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Volumn 31, Issue 20, 2003, Pages 5886-5896

Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSYLHOMOCYSTEINASE; ANTIBIOTIC AGENT; ANTIMONY; ARSENIC TRIOXIDE; CARRIER PROTEIN; CELL DNA; DIHYDROFOLATE REDUCTASE; DNA FRAGMENT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE SYNTHASE; METHIONINE ADENOSYLTRANSFERASE; METHOTREXATE; OXIDOREDUCTASE; PTERIDINE; RNA;

EID: 10744222969     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg806     Document Type: Article
Times cited : (111)

References (56)
  • 1
    • 0033517487 scopus 로고    scopus 로고
    • Leishmaniasis
    • Herwaldt,B.L. (1999) Leishmaniasis. Lancet, 354, 1191-1199.
    • (1999) Lancet , vol.354 , pp. 1191-1199
    • Herwaldt, B.L.1
  • 3
    • 0034451615 scopus 로고    scopus 로고
    • Failure of pentavalent antimony in visceral leishmaniasis in India: Report from the Center of the Indian Epidemic
    • Sundar,S., More,D.K., Singh,M.K., Singh,V.P., Sharma,S., Makharia,A., Kumar,P.C. and Murray,H.W. (2000) Failure of pentavalent antimony in visceral leishmaniasis in India: report from the Center of the Indian Epidemic. Clin. Infect. Dis., 31, 1104-1107.
    • (2000) Clin. Infect. Dis. , vol.31 , pp. 1104-1107
    • Sundar, S.1    More, D.K.2    Singh, M.K.3    Singh, V.P.4    Sharma, S.5    Makharia, A.6    Kumar, P.C.7    Murray, H.W.8
  • 4
    • 0141989320 scopus 로고    scopus 로고
    • Drug resistance in parasites
    • Marr,J., Nielsen,T. and Komuniecki,R. (eds), Academic Press, San Diego
    • Ouellette,M. and Ward,S. (2002) Drug resistance in parasites. In Marr,J., Nielsen,T. and Komuniecki,R. (eds), Molecular Medical Parasitology. Academic Press, San Diego, pp. 395-430.
    • (2002) Molecular Medical Parasitology , pp. 395-430
    • Ouellette, M.1    Ward, S.2
  • 5
    • 0035830909 scopus 로고    scopus 로고
    • Novel intracellular SbV reducing activity correlates with antimony susceptibility in Leishmania donovani
    • Shaked-Mishan,P., Ulrich,N., Ephros,M. and Zilberstein,D. (2001) Novel intracellular SbV reducing activity correlates with antimony susceptibility in Leishmania donovani. J. Biol. Chem., 276, 3971-3976.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3971-3976
    • Shaked-Mishan, P.1    Ulrich, N.2    Ephros, M.3    Zilberstein, D.4
  • 6
    • 0141994732 scopus 로고    scopus 로고
    • Antimony uptake systems in the protozoan parasite Leishmania and accumulation alteration in antimony resistant parasites
    • in press
    • Brochu,C., Wang,J., Roy,G., Messier,N., Wang,X.Y., Saravia,N.G. and Ouellette,M. (2003) Antimony uptake systems in the protozoan parasite Leishmania and accumulation alteration in antimony resistant parasites. Antimicrob. Agents Chemother., in press.
    • (2003) Antimicrob. Agents Chemother.
    • Brochu, C.1    Wang, J.2    Roy, G.3    Messier, N.4    Wang, X.Y.5    Saravia, N.G.6    Ouellette, M.7
  • 8
    • 0034732687 scopus 로고    scopus 로고
    • Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae
    • Haimeur,A., Brochu,C., Genest,P., Papadopoulou,B. and Ouellette,M. (2000) Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae. Mol. Biochem. Parasitol., 108, 131-135.
    • (2000) Mol. Biochem. Parasitol. , vol.108 , pp. 131-135
    • Haimeur, A.1    Brochu, C.2    Genest, P.3    Papadopoulou, B.4    Ouellette, M.5
  • 9
    • 0026793462 scopus 로고
    • Metabolism and functions of trypanothione in the Kinetoplastida
    • Fairlamb,A.H. and Cerami,A. (1992) Metabolism and functions of trypanothione in the Kinetoplastida. Annu. Rev. Microbiol., 46, 695-729.
    • (1992) Annu. Rev. Microbiol. , vol.46 , pp. 695-729
    • Fairlamb, A.H.1    Cerami, A.2
  • 10
    • 0030924243 scopus 로고    scopus 로고
    • Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene PGPA in arsenite-resistant Leishmania tarentolae
    • Grondin,K., Haimeur,A., Mukhopadhyay,R., Rosen,B.P. and Ouellette,M. (1997) Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene PGPA in arsenite-resistant Leishmania tarentolae. EMBO J., 16, 3057-3065.
    • (1997) EMBO J. , vol.16 , pp. 3057-3065
    • Grondin, K.1    Haimeur, A.2    Mukhopadhyay, R.3    Rosen, B.P.4    Ouellette, M.5
  • 11
    • 0032744407 scopus 로고    scopus 로고
    • Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania
    • Haimeur,A., Guimond,C., Pilote,S., Mukhopadhyay,R., Rosen,B.P., Poulin,R. and Ouellette,M. (1999) Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania. Mol. Microbiol., 34, 726-735.
    • (1999) Mol. Microbiol. , vol.34 , pp. 726-735
    • Haimeur, A.1    Guimond, C.2    Pilote, S.3    Mukhopadhyay, R.4    Rosen, B.P.5    Poulin, R.6    Ouellette, M.7
  • 13
    • 0031861799 scopus 로고    scopus 로고
    • Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate
    • Haimeur,A. and Ouellette,M. (1998) Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate. Antimicrob. Agents Chemother., 42, 1689-1694.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1689-1694
    • Haimeur, A.1    Ouellette, M.2
  • 14
    • 0036973442 scopus 로고    scopus 로고
    • Identification of a gene linked to drug resistance in field isolates of Leishmania donovani
    • Singh,N., Singh,R.T. and Sundar,S. (2002) Identification of a gene linked to drug resistance in field isolates of Leishmania donovani. Ann. Trop. Med. Parasitol., 96, 839-841.
    • (2002) Ann. Trop. Med. Parasitol. , vol.96 , pp. 839-841
    • Singh, N.1    Singh, R.T.2    Sundar, S.3
  • 15
    • 0037119436 scopus 로고    scopus 로고
    • A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells
    • Richard,D., Kundig,C. and Ouellette,M. (2002) A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells. J. Biol. Chem., 277, 29460-29467.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29460-29467
    • Richard, D.1    Kundig, C.2    Ouellette, M.3
  • 16
    • 0035815312 scopus 로고    scopus 로고
    • Pteridine salvage throughout the Leishmania infectious cycle: Implications for antifolate chemotherapy
    • Cunningham,M.L. and Beverley,S.M. (2001) Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy. Mol. Biochem. Parasitol., 113, 199-213.
    • (2001) Mol. Biochem. Parasitol. , vol.113 , pp. 199-213
    • Cunningham, M.L.1    Beverley, S.M.2
  • 17
    • 0242698082 scopus 로고    scopus 로고
    • Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae
    • Kündig,C., Haimeur,A., Légaré,D., Papadopoulou,B. and Ouellette,M. (1999) Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae. EMBO J., 18, 2342-2351.
    • (1999) EMBO J. , vol.18 , pp. 2342-2351
    • Kündig, C.1    Haimeur, A.2    Légaré, D.3    Papadopoulou, B.4    Ouellette, M.5
  • 19
    • 0008614282 scopus 로고
    • Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica
    • Coderre,I.A., Beverley,S.M., Schimke,R.T. and Santi,D.V. (1983) Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc. Natl Acad. Sci. USA, 80, 2132-2136.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 2132-2136
    • Coderre, I.A.1    Beverley, S.M.2    Schimke, R.T.3    Santi, D.V.4
  • 20
    • 0030946111 scopus 로고    scopus 로고
    • The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
    • Nare,B., Hardy,L.W. and Beverley,S.M. (1997) The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. J. Biol. Chem., 272, 13883-13891.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13883-13891
    • Nare, B.1    Hardy, L.W.2    Beverley, S.M.3
  • 22
    • 0043264010 scopus 로고    scopus 로고
    • Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania
    • ElFadili,A., Richard,D., Kundig,C. and Ouellette,M. (2003) Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania. Biochem. Pharmacol., 66, 999-1008.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 999-1008
    • ElFadili, A.1    Richard, D.2    Kundig, C.3    Ouellette, M.4
  • 25
    • 0035992124 scopus 로고    scopus 로고
    • Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays
    • Zhang,L., Zhang,Y., Zhou,Y., An,S. and Cheng,J. (2002) Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays. J. Antimicrob. Chemother., 49, 905-915.
    • (2002) J. Antimicrob. Chemother. , vol.49 , pp. 905-915
    • Zhang, L.1    Zhang, Y.2    Zhou, Y.3    An, S.4    Cheng, J.5
  • 27
    • 0037214411 scopus 로고    scopus 로고
    • Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors
    • Ng,W.L., Kazmierczak,K.M., Robertson,G.T., Gilmour,R. and Winkler,M.E. (2003) Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors. J. Bacteriol., 185, 359-370.
    • (2003) J. Bacteriol. , vol.185 , pp. 359-370
    • Ng, W.L.1    Kazmierczak, K.M.2    Robertson, G.T.3    Gilmour, R.4    Winkler, M.E.5
  • 28
    • 0035154372 scopus 로고    scopus 로고
    • Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: Combined transcription and translation analysis
    • Gmuender,H., Kuratli,K., Di Padova,K., Gray,C.P., Keck,W. and Evers,S. (2001) Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis. Genome Res., 11, 28-42.
    • (2001) Genome Res. , vol.11 , pp. 28-42
    • Gmuender, H.1    Kuratli, K.2    Di Padova, K.3    Gray, C.P.4    Keck, W.5    Evers, S.6
  • 32
    • 0037836064 scopus 로고    scopus 로고
    • Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis
    • Saxena,A., Worthey,E.A., Yan,S., Leland,A., Stuart,K.D. and Myler,P.J. (2003) Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis. Mol. Biochem. Parasitol., 129, 103-114.
    • (2003) Mol. Biochem. Parasitol. , vol.129 , pp. 103-114
    • Saxena, A.1    Worthey, E.A.2    Yan, S.3    Leland, A.4    Stuart, K.D.5    Myler, P.J.6
  • 33
    • 0026072572 scopus 로고
    • Gene amplification in Leishmania
    • Beverley,S.M. (1991) Gene amplification in Leishmania. Annu. Rev. Microbiol., 45, 417-444.
    • (1991) Annu. Rev. Microbiol. , vol.45 , pp. 417-444
    • Beverley, S.M.1
  • 34
    • 0028822932 scopus 로고
    • New mechanisms of drug resistance in parasitic protozoa
    • Borst,P. and Ouellette,M. (1995) New mechanisms of drug resistance in parasitic protozoa. Annu. Rev. Microbiol., 49, 427-460.
    • (1995) Annu. Rev. Microbiol. , vol.49 , pp. 427-460
    • Borst, P.1    Ouellette, M.2
  • 35
    • 0026022969 scopus 로고
    • Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania
    • Ouellette,M., Hettema,E., Wust,D., Fase-Fowler,F. and Borst,P. (1991) Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. EMBO J., 10, 1009-1016.
    • (1991) EMBO J. , vol.10 , pp. 1009-1016
    • Ouellette, M.1    Hettema, E.2    Wust, D.3    Fase-Fowler, F.4    Borst, P.5
  • 36
    • 0141909066 scopus 로고    scopus 로고
    • Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms
    • Drummelsmith,J., Brochu,V., Girard,I., Messier,N. and Ouellette,M. (2003) Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms. Mol. Cell. Proteomics, 2, 146-155.
    • (2003) Mol. Cell. Proteomics , vol.2 , pp. 146-155
    • Drummelsmith, J.1    Brochu, V.2    Girard, I.3    Messier, N.4    Ouellette, M.5
  • 39
    • 0026779424 scopus 로고
    • A novel antifolate resistance gene on the amplified H circle of Leishmania
    • Papadopoulou,B., Roy,G. and Ouellette,M. (1992) A novel antifolate resistance gene on the amplified H circle of Leishmania. EMBO J., 11, 3601-3608.
    • (1992) EMBO J. , vol.11 , pp. 3601-3608
    • Papadopoulou, B.1    Roy, G.2    Ouellette, M.3
  • 40
    • 0026459643 scopus 로고
    • A member of the aldoketo reductase family confers methotrexate resistance in Leishmania
    • Callahan,H.L. and Beverley,S.M. (1992) A member of the aldoketo reductase family confers methotrexate resistance in Leishmania. J. Biol. Chem., 267, 24165-24168.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24165-24168
    • Callahan, H.L.1    Beverley, S.M.2
  • 42
    • 0027255738 scopus 로고
    • Mechanisms of drug resistance in Leishmania
    • Ouellette,M. and Papadopoulou,B. (1993) Mechanisms of drug resistance in Leishmania. Parasitol. Today, 9, 150-153.
    • (1993) Parasitol. Today , vol.9 , pp. 150-153
    • Ouellette, M.1    Papadopoulou, B.2
  • 43
    • 0030921824 scopus 로고    scopus 로고
    • New approaches to Leishmania chemotherapy: Pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
    • Nare,B., Luba,J., Hardy,L.W. and Beverley,S. (1997) New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity. Parasitology, 114 (Suppl), S101-110.
    • (1997) Parasitology , vol.114 , Issue.SUPPL.
    • Nare, B.1    Luba, J.2    Hardy, L.W.3    Beverley, S.4
  • 46
  • 48
    • 1342303735 scopus 로고    scopus 로고
    • Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray
    • Bozdech,Z., Zhu,J., Joachimiak,M.P., Cohen,F.E., Pulliam,B. and DeRisi,J.L. (2003) Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol., 4, R9.
    • (2003) Genome Biol. , vol.4
    • Bozdech, Z.1    Zhu, J.2    Joachimiak, M.P.3    Cohen, F.E.4    Pulliam, B.5    De Risi, J.L.6
  • 49
    • 0037189915 scopus 로고    scopus 로고
    • Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray
    • Diehl,S., Diehl,F., El-Sayed,N., Clayton,C. and Hoheisel,J. (2002) Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Mol. Biochem. Parasitol., 123, 115.
    • (2002) Mol. Biochem. Parasitol. , vol.123 , pp. 115
    • Diehl, S.1    Diehl, F.2    El-Sayed, N.3    Clayton, C.4    Hoheisel, J.5
  • 50
    • 0034618471 scopus 로고    scopus 로고
    • Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression
    • 1493
    • Huang,Z.A., Yang,H., Chen,C., Zeng,Z. and Lu,S.C. (2000) Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression. Biochim. Biophys. Acta, 1493, 48-55.
    • (2000) Biochim. Biophys. Acta , pp. 48-55
    • Huang, Z.A.1    Yang, H.2    Chen, C.3    Zeng, Z.4    Lu, S.C.5
  • 51
    • 0032506937 scopus 로고    scopus 로고
    • Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae
    • 1395
    • Inoue,Y., Sugiyama,K., Izawa,S. and Kimura,A. (1998) Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae. Biochim. Biophys. Acta, 1395, 315-320.
    • (1998) Biochim. Biophys. Acta , pp. 315-320
    • Inoue, Y.1    Sugiyama, K.2    Izawa, S.3    Kimura, A.4
  • 52
    • 0038730932 scopus 로고    scopus 로고
    • Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region
    • Martinez-Calvillo,S., Yan,S., Nguyen,D., Fox,M., Stuart,K. and Myler,P.J. (2003) Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol. Cell, 11, 1291-1299.
    • (2003) Mol. Cell , vol.11 , pp. 1291-1299
    • Martinez-Calvillo, S.1    Yan, S.2    Nguyen, D.3    Fox, M.4    Stuart, K.5    Myler, P.J.6
  • 53
    • 0036136732 scopus 로고    scopus 로고
    • S-Adenosylmethionine: A control switch that regulates liver function
    • Mato,J.M., Corrales,F.J., Lu,S.C. and Avila,M.A. (2002) S-Adenosylmethionine: a control switch that regulates liver function. FASEB J., 16, 15-26.
    • (2002) FASEB J. , vol.16 , pp. 15-26
    • Mato, J.M.1    Corrales, F.J.2    Lu, S.C.3    Avila, M.A.4
  • 55
    • 0032323671 scopus 로고    scopus 로고
    • Amplification of ABC transporter gene PGPA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption
    • Ouellette,M., Haimeur,A., Grondin,K., Legare,D. and Papadopoulou,B. (1998) Amplification of ABC transporter gene PGPA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption. Methods Enzymol., 292, 182-193.
    • (1998) Methods Enzymol. , vol.292 , pp. 182-193
    • Ouellette, M.1    Haimeur, A.2    Grondin, K.3    Legare, D.4    Papadopoulou, B.5
  • 56
    • 0034781171 scopus 로고    scopus 로고
    • Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin
    • Roy,G., Kundig,C., Olivier,M., Papadopoulou,B. and Ouellette,M. (2001) Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin. Exp. Parasitol., 97, 161-168.
    • (2001) Exp. Parasitol. , vol.97 , pp. 161-168
    • Roy, G.1    Kundig, C.2    Olivier, M.3    Papadopoulou, B.4    Ouellette, M.5


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