orthotopic Human Small Cell Lung Cancer and Lung Adenocarcinoma in Mice. J Thorac Oncol 2010; 5: 940-9.
    • (2010) J Thorac Oncol , vol.5 , pp. 940-949
    • Jacoby, J.J.1    Erez, B.2    Korshunova, M.V.3
  • 61
    • 53449096820 scopus 로고    scopus 로고
    • PX-478, an inhibitor of hypoxia-inducible factor- 1 alpha, enhances radiosensitivity of prostate carcinoma cells
    • Palayoor ST, Mitchell JB, Cerna D, DeGraff W, John-Aryankalayil M, Coleman CN. PX-478, an inhibitor of hypoxia-inducible factor- 1 alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer 2008; 123: 2430-7.
    • (2008) Int J Cancer , vol.123 , pp. 2430-2437
    • Palayoor, S.T.1    Mitchell, J.B.2    Cerna, D.3    de Graff, W.4    John-Aryankalayil, M.5    Coleman, C.N.6
  • 62
    • 66449118481 scopus 로고    scopus 로고
    • The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
    • Schwartz DL, Powis G, Thitai-Kumar A, et al. The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther 2009; 8: 947-58.
    • (2009) Mol Cancer Ther , vol.8 , pp. 947-958
    • Schwartz, D.L.1    Powis, G.2    Thitai-Kumar, A.3
  • 63
    • 66149164442 scopus 로고    scopus 로고
    • Selective Killing of Hypoxia-Inducible Factor-1-Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer
    • Kizaka-Kondoh S, Itasaka S, Zeng LH, et al. Selective Killing of Hypoxia-Inducible Factor-1-Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer. Clin Cancer Res 2009; 15: 3433-41.
    • (2009) Clin Cancer Res , vol.15 , pp. 3433-3441
    • Kizaka-Kondoh, S.1    Itasaka, S.2    Zeng, L.H.3
  • 64
  • 65
    • 0036531825 scopus 로고    scopus 로고
    • Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells
    • Harada H, Hiraoka M, Kizaka-Kondoh S. Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res 2002; 62: 2013-8.
    • (2002) Cancer Res , vol.62 , pp. 2013-2018
    • Harada, H.1    Hiraoka, M.2    Kizaka-Kondoh, S.3
  • 66
    • 0035213434 scopus 로고    scopus 로고
    • Targeting endothelial cells overexpressing VEGFR-2: Selective toxicity of Shiga-like toxin-VEGF fusion proteins
    • Backer MV, Backer JM. Targeting endothelial cells overexpressing VEGFR-2: Selective toxicity of Shiga-like toxin-VEGF fusion proteins. Bioconjugate Chem 2001; 12: 1066-73.
    • (2001) Bioconjugate Chem , vol.12 , pp. 1066-1073
    • Backer, M.V.1    Backer, J.M.2
  • 67
    • 33644701668 scopus 로고    scopus 로고
    • Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature
    • Backer MV, Gaynutdinov TI, Patel V, et al. Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Mol Cancer Ther 2005; 4: 1423-9.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1423-1429
    • Backer, M.V.1    Gaynutdinov, T.I.2    Patel, V.3
  • 68
    • 77957797119 scopus 로고    scopus 로고
    • Specific Targeting of Tumor Endothelial Cells by a Shiga-like Toxin- Vascular Endothelial Growth Factor Fusion Protein as a Novel Treatment Strategy for Pancreatic Cancer
    • Hotz B, Backer MV, Backer JM, Buhr HJ, Hotz HG. Specific Targeting of Tumor Endothelial Cells by a Shiga-like Toxin- Vascular Endothelial Growth Factor Fusion Protein as a Novel Treatment Strategy for Pancreatic Cancer. Neoplasia 2010; 12: 797-U148.
    • (2010) Neoplasia , vol.12
    • Hotz, B.1    Backer, M.V.2    Backer, J.M.3    Buhr, H.J.4    Hotz, H.G.5
  • 69
    • 4644317795 scopus 로고    scopus 로고
    • Desmoplastic reaction in pancreatic cancer - Role of pancreatic stellate cells
    • Apte MV, Park S, Phillips PA, et al. Desmoplastic reaction in pancreatic cancer - Role of pancreatic stellate cells. Pancreas 2004; 29: 179-87.
    • (2004) Pancreas , vol.29 , pp. 179-187
    • Apte, M.V.1    Park, S.2    Phillips, P.A.3
  • 70
    • 0038179900 scopus 로고    scopus 로고
    • Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    • Logsdon CD, Simeone DM, Binkley C, et al. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003; 63: 2649-57.
    • (2003) Cancer Res , vol.63 , pp. 2649-2657
    • Logsdon, C.D.1    Simeone, D.M.2    Binkley, C.3
  • 72
    • 54249088477 scopus 로고    scopus 로고
    • Pancreatic stellate cells and pancreatic cancer cells: An unholy alliance
    • Vonlaufen A, Phillips PA, Xu ZH, e al. Pancreatic stellate cells and pancreatic cancer cells: An unholy alliance. Cancer Res 2008; 68: 7707-10.
    • (2008) Cancer Res , vol.68 , pp. 7707-7710
    • Vonlaufen, A.1    Phillips, P.A.2    Xu, Z.H.3
  • 73
    • 0036186862 scopus 로고    scopus 로고
    • Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas
    • Yen TNF, Aardal NP, Bronner MP, et al. Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas. Surgery 2002; 131: 129-34.
    • (2002) Surgery , vol.131 , pp. 129-134
    • Yen, T.N.F.1    Aardal, N.P.2    Bronner, M.P.3
  • 74
    • 0036934057 scopus 로고    scopus 로고
    • TGF beta-induced fibrogenesis of the pancreas
    • Menke A, Adler G. TGF beta-induced fibrogenesis of the pancreas. Int J Gastro Cancer 2002; 31: 41-6.
    • (2002) Int J Gastro Cancer , vol.31 , pp. 41-46
    • Menke, A.1    Adler, G.2
  • 75
    • 16344384885 scopus 로고    scopus 로고
    • Mechanisms of pancreatic fibrosis
    • Apte MV, Wilson JS. Mechanisms of pancreatic fibrosis. Digest Dis 2004; 22: 273-9.
    • (2004) Digest Dis , vol.22 , pp. 273-279
    • Apte, M.V.1    Wilson, J.S.2
  • 76
    • 8444244417 scopus 로고    scopus 로고
    • Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma
    • Armstrong T, Packham G, Murphy LB, et al. Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Clin Cancer Res 2004; 10: 7427-37.
    • (2004) Clin Cancer Res , vol.10 , pp. 7427-7437
    • Armstrong, T.1    Packham, G.2    Murphy, L.B.3
  • 77
    • 13644257727 scopus 로고    scopus 로고
    • The molecular basis of pancreatic fibrosis - Common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma
    • Binkley CE, Zhang LZ, Greenson JK, et al. The molecular basis of pancreatic fibrosis - Common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma. Pancreas 2004; 29: 254-63.
    • (2004) Pancreas , vol.29 , pp. 254-263
    • Binkley, C.E.1    Zhang, L.Z.2    Greenson, J.K.3
  • 78
    • 4444259183 scopus 로고    scopus 로고
    • Pancreatic tumor cells influence the composition of the extracellular matrix
    • Koninger J, Giese T, di Mola FF, et al. Pancreatic tumor cells influence the composition of the extracellular matrix. Biochem Bioph Res Co 2004; 322: 943-9.
    • (2004) Biochem Bioph Res Co , vol.322 , pp. 943-949
    • Koninger, J.1    Giese, T.2    di Mola, F.F.3
  • 79
    • 4644309325 scopus 로고    scopus 로고
    • Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway
    • Yoshida S, Yokota T, Ujiki M, et al. Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway. Biochem Bioph Res Co 2004; 323: 1241-5.
    • (2004) Biochem Bioph Res Co , vol.323 , pp. 1241-1245
    • Yoshida, S.1    Yokota, T.2    Ujiki, M.3
  • 80
    • 17144404527 scopus 로고    scopus 로고
    • Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    • Bachem MG, Schunemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 2005; 128: 907-21.
    • (2005) Gastroenterology , vol.128 , pp. 907-921
    • Bachem, M.G.1    Schunemann, M.2    Ramadani, M.3
  • 81
    • 0242349254 scopus 로고    scopus 로고
    • Stellate cell activation in alcoholic pancreatitis
    • Apte MV, Wilson JS. Stellate cell activation in alcoholic pancreatitis. Pancreas 2003; 27: 316-20.
    • (2003) Pancreas , vol.27 , pp. 316-320
    • Apte, M.V.1    Wilson, J.S.2
  • 82
    • 0032954505 scopus 로고    scopus 로고
    • Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
    • Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999; 44: 534-41.
    • (1999) Gut , vol.44 , pp. 534-541
    • Apte, M.V.1    Haber, P.S.2    Darby, S.J.3
  • 83
    • 0033969266 scopus 로고    scopus 로고
    • Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implications in pathogenesis of pancreas fibrosis
    • Luttenberger T, Schmid-Kotsas A, Menke A, et al. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implications in pathogenesis of pancreas fibrosis. Lab Invest 2000; 80: 47-55.
    • (2000) Lab Invest , vol.80 , pp. 47-55
    • Luttenberger, T.1    Schmid-Kotsas, A.2    Menke, A.3
  • 84
    • 0034870206 scopus 로고    scopus 로고
    • Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells
    • Schneider E, Schmid-Kotsas A, Zhao JS, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol-Cell Ph 2001; 281: C532-C43.
    • (2001) Am J Physiol-Cell Ph , vol.281
    • Schneider, E.1    Schmid-Kotsas, A.2    Zhao, J.S.3
  • 85
    • 0036098613 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis
    • Shek FWT, Benyon RC, Walker FM, et al. Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol 2002; 160: 1787-98.
    • (2002) Am J Pathol , vol.160 , pp. 1787-1798
    • Shek, F.W.T.1    Benyon, R.C.2    Walker, F.M.3
  • 86
    • 0036282292 scopus 로고    scopus 로고
    • Pancreatic stellate cells respond to inflammatory cytokines: Potential role in chronic pancreatitis
    • Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 2002; 50: 535-41.
    • (2002) Gut , vol.50 , pp. 535-541
    • Mews, P.1    Phillips, P.2    Fahmy, R.3
  • 87
    • 0037962905 scopus 로고    scopus 로고
    • Cell migration: A novel aspect of pancreatic stellate cell biology
    • Phillips PA, Wu MJ, Kumar RK, et al. Cell migration: a novel aspect of pancreatic stellate cell biology. Gut 2003; 52: 677-82.
    • (2003) Gut , vol.52 , pp. 677-682
    • Phillips, P.A.1    Wu, M.J.2    Kumar, R.K.3
  • 88
    • 30144433678 scopus 로고    scopus 로고
    • Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway
    • Hama K, Ohnishi H, Aoki H, e al. Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway. Biochem Bioph Res Co 2006; 340: 742-50.
    • (2006) Biochem Bioph Res Co , vol.340 , pp. 742-750
    • Hama, K.1    Ohnishi, H.2    Aoki, H.3
  • 89
    • 24144461303 scopus 로고    scopus 로고
    • Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin zeta(5)beta(1) as a novel CCN2 receptor
    • Gao RP, Brigstock DR. Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin zeta(5)beta(1) as a novel CCN2 receptor. Gastroenterology 2005; 129: 1019-30.
    • (2005) Gastroenterology , vol.129 , pp. 1019-1030
    • Gao, R.P.1    Brigstock, D.R.2
  • 90
    • 33845989205 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines
    • Aoki H, Ohnishi H, Hama K, et al. Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines. Am J Physiol-Cell Ph 2007; 292: C259-C68.
    • (2007) Am J Physiol-Cell Ph , vol.292
    • Aoki, H.1    Ohnishi, H.2    Hama, K.3
  • 91
    • 0141869043 scopus 로고    scopus 로고
    • Activin A is an autocrine activator of rat pancreatic stellate cells: Potential therapeutic role of follistatin for pancreatic fibrosis
    • Ohnishi N, Miyata T, Ohnishi H, et al. Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut 2003; 52: 1487-93.
    • (2003) Gut , vol.52 , pp. 1487-1493
    • Ohnishi, N.1    Miyata, T.2    Ohnishi, H.3
  • 92
    • 30644469765 scopus 로고    scopus 로고
    • Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells
    • Masamune A, Satoh M, Kikuta K, Suzuki N, Shimosegawa T. Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells. World J Gastroenterol 2005; 11: 6144-51.
    • (2005) World J Gastroenterol , vol.11 , pp. 6144-6151
    • Masamune, A.1    Satoh, M.2    Kikuta, K.3    Suzuki, N.4    Shimosegawa, T.5
  • 93
    • 0142071047 scopus 로고    scopus 로고
    • Regulation of pancreatic stellate cell function in vitro: Biological and molecular effects of all-trans retinoic acid
    • Jaster R, Hilgendorf I, Fitzner B, e al. Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid. Biochem Pharmacol 2003; 66: 633-41.
    • (2003) Biochem Pharmacol , vol.66 , pp. 633-641
    • Jaster, R.1    Hilgendorf, I.2    Fitzner, B.3
  • 94
    • 79551664194 scopus 로고    scopus 로고
    • Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis
    • Won JH, Zhang Y, Ji BA, Logsdon CD, Yule DI. Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis. Mol Biol Cell 2011; 22: 421-36.
    • (2011) Mol Biol Cell , vol.22 , pp. 421-436
    • Won, J.H.1    Zhang, Y.2    Ji, B.A.3    Logsdon, C.D.4    Yule, D.I.5
  • 95
    • 33747607470 scopus 로고    scopus 로고
    • Battle-scarred pancreas: Role of alcohol and pancreatic stellate cells in pancreatic fibrosis
    • Apte MV, Pirola RC, Wilson JS. Battle-scarred pancreas: Role of alcohol and pancreatic stellate cells in pancreatic fibrosis. J Gastroen Hepatol 2006; 21: S97-S101.
    • (2006) J Gastroen Hepatol , vol.21
    • Apte, M.V.1    Pirola, R.C.2    Wilson, J.S.3
  • 96
    • 74049098550 scopus 로고    scopus 로고
    • Effects of Ethanol and Its Metabolites on Human Pancreatic Stellate Cells
    • Masamune A, Satoh A, Watanabe T, et al. Effects of Ethanol and Its Metabolites on Human Pancreatic Stellate Cells. Digest Dis Sci 2010; 55: 204-11.
    • (2010) Digest Dis Sci , vol.55 , pp. 204-211
    • Masamune, A.1    Satoh, A.2    Watanabe, T.3
  • 97
    • 77950204203 scopus 로고    scopus 로고
    • Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling
    • Schwer CI, Mutschler M, Stoll P, et al. Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Mol Pharmacol 2010; 77: 660-9.
    • (2010) Mol Pharmacol , vol.77 , pp. 660-669
    • Schwer, C.I.1    Mutschler, M.2    Stoll, P.3
  • 99
    • 63849290925 scopus 로고    scopus 로고
    • Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    • Masamune A, Kikuta K, Watanabe T, et al. Fibrinogen induces cytokine and collagen production in pancreatic stellate cells. Gut 2009; 58: 550-9.
    • (2009) Gut , vol.58 , pp. 550-559
    • Masamune, A.1    Kikuta, K.2    Watanabe, T.3
  • 100
    • 0032829703 scopus 로고    scopus 로고
    • Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
    • Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 1999; 155: 1087-95.
    • (1999) Am J Pathol , vol.155 , pp. 1087-1095
    • Haber, P.S.1    Keogh, G.W.2    Apte, M.V.3
  • 101
    • 0037381733 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats
    • Kuno A, Yamada T, Masuda K, et al. Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology 2003; 124: 1010-9.
    • (2003) Gastroenterology , vol.124 , pp. 1010-1019
    • Kuno, A.1    Yamada, T.2    Masuda, K.3
  • 102
    • 10744225478 scopus 로고    scopus 로고
    • Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta1 regulation of pancreatic stellate cellular functions
    • Ohnishi H, Miyata T, Yasuda H, et al. Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta1 regulation of pancreatic stellate cellular functions. J Biol Chem 2004; 279: 8873-8.
    • (2004) J Biol Chem , vol.279 , pp. 8873-8878
    • Ohnishi, H.1    Miyata, T.2    Yasuda, H.3
  • 103
    • 33750922154 scopus 로고    scopus 로고
    • Hydrogen peroxide activates activator protein-1 and mitogen-activated protein kinases in pancreatic stellate cells
    • Kikuta K, Masamune A, Satoh M, Suzuki N, Satoh K, Shimosegawa T. Hydrogen peroxide activates activator protein-1 and mitogen-activated protein kinases in pancreatic stellate cells. Mol Cell Biochem 2006; 291: 11-20.
    • (2006) Mol Cell Biochem , vol.291 , pp. 11-20
    • Kikuta, K.1    Masamune, A.2    Satoh, M.3    Suzuki, N.4    Satoh, K.5    Shimosegawa, T.6
  • 104
    • 3342953752 scopus 로고    scopus 로고
    • A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells
    • Masamune A, Kikuta K, Suzuki N, Satoh M, Satoh K, Shimosegawa T. A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells. J Pharmacol Exp Ther 2004; 310: 520-7.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 520-527
    • Masamune, A.1    Kikuta, K.2    Suzuki, N.3    Satoh, M.4    Satoh, K.5    Shimosegawa, T.6
  • 105
    • 13244279508 scopus 로고    scopus 로고
    • Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells
    • Masamune A, Kikuta K, Satoh M, Suzuki N, Shimosegawa T. Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells. J Pharmacol Exp Ther 2005; 312: 651-8.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 651-658
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Suzuki, N.4    Shimosegawa, T.5
  • 106
    • 20144380437 scopus 로고    scopus 로고
    • Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats
    • Yamada T, Kuno A, Ogawa K, et al. Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. J Pharmacol Exp Ther 2005; 313: 36-45.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 36-45
    • Yamada, T.1    Kuno, A.2    Ogawa, K.3
  • 107
    • 0036082384 scopus 로고    scopus 로고
    • Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells
    • Masamune A, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells. J Pharmacol Exp Ther 2002; 302: 36-42.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 36-42
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Satoh, A.4    Shimosegawa, T.5
  • 108
    • 0036785330 scopus 로고    scopus 로고
    • Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells
    • Jaster R, Sparmann G, Emmrich J, Liebe S. Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut 2002; 51: 579-84.
    • (2002) Gut , vol.51 , pp. 579-584
    • Jaster, R.1    Sparmann, G.2    Emmrich, J.3    Liebe, S.4
  • 109
    • 1542360111 scopus 로고    scopus 로고
    • Pancreatic stellate cell migration: Role of the phosphatidylinositol 3-kinase(PI3- kinase) pathway
    • McCarroll JA, Phillips PA, Kumar RK, et al. Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3- kinase) pathway. Biochem Pharmacol 2004; 67: 1215-25.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1215-1225
    • McCarroll, J.A.1    Phillips, P.A.2    Kumar, R.K.3
  • 110
    • 0037016773 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells
    • Masamune A, Kikuta K, Satoh M, Sakai Y, Satoh A, Shimosegawa T. Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. J Biol Chem 2002; 277: 141-7.
    • (2002) J Biol Chem , vol.277 , pp. 141-147
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Sakai, Y.4    Satoh, A.5    Shimosegawa, T.6
  • 111
    • 26844558173 scopus 로고    scopus 로고
    • Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs
    • Yoshida S, Ujiki M, Ding XZ, et al. Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. Mol Cancer 2005; 4: 27.
    • (2005) Mol Cancer , vol.4 , pp. 27
    • Yoshida, S.1    Ujiki, M.2    Ding, X.Z.3
  • 112
    • 29244444553 scopus 로고    scopus 로고
    • Vitamin A inhibits pancreatic stellate cell activation: Implications for treatment of pancreatic fibrosis
    • McCarroll JA, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte MV. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. Gut 2006; 55: 79-89.
    • (2006) Gut , vol.55 , pp. 79-89
    • McCarroll, J.A.1    Phillips, P.A.2    Santucci, N.3    Pirola, R.C.4    Wilson, J.S.5    Apte, M.V.6
  • 113
    • 33745247375 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
    • Dornhofer N, Spong S, Bennewith K, et al. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 2006; 66: 5816-27.
    • (2006) Cancer Res , vol.66 , pp. 5816-5827
    • Dornhofer, N.1    Spong, S.2    Bennewith, K.3
  • 114
    • 33745078936 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer
    • Aikawa T, Gunn J, Spong SM, Klaus SJ, Korc M. Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther 2006; 5: 1108-16.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1108-1116
    • Aikawa, T.1    Gunn, J.2    Spong, S.M.3    Klaus, S.J.4    Korc, M.5
  • 115
    • 23844489480 scopus 로고    scopus 로고
    • Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling
    • Yoo BM, Yeo M, Oh TY, et al. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas 2005; 30: e71-9.
    • (2005) Pancreas , vol.30
    • Yoo, B.M.1    Yeo, M.2    Oh, T.Y.3
  • 117
    • 34247399552 scopus 로고    scopus 로고
    • Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells
    • Zhang W, Erkan M, Abiatari I, et al. Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells. Cancer Biol Ther 2007; 6: 218-27.
    • (2007) Cancer Biol Ther , vol.6 , pp. 218-227
    • Zhang, W.1    Erkan, M.2    Abiatari, I.3


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