Information transfer in metabolic pathways: Effects of irreversible steps in computer models

European Journal of Biochemistry

Volumn 268, Issue 24, 2001, Pages 6616-6624

  Cornish Bowden, Athel ^a   Cárdenas, María Luz ^a  

^a CNRS   (France)

Author keywords

Feedback inhibition; Metabolic modelling; Reversibility; Steady state

Indexed keywords

PYRUVATE KINASE;

ARTICLE; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; FEEDBACK SYSTEM; METABOLISM; METABOLITE; MOLECULAR MODEL; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; COMPUTER SIMULATION; FEEDBACK; KINETICS; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0035667360     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02616.x     Document Type: Article

References (33)

1. Metabolic control mechanisms VII. A detailed computer model of the glycolytic pathway in ascites cells
2. MetaModel: A program for modelling and control analysis of metabolic pathways on the IBM PC and compatibles
3. SCAMP: A general-purpose simulator and metabolic control analysis program
4. GEPASI: A software package for modelling the dynamics, steady states and control of biochemical and other systems
5. JARNAC: A system for interactive metabolic analysis
6. Isotope exchange evidence for an ordered mechanism for rat-liver glucokinase, a monomeric co-operative enzyme
7. Linear theory of enzymatic chains; its application for the analysis of the crossover theorem and of the glycolysis of human erythrocytes
8. A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
9. Metabolic dynamics in the human red cell. Part III - Metabolic reaction rates
10. Compartmentalized glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes
11. What controls glycolysis in bloodstream form Trypanosoma brucei?
12. Use of mathematical models for predicting the metabolic effect of large-scale enzyme activity alterations. Application to enzyme deficiencies of red blood cells
13. Model of 2,3-bisphos-phoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: Equations and parameter treatment
14. A modelling study of feedforward activation in human erythrocyte glycolysis
15. Prospects for antiparasitic drugs: The case of Trypanosoma brucei, the causative agent of African sleeping sickness
16. Metabolic modeling identifies key constraints on an engineered glycine betaine synthesis pathway in tobacco
17. Irreversible reactions in metabolic simulations: How reversible is irreversible?
18. Control analysis of mammalian serine biosynthesis
19. 'Slave' metabolites and enzymes: A rapid way of delineating metabolic control
20. The reversible Hill equation: How to incorporate cooperative enzymes into metabolic models
21. Quantitative assessment of regulation in metabolic systems
22. Regulating the cellular economy of supply and demand
23. Activation of nitrite reductase from Escherichia coli K12 by oxidized nicotinamide-adenine dinucleotide
24. 1 compounds, alcohols, sugars and acetate in the methane oxidizing bacterium Methylococcus capsulatus
25. Metabolic control and its analysis: Additional relationships between elasticities and control coeffi-cients
26. Compartmentation protects trypanosomes from the dangerous design of glycolysis
27. A mathematical model of the Calvin photosynthesis cycle
28. Modelling photosynthesis and its control