Polyamine metabolism in Trypanosoma cruzi: Studies on the expression and regulation of heterologous genes involved in polyamine biosynthesis

Amino Acids

Volumn 38, Issue 2, 2010, Pages 645-651

  Algranati, I D ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

Author keywords

DFMO resistance; Gene expression; Polyamine auxotrophy; Post translational processing; Transgenic parasites; Trypanosoma cruzi

Indexed keywords

ARGININE DECARBOXYLASE; EFLORNITHINE; GENOMIC DNA; MESSENGER RNA; ORNITHINE DECARBOXYLASE; POLYAMINE; PROTOZOAL PROTEIN;

CELL COMPARTMENTALIZATION; CELL PROLIFERATION; CONFERENCE PAPER; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC STABILITY; HETEROLOGOUS EXPRESSION; METABOLIC REGULATION; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; POLYAMINE METABOLISM; POLYAMINE SYNTHESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PROCESSING; SENSITIVITY AND SPECIFICITY; TRYPANOSOMA CRUZI; ANIMAL; BIOSYNTHESIS; CHAGAS DISEASE; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PARASITOLOGY; REVIEW;

EUKARYOTA; TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

ANIMALS; BIOSYNTHETIC PATHWAYS; CHAGAS DISEASE; GENE EXPRESSION REGULATION; HUMANS; POLYAMINES; PROTOZOAN PROTEINS; TRYPANOSOMA CRUZI;

EID: 77953064754     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0425-6     Document Type: Conference Paper

References (53)

1. Algranati ID, Sánchez C, González NS (1990) Polyamines in Tripanosoma cruzi and Leishmania mexicana. In: Goldemberg SH, Algranati ID (eds) The biology and chemistry of polyamines. Oxford University Press, Oxford, pp 137-146
2. Ariyanayagam MR, Fairlamb AH (1997) Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes. Mol Biochem Parasitol 84:111-121
3. Bacchi CJ, Marcus SL, Lambros C, Goldberg B, Messina L, Hutner SH (1974) Unsubstituted agarose as an affinity matrix for isolation of NAD-dependent alpha-glycerophosphate dehydrogenase from the trypanosomatid Crithidia fasciculate. Biochem Biophys Res Commun 58:778-786
4. Bacchi CJ, Braunstein VL, Rattendi D, Yarlett N, Wittner M, Tanowitz HB (2001) Stage-specific polyamine metabolism in Trypanosoma cruzi. J Eukaryot Microbiol 201S-202S
5. Bell E, Malmberg RL (1990) Analysis of a cDNA encoding arginine decarboxylase from oat reveals similarity to the Escherichia coli arginine decarboxylase and evidence of protein processing. Mol Gen Genet 224:431-436
6. Borst P, Ouellette M (1995) New mechanisms of drug resistance in parasitic protozoa. Annu Rev Microbiol 49:427-460
7. Carrillo C, Cejas S, González NS, Algranati ID (1999) Trypanosoma cruzi epimastigotes lack ornithine decarboxylase but can express a foreign gene encoding this enzyme. FEBS Lett 454:192-196
8. Carrillo C, Cejas S, Huber A, González NS, Algranati ID (2003) Lack of arginine decarboxylase in Trypanosoma cruzi epimastigotes. J Eukaryot Microbiol 50:312-316
9. Carrillo C, Serra MP, Pereira CA, Huber A, González NS, Algranati ID (2004) Heterologous expression of a plant arginine decarboxylase gene in Trypanosoma cruzi. Biochim Biophys Acta 1674:223-230
10. Carrillo C, Cánepa GE, Algranati ID, Pereira CA (2006) Molecular and functional characterization of a spermidine transporter (TcPAT12) from Trypanosoma cruzi. Biochem Biophys Res Común 344:936-940
11. Carrillo C, González NS, Algranati ID (2007) Tripanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites. Biochim Biophys Acta 1770:1605-1611
12. Cazzulo JJ, Cazzulo Franke MC, Martínez J, Franke de Cazzulo BM (1990) Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi. Biochim Biophys Acta 1037:186-191
13. Clayton CE (2002) Life without transcriptional control? From fly to man and back again. EMBO J 21:1881-1888
14. Cohen SS (1998) Biosynthesis and metabolism of diamines in bacteria. In: Cohen SS (ed) A guide to the polyamines. Oxford University Press, Oxford, pp 122-141
15. Cook T, Roos D, Morada M, Zhu G, Keithly JS, Feagin JE, Wu G, Yarlett N (2007) Divergent polyamine metabolism in the apicomplexa. Microbiology 153:1123-1130
16. Cronin CN, Nolan DP, Voorheis HP (1989) The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei. FEBS Lett 244:26-30
17. Fairlamb AH (1989) Novel biochemical pathways in parasitic protozoa. Parasitology 99: S93-S112
18. Fairlamb AH (2002) Metabolic pathway analysis in trypanosomes and malaria parasites. Phil Trans R Soc Lond B 357:101-107
19. Fairlamb AH, Cerami A (1985) Identification of a novel, thiolcontaining cofactor essential for glutathione reductase enzyme activity in trypanosomatids. Mol Biochem Parasitol 14:187-198
20. Fairlamb AH, Cerami A (1992) Metabolism and functions of trypanothione in the kinetoplastida. Annu Rev Microbiol 46:695-729
21. Fairlamb AH, Blackburn P, Ulrich P, Chait BT, Cerami A (1985) Tripanothione: a novel bis (glutathionyl) spermidine cofactor for glutathione reductase in trypanosomatids. Science 227:1485-1487
22. González NS, Ceriani C, Algranati ID (1992) Differential regulation of putrescine uptake in Trypanosoma cruzi and other tripanosomatids. Biochem Biophys Res Commun 188:120-128
23. González NS, Ceriani C, Algranati ID (1993) Transporte de poliaminas en tripanosomátidos. An Asoc Quím Arg 81:117-125
24. González NS, Huber A, Algranati ID (2001) Spermidine is essential for normal proliferation of trypanosomatid protozoa. FEBS Lett 508:323-326
25. Hanfrey C, Sommer S, Mayer MJ, Burtin D, Michael AJ (2001) Arabidopsis polyamine biosynthesis: absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity. Plant J 27:551-560
26. Heby O, Emanuelsson H (1981) Role of the polyamines in germ cell differentiation and in early embryonic development. Med Biol 59:417-422
27. Heby O, Persson L, Rentala M (2007) Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease and Leishmaniasis. Amino Acids 33:359-366
28. Hernández S, Schwarcs de Tarlovsky M (1999) Arginine decarboxylase in Trypanosoma cruzi. Characteristics and kinetic properties. Cell Mol Biol 45:383-391
29. Kahana C (2007) Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines. Amino Acids 33:225-230
30. Kelly JM, Ward HM, Miles MA, Kendall G (1992) A shuttle vector which facilitates the expression of transfected genes in Trypanosoma cruzi and Leishmania. Nucleic Acids Res 20:3963-3969
31. Kierszenbaum F, Wirth JJ, McCann PP, Sjoerdsma A (1987) Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells. Proc Natl Acad Sci USA 84:4278-4282
32. Klaus SM, Kunji ER, Bozzo GG, Noiriel A, de la Garza RD, Basset GJ, Ravanel S, Rébeillé F, Gregory JF 3rd, Hanson AD (2005) Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids. J Biol Chem 280:38457-38463
33. Kohl L, Robinson D, Bastin P (2003) Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes. EMBO J 22:5336-5346
34. Majunder S, Wirth JJ, Bitonti AJ, McCann PP, Kierszenbaum F (1992) Biochemical evidence for the presence of arginine decarboxylase activity in Trypanosoma cruzi. J Parasitol 78:371-374
35. Malmberg RL, Cellino ML (1994) Arginine decarboxylase of oats is activated by enzymatic cleavage into two polypeptides. J Biol Chem 269:2703-2706
36. Marr JJ, Berens RL (1983) Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae. Mol Biochem Parasitol 7:339-356
37. Martínez Calvillo S, López I, Hernández R (1997) pRIBOTEX expresión vector: a pTEX derivative for rapid selection of Tripanosoma cruzi transfectants. Gene 199:71-76
38. Müller S, Coombs GH, Walter RD (2001) Targeting polyamines of parasitic protozoa in chemotherapy. Trends Parasitol 17:242-249
39. Opperdoes FR, Coombs GH (2007) Metabolism of Leishmania; proven and predicted. Trends Parasitol 23:149-158
40. Opperdoes FR, Michels PA (2001) Enzymes of carbohydrate metabolism as potential drug targets. Int J Parasitol 31:482-490
41. Ouellette M, Drummelsmith J, El-Fadili A, Kündig C, Richard D, Roy G (2002) Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. Int J Parasitol 32:385-398
42. Pegg AE (1988) Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 48:759-774
43. Serra MP, Carrillo C, González NS, Algranati ID (2006) Modulation of oat arginine decarboxylase gene expression and genome organization in transgenic Trypanosoma cruzi epimastigotes. FEBS J 273:628-637
44. Serra MP, Senn A, Algranati ID (2009) Post-translational processing, metabolic stability and catalytic efficiency of oat arginine decarboxylase expressed in Trypanosoma cruzi epimastigotes. Exp Parasitol 122:169-176
45. Smith TA, Marshall J H A (1988) The oxidative decarboxylation of ornithine by extracts of higher plants. Phytochemistry 27:710-793
46. Steglich C, Schaeffer SW (2006) The ornithine decarboxylase gene of Trypanosoma brucei: evidence for horizontal gene transfer from a vertebrate source. Infect Genet Evolut 6:205-219
47. Svensson F, Ceriani C, Lövkvist Wallström E, Kockum I, Algranati ID, Heby O, Persson L (1997) Cloning of a trypanosomatid gene coding for an ornithine decarboxylase that is metabolically unstable even though it lacks the C-terminal degradation domain. Proc Natl Acad Sci USA 94:397-402
48. Tyler KM, Engman DM (2001) The life cycle of Trypanosoma cruzi revisited. Int J Parasitol 31:472-481
49. van Hellemond JJ, Tielens AG (1997) Inhibition of the respiratory chain results in a reversible metabolic arrest in Leishmania promastigotes. Mol Biochem Parasitol 85:135-138
50. Vickerman K (1985) Developmental cycles and biology of pathogenic trypanosomes. Br Med Bull 41:105-114
51. Wallace HM, Fraser AV, Hughes A (2003) A perspective of polyamine metabolism. Biochem J 376:1-14
52. Yakubu MA, Basso B, Kierszenbaum F (1992) DL-α difluoromethy- larginine inhibits intracellular Trypanosoma cruzi multiplication by affecting cell division but not trypomastigote-amastigote transformation. J Parasitol 78:414-419
53. Yoshida N, Camargo EP (1978) Ureotelism and ammonotelism in trypanosomatids. J Bacteriol 136:1184-1186