Expression of transforming growth factor-β1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis

American Journal of Pathology

Volumn 160, Issue 5, 2002, Pages 1787-1798

  Shek, Fanny Wai Tsing ^a   Benyon, Robert Christopher ^a   Walker, Fiona Mairi ^a   McCrudden, Peter Raymond ^a   Pender, Sylvia Lin Foon ^a   Williams, Elizabeth Jean ^a   Johnson, Penelope Ann ^a   Johnson, Colin David ^a   Bateman, Adrian Calvin ^a   Fine, David Roger ^a   Iredale, John Peter ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MESSENGER RNA; NEUTRALIZING ANTIBODY; PROCOLLAGEN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHRONIC PANCREATITIS; COLLAGEN DEGRADATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; FIBROGENESIS; FIBROSIS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; NONHUMAN; NORTHERN BLOTTING; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; REGULATORY MECHANISM; STELLATE CELL; WESTERN BLOTTING;

EID: 0036098613     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61125-X     Document Type: Article

References (43)

1. Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
2. Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture
3. Identification, culture, and characterization of pancreatic stellate cells in rats and humans
4. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies
5. Collagenases and liver fibrosis
6. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen
7. Metalloproteinases and their inhibitors in liver fibrosis
8. The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase
9. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity
10. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
11. Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo
12. Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats
13. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
14. Fibrocytes and fibroblasts. Definition and significance in wound healing and fibrotic diseases of the skin
15. Transforming growth factor beta in tissue fibrosis
16. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors
17. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
18. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor
19. Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts
20. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression
21. Hepatic fibrogenesis: The puzzle of interacting cells, fibrogenic cytokines, regulatory loops, and extracellular matrix molecules
22. Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis
23. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
24. TGF-beta 1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro
25. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues
26. Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
27. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver
28. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver
29. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
30. Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP)
31. The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
32. Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling
33. Immunohistochemical study of transforming growth factor-beta 1, matrix metalloproteinase-2,9, tissue inhibitors of metalloproteinase-1,2, and basement membrane components at pancreatic ducts in chronic pancreatitis
34. The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases
35. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells
36. Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis
37. Angiotensin II-induced modulation of rat mesangial cell phenotype
38. Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation
39. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
40. Enhancement of transforming growth factor beta 1 expression in the rat pancreas during regeneration from caerulein-induced pancreatitis
41. Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis
42. Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis
43. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells