Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

Gut

Volumn 51, Issue 4, 2002, Pages 579-584

  Jaster, R ^a   Sparmann, G ^a   Emmrich, J ^a   Liebe, S ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; TRAPIDIL;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPHORESIS; IMMUNOBLOTTING; MITOGENESIS; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; IMMUNOBLOTTING; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PANCREAS; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RATS, INBRED LEW; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRAPIDIL;

EID: 0036785330     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.51.4.579     Document Type: Article

References (47)

1. Longnecker DS. Pathology and pathogenesis of diseases of the pancreas. Am J Pathol 1983;107:103-21.
2. Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification and new genetic developments. Gastroenterology 2001;120:682-707.
3. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998;43:128-33.
4. Bachem MG, Schneider E, Groß H, et al. Identification, culture, and characterisation of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-3.
5. Gressner AM, Bachem MG. Molecular mechanisms of liver fibrogenesis - a homage to the role of activated fat-storing cells. Digestion 1995;56:335-46.
6. Friedman SD. The cellular basis of hepatic fibrosis. N Engl J Med 1993;328:1828-35
7. Gressner AM. Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J Hepatol 1995;22:28-36.
8. Brenner DA, Waterboer T, Choi SK, et al. New aspects of hepatic fibrosis. J Hepatol 2000;32:32-8.
9. Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999;44:534-41.
10. Wells RG, Crawford JM. Pancreatic stellate cells: The new stars of chronic pancreatitis? Gastroenterology 1998;115:491-3.
11. Haber PS, Kegh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 1999;155:1087-95.
12. Kruse M-L, Hildebrand PB, Timke C, et al. TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul Peptides 2000;90:47-52.
13. Luttenberger T, Schmid-Kotsas A, Menke A, et al. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest 2000;80:47-55.
14. ten Dijke P, Miyazone K, Heldin C-H. Signaling inputs converge on nuclear effectors in TGF-β signaling. TIBS 2000;25:64-70.
15. Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell 1998;95:737-40.
16. Claesson-Welsh L. Platelet-derived growth factor receptor signals. J Biol Chem 1994;269:32023-6.
17. Heldin C-H. Dimerization of cell surface receptors in signal transduction. Cell 1995;80:212-23.
18. Marra F, Arrighi MC, Fazi M, et al. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 1999;30:951-8.
19. Marra F, Gentilini A, Pinzani M, et al. Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells. Gastroenterology 1997;112:1297-306.
20. Marra F, Pinzani M, DeFranco R, et al. Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells. FEBS Letters 1995;376:141-5.
21. Carloni V, Pinzani M, Giusti S, et al. Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells. Hepatology 2000;31:131-40.
22. Lewis TS, Shapiro PS, Ahn SG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139.
23. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
24. Gille H, Kortenjann M, Thomae O, et al. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 1995, 14:951-62.
25. Wasylyk B, Hahn SJ, Giovane A. The Ets family of transcription factors. Eur J Biochem 1993;211:7-18.
26. Karin M, Liu Zg, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 1997;9:240-6.
27. Ip YT, Davis RJ. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr Opin Cell Biol 1998;10:205-19.
28. Lowry OH, Rosebrough NJ, Farr AT, et al. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
29. Jaster R, Tschirch E, Bittorf T, et al. Interferon-alpha inhibits proliferation of Ba/F3 cells by interfering with interleukin-3 action. Cell Signal 1999;10:769-75.
30. Bittorf T, Jaster R, Brock J. Rapid activation of the MAP kinase pathway in hematopoietic cells by erythropoietin, granulocyte-macrophage colony-stimulating factor and interleukin-3. Cell Signal 1994;6:305-11.
31. Welham MJ, Duronio V, Sanghera JS, et al. Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family. J Immunol 1992;149:1683-93.
32. Gesualdo L, Di Paolo E, Ranieri E, et al. Trapidil inhibits human mesangial cell proliferation: effect on PDGF β-receptor binding and expression. Kidney Int 1994;40:1002-9.
33. Knorr M, Denk PO. Inhibitory effect of Trapidil on the proliferation of bovine corneal fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol 1999;237:72-7.
34. Voisard R, Hanke H, Baur R, et al. High dose trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, inhibits proliferative activity of human coronary plaque cells in vitro. Perfusion 1997;6:201-6.
35. Razzaque MS, Cheng M, Tagushi T. Suppression of mesangial cell proliferation by Trapidil in glomerulonephritis induced by anti-thymocyte serum in rat. J Int Med Res 1995;23:458-66.
36. Bönisch D, Weber A-A, Wittpoth M, et al. Antimitogenic effects of trapidil in coronary artery smooth muscle cells by direct activation of protein kinase A. Mol Pharmacol 1998;54:241-8.
37. Kuratso JI, Ushio Y. Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro. J Neurosurg 1990;73:436-40.
38. Hoshiya M, Midori A. Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade. Hypertension 1998;31:664-71.
39. Alessi DR, Cuenda A, Cohen P, et al. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995;270:27489-94.
40. Apte MV, Phillips PA, Fahmy RG, et al. Does alcohol directly stimulate pancreatic fibrogenesis? Gastroenterology 2000;118:780-94.
41. Dooley S, Delvoux B, Lahme B, et al. Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatotogy 2000;31:1094-106.
42. Bissell DM, Wang SS, Jarnagin WR, et al. Cell-specific expression of transforming growth factor-beta in rat liver - evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 1995;96:447-55.
43. Milani S, Herbst H, Schuppan D, et al. Transforming growth factors-beta1 and -beta2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991;139:1221-9.
44. Noguchi K, Tomoike H, Kawachi Y, et al. Effects of Trapidil and nitroglycerin on coronary circulation in conscious dogs. Arzneimittelforschung 1984;34:872-6.
45. Nishikawa H, Ono N, Motoyasu M. Preventive effects of trapidil (PDGF antagonist) on restenosis after PTCA. Circulation 1992;86:1-53.
46. Bartel S, Tenor H, Krause EG. Trapidil derivates are potent inhibitors of cyclic AMP phosphodiesterase from heart and coronary arteries. Biomed Biochim Acta 1985;44:K31-5.
47. Sparmann G, Merkord J, Jäschke A, et al. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology 1997;112:1664-72.