Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase

European Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2010, Pages 4490-4498

  MacCioni, E ^a   Alcaro, S ^b   Orallo, F ^c   Cardia, M C ^a   Distinto, S ^b   Costa, G ^b   Yanez, M ^c   Sanna, M L ^a   Vigo, S ^a   Meleddu, R ^a   Secci, D ^d  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b University of Catanzaro Magna Graecia   (Italy)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Dihydropyrazole synthesis and characterization; Docking; Monoamine oxidase selective inhibition; Parkinson disease

Indexed keywords

1 (N METHYLTHIOCARBAMOYL) 3 (2 FLUOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (3 FLUOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (3 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 CHLOROPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 FLUOROPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 FLUOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 METHOXYPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 METHYLPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (4 METHYLPHENYL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 (THIOPHEN 2 YL) 4,5 DIHYDROPYRAZOLE; 1 (N METHYLTHIOCARBAMOYL) 3 PHENYL 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 (N THIOCARBAMOYL) 3 (4 FLUOROPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 (N THIOCARBAMOYL) 3 PHENYL 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (2 FLUOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (2,4 DICHLOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (3 FLUOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (3 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (4 CHLOROPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (4 FLUOROPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (4 METHOXYPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (4 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (4 METHYLPHENYL) 4 METHYL 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (4 METHYLPHENYL) 4,5 DIHYDROPYRAZOLE; 1 THIOCARBAMOYL 3 (THIOPHEN 2 YL) 4,5 DIHYDROPYRAZOLE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MONOAMINE OXIDASE B INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BACULOVIRUS; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; ENZYME INHIBITION; INFRARED SPECTROSCOPY; INSECT CELL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; HUMANS; INSECTS; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN BINDING; PYRAZOLES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOAMIDES;

EID: 77956184314     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.009     Document Type: Article

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