Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14631-14643

  Ono, Kenjiro ^a   Li, Lei ^b   Takamura, Yusaku ^c   Yoshiike, Yuji ^d   Zhu, Lijun ^b   Han, Fang ^b   Mao, Xian ^b   Ikeda, Tokuhei ^a   Takasaki, Jun Ichi ^a   Nishijo, Hisao ^c   Takashima, Akihiko ^d   Teplow, David B ^e   Zagorski, Michael G ^b   Yamada, Masahito ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY OF TOYAMA   (Japan)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION PROCESS; ALZHEIMER DISEASE; ASSEMBLY PROCESS; CELLULAR TOXICITIES; IN-VITRO; INVARIANT FEATURES; MYRICETIN; PHENOLIC COMPOUNDS; ROSMARINIC ACID; SHIFT CHANGES; SITE-SPECIFIC;

AGGLOMERATION; GLYCOPROTEINS; OLIGOMERIZATION; OLIGOMERS; TOXICITY;

PHENOLS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; MYRICETIN; PHENOL; ROSMARINIC ACID; TETRAMER;

ALZHEIMER DISEASE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CROSS LINKING; DRUG CYTOTOXICITY; DRUG STRUCTURE; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; FOOD INTAKE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NEUROFILAMENT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SYNAPTIC INHIBITION;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; CINNAMATES; DEPSIDES; FLAVONOIDS; HEK293 CELLS; HUMANS; MICE; PROTEIN MULTIMERIZATION; SYNAPSES;

EID: 84860386735     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.325456     Document Type: Article

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