Drug target validation of the trypanothione pathway enzymes through metabolic modelling

FEBS Journal

Volumn 279, Issue 10, 2012, Pages 1811-1833

  Olin Sandoval, Viridiana ^a   González Chávez, Zabdi ^a   Berzunza Cruz, Miriam ^b   Martínez, Ignacio ^c   Jasso Chávez, Ricardo ^a   Becker, Ingeborg ^b   Espinoza, Bertha ^c   Moreno Sánchez, Rafael ^a   Saavedra, Emma ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

control coefficient; drug targeting; kinetic modelling; metabolic control analysis; oxidative stress

Indexed keywords

ANTIOXIDANT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE SYNTHASE; SPERMIDINE; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; TRYPANOSOMA CRUZI;

AMIDE SYNTHASES; ANTIOXIDANTS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; KINETICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NADH, NADPH OXIDOREDUCTASES; PROTOZOAN PROTEINS; SIGNAL TRANSDUCTION; SPERMIDINE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 84860345158     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08557.x     Document Type: Article

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