Vitamin A inhibits pancreatic stellate cell activation: Implications for treatment of pancreatic fibrosis

Gut

Volumn 55, Issue 1, 2006, Pages 79-89

  McCarroll, J A ^b   Phillips, P A ^b   Santucci, N ^b   Pirola, R C ^b   Wilson, J S ^b   Apte, M V ^a  

^a LIVERPOOL HOSPITAL   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; FIBRONECTIN; LAMININ; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; RETINOIC ACID; RETINOL; SMOOTH MUSCLE ACTIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG EFFICACY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REACTION TIME; SIGNAL TRANSDUCTION; STELLATE CELL; TIME SERIES ANALYSIS;

ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; ETHANOL; EXTRACELLULAR MATRIX PROTEINS; FIBROSIS; IMMEDIATE-EARLY PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PANCREAS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRETINOIN; VANADATES; VITAMIN A;

EID: 29244444553     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2005.064543     Document Type: Article

References (43)

1. DiMagno EP, Layer P, Clain JE. Chronic pancreatitis. In: Go VLW, DiMagno EP, Gardner JD, et al. The pancreas: biology, pathobiology and disease. New York: Raven Press, 1993:665-706.
2. Apte MV, Haber PS, Applegate TL, et al. Pancreatic stellate cells are activated by proinflammatory cytokines:implications for fibrogenesis. Gut 1999;44:534-41.
3. Apte MV, Phillips PA, Fahmy RG, et al. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 2000;118:780-94.
4. Schneider E, Schmid-Kotsas A, Zhao J, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol Cell Physiol 2001;281:C532-43.
5. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas-identification, isolation, and culture. Gut 1998;43:128-33.
6. Bachem MG, Schneider E, Gross H, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-32.
7. Love JM, Gudas LJ. Vitamin A, differentiation and cancer. Curr Opin Cell Biol 1994;6:825-31.
8. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10:940-54.
9. Ottonello S, Scita G, Mantovani G, et al. Retinol bound to cellular retinol-binding protein is a substrate for cytosolic retinoic acid synthesis. J Biol Chem 1993;268:27133-42.
10. Duester G. Families of retinoid dehydrogenases regulating vitamin A function: Production of visual pigment and retinoic acid. Eur J Biochem 2000;267:4315-24.
11. Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al. Characterization of three rxr genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992;6:329-44.
12. Ohata M, Lin M, Satre M, et al. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis. Am J Physiol 1997;272:G589-96.
13. Jaster R, Hilgendorf I, Fitzner B, et al. Regulation of pancreatic stellate cell function in vitro: Biological and molecular effects of all-trans retinoic acid. Biochem Pharmacol 2003;66:633-41.
14. Wang XD, Liu C, Chung J, et al. Chronic alcohol intake reduces retinoic acid concentration and enhances ap-1 (c-jun and c-fos) expression in rat liver. Hepatology 1998;28:744-50.
15. Deltour L, Ang HL, Duester G. Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. FASEB J 1996;10:1050-7.
16. Han CL, Liao CS, Wu CW, et al. Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family-implications for etiology of fetal alcohol syndrome and alcohol-related diseases. Eur J Biochem 1998;254:25-31.
17. McCarroll JA, Phillips PA, Park S, et al. Pancreatic stellate cell activation by ethanol and acetaldehyde: Is it mediated by the mitogen-activated protein kinase signaling pathway? Pancreas 2003;27:150-60.
18. Masamune A, Kikuta K, Satoh M, et al. Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells. J Pharmacol Exp Ther 2002;302:36-42.
19. Jaster R, Sparmann G, Emmrich J, et al. Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut 2002;51:579-84.
20. Lopez-Ilasaca M. Signaling from g-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. Biochem Pharmacol 1998;56:269-77.
21. Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocrine Rev 2001;22:153-83.
22. Haneda M, Sugimoto T, Kikkawa R. Mitogen-activated protein kinase phosphatase: A negative regulator of the mitogen-activated protein kinase cascade. Eur J Pharmacol 1999;365:1-7.
23. Sun H, Charles CH, Lau LF, et al. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 1993;75:487-93.
24. Franklin CC, Srikanth S, Kraft AS. Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc Natl Acad Sci U S A 1998;95:3014-19.
25. Chung J, Chavez PR, Russell RM, et al. Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats. Oncogene 2002;21:1539-47.
26. Sauvant P, Sapin V, Abergel A, et al. Pav-1, a new rat hepatic stellate cell line converts retinol into retinoic acid, a process altered by ethanol. Int J Biochem Cell Biol 2002;34:1017-29.
27. Ulven SM, Natarajan V, Holven KB, et al. Expression of retinoic acid receptor and retinoid × receptor subtypes in rat liver cells: Implications for retinoid signalling in parenchymal, endothelial, kupffer and stellate cells. Eur J Cell Biol 1998;77:111-16.
28. McCarroll JA, Phillips PA, Kumar RK, et al. Pancreatic stellate cell migration: Role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway. Biochem Pharmacol 2004;67:1215-25.
29. Lugea A, Gukovsky I, Gukovskaya AS, et al. Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Gastroenterology 2003;125:1845-59.
30. Reif S, Lang A, Lindquist JN, et al. The role of focal adhesion kinase-phosphatiaylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 2003;278:8083-90.
31. Xu Q, Konta T, Furusu A, et al. Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect. J Biol Chem 2002;277:41693-700.
32. Lee HY, Sueoka N, Hong WK, et al. All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. Mol Cell Biol 1999;19:1973-80.
33. Snedecor G, Cochran W. Statistical methods, 8th edn., Ames, IO: Iowa State University Press 1989.
34. Feldman DJ, Hofmann R, Gagnon J, et al. Statview ii. Berkeley, CA: Abacus Concepts Inc, 1987.
35. Palm-Leis A, Singh US, Herbelin BS, et al. Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes. J Biol Chem 2004;279:54901-17.
36. Masamune A, Satoh M, Kikuta K, et al. Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells. J Pharmacol Exp Ther 2003;304:8-14.
37. Masamune A, Kikuta K, Suzuki N, et al. A c-jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-CD]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells. J Pharmacol Exp Ther 2004;310:520-7.
38. Lee HY, Walsh GL, Dawson MI, et al. All-trans-retinoic acid inhibits Jun N-terminal kinase-dependent signaling pathways. J Biol Chem 1998;273:7066-71.
39. Karin M, Liu Z, Zandi E. Ap-1 function and regulation. Curr Opin Cell Biol 1997;9:240-6.
40. Chiu R, Boyle WJ, Meek J, et al. The c-fos protein interacts with c-jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 1988;54:541-52.
41. Schule R, Rangarajan P, Yang N, et al. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci U S A 1991;88:6092-6.
42. Lee JC, Kassis S, Kumar S, et al. P38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol Ther 1999;82:389-97.
43. Molotkov A, Duester G. Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase. J Biol Chem 2002;277:22553-7.