Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas

Surgery

Volumn 131, Issue 2, 2002, Pages 129-134

  Yen, Tina W F ^a   Aardal, Nils Petter ^a   Bronner, Mary P ^a   Thorning, David R ^a   Savard, Christopher E ^a   Lee, Sum P ^a   Bell Jr, Richard H ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; COLLAGEN TYPE 4; MYOSIN HEAVY CHAIN; PROCOLLAGEN; VON WILLEBRAND FACTOR;

ARTICLE; CELL TYPE; CLINICAL ARTICLE; CYSTIC FIBROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MYOFIBROBLAST; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; PANCREAS ISLET CELL TUMOR; PANCREATICODUODENECTOMY; PRIORITY JOURNAL; STELLATE CELL;

EID: 0036186862     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1067/msy.2002.119192     Document Type: Article

References (37)

1. Fine structure of human pancreatic adenocarcinoma
2. Pathomorphology of ductal pancreatic cancer
3. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers
4. Myofibroblasts in hepatitis B related cirrhosis and hepatocellular carcinoma
5. α-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma
6. Evidence that "myofibroblast-like" cells are the cellular source of capsular collagen in hepatocellular carcinoma
7. Myofibroblasts and hepatocellular carcinoma: An in vivo and in vitro study
8. Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: An in vivo and in vitro study
9. Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture
10. Identification, culture, and characterization of pancreatic stellate cells in rats and humans
11. Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
12. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
13. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells
14. Repetitive acute pancreatic injury in the mouse induces procollagen α1(I) expression colocalized to pancreatic stellate cells
15. Microwave based antigenic unmasking: A revolutionary new technique for routine immunohistochemistry
16. Induction of smooth muscle cells in the fibrous capsule of human hepatocellular carcinoma but not in the septa of hepatic cirrhosis
17. Distribution of type IV collagen in pancreatic adenocarcinoma and chronic pancreatitis
18. Immunohistochemical staining for type IV collagen and laminin in the stroma of human pancreatic cancer
19. Altered expression of extracellular matrix molecules and their receptors in chronic pancreatitis and pancreatic adenocarcinoma in comparison with normal pancreas
20. Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and c-fibronectin in cultured pancreatic stellate cells
21. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implications in pathogenesis of pancreas fibrosis
22. Activation of cultured rat hepatic stellate cells by tumoral hepatocytes
23. Transforming growth factor β responsiveness is modulated by the extracellular collagen matrix during hepatic Ito cell culture
24. Differential effects of interleukin-1α, tumor necrosis factor α, and transforming growth factor β1 on cell proliferation and collagen formation by cultured fat-storing cells
25. Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells
26. Transforming growth factor β1-regulated gene expression of Ito cells
27. Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-β1
28. Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival
29. Expression of transforming growth factor β1 (TGFβ1) and its receptors in pancreatic duct cell carcinoma and in chronic pancreatitis
30. Transforming growth factor β promotes development of fibrosis after repeated courses of acute pancreatitis in mice
31. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver
32. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen
33. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes: Analysis of gene expression, protein synthesis and proteinase activity
34. Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture
35. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1: Implications for regulation of matrix degradation in liver
36. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
37. Expression of tissue inhibitor of metalloproteinases-1 and -2 is increased in fibrotic human liver