Gene knockdown of γ-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme

Journal of Biological Chemistry

Volumn 278, Issue 41, 2003, Pages 39794-39800

  Huynh, Tu T ^c   Huynh, Van T ^c   Harmon, Margaret A ^a   Phillips, Margaret A ^b  

^a Science Media   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; GENES; RNA; TOXICITY;

CYTOTOXIC AGENTS;

ENZYMES;

ADENOSYLMETHIONINE DECARBOXYLASE; BUTHIONINE SULFOXIMINE; CYTOTOXIC AGENT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; ORNITHINE DECARBOXYLASE; PEPTIDE; RNA; SPERMIDINE; TETRACYCLINE; THIOL; TRYPANOTHIONE;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; CELL LINE; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; KNOCKOUT GENE; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; TRYPANOSOMA BRUCEI; WILD TYPE;

ANIMALS; BASE SEQUENCE; BUTHIONINE SULFOXIMINE; CELL DEATH; DNA, PROTOZOAN; ENZYME INHIBITORS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; RNA INTERFERENCE; SPERMIDINE; SULFHYDRYL COMPOUNDS; TRYPANOSOMA BRUCEI BRUCEI;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0141994807     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306306200     Document Type: Article

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