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Volumn 94, Issue 2, 2012, Pages 197-205

Autophagy as a therapeutic target for ischaemia/reperfusion injury? Concepts, controversies, and challenges

Author keywords

Autophagy; Myocardial ischaemia; Myocardial reperfusion; Reperfusion injury

Indexed keywords

2 CHLOROCYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; AUTOPHAGY PROTEIN 5; BECLIN 1; CHLORAMPHENICOL HEMISUCCINATE; COLLAGEN; DIAZOXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; RANOLAZINE; SULFAPHENAZOLE; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG;

EID: 84860210734     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr358     Document Type: Review
Times cited : (126)

References (80)
  • 1
    • 80052554958 scopus 로고    scopus 로고
    • New horizons in cardioprotection: Recommendations from the 2010 national heart, lung, and blood institute workshop
    • Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E et al. New horizons in cardioprotection: recommendations from the 2010 national heart, lung, and blood institute workshop. Circulation 2011;124:1172-1179.
    • (2011) Circulation , vol.124 , pp. 1172-1179
    • Schwartz Longacre, L.1    Kloner, R.A.2    Arai, A.E.3    Baines, C.P.4    Bolli, R.5    Braunwald, E.6
  • 3
    • 80051514092 scopus 로고    scopus 로고
    • Clinical efforts to reduce myocardial infarct size: The next step
    • Braunwald E. Clinical efforts to reduce myocardial infarct size: the next step. J Cardiovasc Pharmacol Ther 2011;16:349-353.
    • (2011) J Cardiovasc Pharmacol Ther , vol.16 , pp. 349-353
    • Braunwald, E.1
  • 4
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • DOI 10.1126/science.290.5497.1717
    • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717-1721. (Pubitemid 32004796)
    • (2000) Science , vol.290 , Issue.5497 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 5
    • 0347626252 scopus 로고    scopus 로고
    • Autophagy: A regulated bulk degradation process inside cells
    • DOI 10.1016/j.bbrc.2003.07.023
    • Yoshimori T. Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Commun 2004;313:453-458. (Pubitemid 37543608)
    • (2004) Biochemical and Biophysical Research Communications , vol.313 , Issue.2 , pp. 453-458
    • Yoshimori, T.1
  • 6
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • DOI 10.1126/science.1099993
    • Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004;306:990-995. (Pubitemid 39482894)
    • (2004) Science , vol.306 , Issue.5698 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 7
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • DOI 10.1038/sj.cdd.4401751, PII 4401751
    • Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005;12(Suppl. 2):1509-1518. (Pubitemid 41553987)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 8
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007;9:1102-1109. (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 9
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • DOI 10.1101/gad.1599207
    • Mizushima N. Autophagy: process and function. Genes Dev 2007;21:2861-2873. (Pubitemid 350133435)
    • (2007) Genes and Development , vol.21 , Issue.22 , pp. 2861-2873
    • Mizushima, N.1
  • 10
    • 59849110194 scopus 로고    scopus 로고
    • Autophagy in ischemic heart disease
    • Gustafsson AB, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res 2009;104: 150-158.
    • (2009) Circ Res , vol.104 , pp. 150-158
    • Gustafsson, A.B.1    Gottlieb, R.A.2
  • 13
    • 79953736356 scopus 로고    scopus 로고
    • Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart?
    • Sciarretta S, Hariharan N, Monden Y, Zablocki D, Sadoshima J. Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol 2011;32:275-281.
    • (2011) Pediatr Cardiol , vol.32 , pp. 275-281
    • Sciarretta, S.1    Hariharan, N.2    Monden, Y.3    Zablocki, D.4    Sadoshima, J.5
  • 15
    • 77951915586 scopus 로고    scopus 로고
    • Autophagy during cardiac stress: Joys and frustrations of autophagy
    • Gottlieb RA, Mentzer RM. Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 2010;72:45-59.
    • (2010) Annu Rev Physiol , vol.72 , pp. 45-59
    • Gottlieb, R.A.1    Mentzer, R.M.2
  • 16
    • 33749570745 scopus 로고    scopus 로고
    • Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    • DOI 10.1074/jbc.M603783200
    • Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 2006;281: 29 776-29 787. (Pubitemid 44536987)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.40 , pp. 29776-29787
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 17
    • 79956126271 scopus 로고    scopus 로고
    • Oxidative stress stimulates autophagic flux during ischemia/reperfusion
    • Hariharan N, Zhai P, Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal 2011;14:2179-2190.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2179-2190
    • Hariharan, N.1    Zhai, P.2    Sadoshima, J.3
  • 18
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007;3:452-460. (Pubitemid 47293726)
    • (2007) Autophagy , vol.3 , Issue.5 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 22
    • 67650261911 scopus 로고    scopus 로고
    • Cell death: A dynamic response concept
    • Loos B, Engelbrecht AM. Cell death: a dynamic response concept. Autophagy 2009;5: 590-603.
    • (2009) Autophagy , vol.5 , pp. 590-603
    • Loos, B.1    Engelbrecht, A.M.2
  • 23
    • 79955963895 scopus 로고    scopus 로고
    • At the core of survival: Autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury
    • Loos B, Genade S, Ellis B, Lochner A, Engelbrecht AM. At the core of survival: autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Exp Cell Res 2011;317:1437-1453.
    • (2011) Exp Cell Res , vol.317 , pp. 1437-1453
    • Loos, B.1    Genade, S.2    Ellis, B.3    Lochner, A.4    Engelbrecht, A.M.5
  • 24
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • DOI 10.1038/nrm2239, PII NRM2239
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007;8:741-752. (Pubitemid 47312826)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 25
    • 80051535614 scopus 로고    scopus 로고
    • How and when do myocytes die during ischemia and reperfusion: The late phase
    • Baines CP. How and when do myocytes die during ischemia and reperfusion: the late phase. J Cardiovasc Pharmacol Ther 2011;16:239-243.
    • (2011) J Cardiovasc Pharmacol Ther , vol.16 , pp. 239-243
    • Baines, C.P.1
  • 26
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and beclin 1 in mediating autophagy
    • DOI 10.1161/01.RES.0000261924.76669.36
    • Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 2007;100:914-922. (Pubitemid 46555697)
    • (2007) Circulation Research , vol.100 , Issue.6 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3    Abdellatif, M.4    Sakoda, H.5    Asano, T.6    Levine, B.7    Sadoshima, J.8
  • 28
    • 77949357437 scopus 로고    scopus 로고
    • Cardioprotection by resveratrol: A novel mechanism via autophagy involving the mTORC2 pathway
    • Gurusamy N, Lekli I, Mukherjee S, Ray D, Ahsan MK, Gherghiceanu M et al. Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res 2010;86:103-112.
    • (2010) Cardiovasc Res , vol.86 , pp. 103-112
    • Gurusamy, N.1    Lekli, I.2    Mukherjee, S.3    Ray, D.4    Ahsan, M.K.5    Gherghiceanu, M.6
  • 30
    • 78149469146 scopus 로고    scopus 로고
    • Autophagy in myocardium of murine hearts subjected to ischemia followed by reperfusion
    • French CJ, Taatjes DJ, Sobel BE. Autophagy in myocardium of murine hearts subjected to ischemia followed by reperfusion. Histochem Cell Biol 2010;134:519-526.
    • (2010) Histochem Cell Biol , vol.134 , pp. 519-526
    • French, C.J.1    Taatjes, D.J.2    Sobel, B.E.3
  • 31
    • 38349138807 scopus 로고    scopus 로고
    • Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
    • May D, Gilon D, Djonov V, Itin A, Lazarus A, Gordon O et al. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci USA 2008;105:282-287.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 282-287
    • May, D.1    Gilon, D.2    Djonov, V.3    Itin, A.4    Lazarus, A.5    Gordon, O.6
  • 32
    • 43949114864 scopus 로고    scopus 로고
    • Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion
    • Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T et al. Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy 2008;4:409-415. (Pubitemid 351705136)
    • (2008) Autophagy , vol.4 , Issue.4 , pp. 409-415
    • Matsui, Y.1    Kyoi, S.2    Takagi, H.3    Hsu, C.-P.4    Hariharan, N.5    Ago, T.6    Vatner, S.F.7    Sadoshima, J.8
  • 34
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005;8: 3-5.
    • (2005) Rejuvenation Res , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 36
    • 33748424981 scopus 로고    scopus 로고
    • Protective effect of autophagy in anoxia-reoxygenation of isolated cardiomyocyte?
    • Dosenko VE, Nagibin VS, Tumanovska LV, Moibenko AA. Protective effect of autophagy in anoxia-reoxygenation of isolated cardiomyocyte? Autophagy 2006;2:305-306. (Pubitemid 44342376)
    • (2006) Autophagy , vol.2 , Issue.4 , pp. 305-306
    • Dosenko, V.E.1    Nagibin, V.S.2    Tumanovska, L.V.3    Moibenko, A.A.4
  • 37
    • 70350500068 scopus 로고    scopus 로고
    • FoxO transcription factors promote autophagy in cardiomyocytes
    • Sengupta A, Molkentin JD, Yutzey KE. FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem 2009;284:28 319-28 331.
    • (2009) J Biol Chem , vol.284 , pp. 28319-28331
    • Sengupta, A.1    Molkentin, J.D.2    Yutzey, K.E.3
  • 38
    • 79953186624 scopus 로고    scopus 로고
    • FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    • Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem 2011;286:7468-7478.
    • (2011) J Biol Chem , vol.286 , pp. 7468-7478
    • Sengupta, A.1    Molkentin, J.D.2    Paik, J.H.3    Depinho, R.A.4    Yutzey, K.E.5
  • 39
    • 84856347915 scopus 로고    scopus 로고
    • STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy
    • doi: 10.1111/j.1582-4934.2011.01323.x. Published online ahead of print March 29, 2011
    • McCormick J, Suleman N, Scarabelli TM, Knight RA, Latchman DS, Stephanou A. STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy. J Cell Mol Med 2011; doi: 10.1111/j.1582-4934.2011.01323.x. Published online ahead of print March 29, 2011.
    • (2011) J Cell Mol Med
    • McCormick, J.1    Suleman, N.2    Scarabelli, T.M.3    Knight, R.A.4    Latchman, D.S.5    Stephanou, A.6
  • 43
    • 77952289056 scopus 로고    scopus 로고
    • Ischemic postconditioning reduces infarct size of the in vivo rat heart: Role of PI3-K, mTOR, GSK-3beta, and apoptosis
    • Wagner C, Tillack D, Simonis G, Strasser RH, Weinbrenner C. Ischemic postconditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3beta, and apoptosis. Mol Cell Biochem 2010;339:135-147.
    • (2010) Mol Cell Biochem , vol.339 , pp. 135-147
    • Wagner, C.1    Tillack, D.2    Simonis, G.3    Strasser, R.H.4    Weinbrenner, C.5
  • 44
    • 67650228581 scopus 로고    scopus 로고
    • Autophagy in ischemic preconditioning and hibernating myocardium
    • Yan L, Sadoshima J, Vatner DE, Vatner SF. Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy 2009;5:709-712.
    • (2009) Autophagy , vol.5 , pp. 709-712
    • Yan, L.1    Sadoshima, J.2    Vatner, D.E.3    Vatner, S.F.4
  • 45
    • 24044437475 scopus 로고    scopus 로고
    • Postconditioning prevents apoptotic necrotic and autophagic cardiomyocyte cell death in culture
    • Dosenko VE, Nagibin VS, Tumanovskaya LV, Moibenko AA, Vaage J. Postconditioning prevents apoptotic necrotic and autophagic cardiomyocyte cell death in culture. Fiziol Zh 2005;51:12-17.
    • (2005) Fiziol Zh , vol.51 , pp. 12-17
    • Dosenko, V.E.1    Nagibin, V.S.2    Tumanovskaya, L.V.3    Moibenko, A.A.4    Vaage, J.5
  • 46
    • 80052147341 scopus 로고    scopus 로고
    • Differential roles of GSK-3{beta} during myocardial ischemia and ischemia/reperfusion
    • Zhai P, Sciarretta S, Galeotti J, Volpe M, Sadoshima J. Differential roles of GSK-3{beta} during myocardial ischemia and ischemia/reperfusion. Circ Res 2011;109:502-511.
    • (2011) Circ Res , vol.109 , pp. 502-511
    • Zhai, P.1    Sciarretta, S.2    Galeotti, J.3    Volpe, M.4    Sadoshima, J.5
  • 49
    • 77950576949 scopus 로고    scopus 로고
    • Autophagy in hypertensive heart disease
    • Wang ZV, Rothermel BA, Hill JA. Autophagy in hypertensive heart disease. J Biol Chem 2010;285:8509-8514.
    • (2010) J Biol Chem , vol.285 , pp. 8509-8514
    • Wang, Z.V.1    Rothermel, B.A.2    Hill, J.A.3
  • 50
    • 71649084135 scopus 로고    scopus 로고
    • Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction
    • Buss SJ, Muenz S, Riffel JH, Malekar P, Hagenmueller M, Weiss CS et al. Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J Am Coll Cardiol 2009;54:2435-2446.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2435-2446
    • Buss, S.J.1    Muenz, S.2    Riffel, J.H.3    Malekar, P.4    Hagenmueller, M.5    Weiss, C.S.6
  • 53
    • 80755153564 scopus 로고    scopus 로고
    • Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: Role of fibroblast autophagy
    • Marchesi C, Essalmani R, Lemarie CA, Leibovitz E, Ebrahimian T, Paradis P et al. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. J Mol Med 2011;89:1103-1111.
    • (2011) J Mol Med , vol.89 , pp. 1103-1111
    • Marchesi, C.1    Essalmani, R.2    Lemarie, C.A.3    Leibovitz, E.4    Ebrahimian, T.5    Paradis, P.6
  • 55
    • 0036136667 scopus 로고    scopus 로고
    • The inflammatory response in myocardial infarction
    • DOI 10.1016/S0008-6363(01)00434-5, PII S0008636301004345
    • Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 2002;53:31-47. (Pubitemid 34020764)
    • (2002) Cardiovascular Research , vol.53 , Issue.1 , pp. 31-47
    • Frangogiannis, N.G.1    Smith, C.W.2    Entman, M.L.3
  • 56
    • 0024212281 scopus 로고
    • Acute reoxygenation injury in the isolated rat heart: Role of resident cardiac mast cells
    • Keller AM, Clancy RM, Barr ML, Marboe CC, Cannon PJ. Acute reoxygenation injury in the isolated rat heart: role of resident cardiac mast cells. Circ Res 1988;63: 1044-1052. (Pubitemid 19004259)
    • (1988) Circulation Research , vol.63 , Issue.6 , pp. 1044-1052
    • Keller, A.M.1    Clancy, R.M.2    Barr, M.L.3    Marboe, C.C.4    Cannon, P.J.5
  • 57
    • 50849088969 scopus 로고    scopus 로고
    • Extracellular matrix regulation of autophagy
    • Lock R, Debnath J. Extracellular matrix regulation of autophagy. Curr Opin Cell Biol 2008;20:583-588.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 583-588
    • Lock, R.1    Debnath, J.2
  • 58
    • 78650850705 scopus 로고    scopus 로고
    • Regulation of autophagy by extracellular matrix glycoproteins in HeLa cells
    • Tuloup-Minguez V, Greffard A, Codogno P, Botti J. Regulation of autophagy by extracellular matrix glycoproteins in HeLa cells. Autophagy 2011;7:27-39.
    • (2011) Autophagy , vol.7 , pp. 27-39
    • Tuloup-Minguez, V.1    Greffard, A.2    Codogno, P.3    Botti, J.4
  • 60
    • 62249157748 scopus 로고    scopus 로고
    • Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA
    • Yitzhaki S, Huang C, Liu W, Lee Y, Gustafsson AB, Mentzer RM Jr et al. Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol 2009;104:157-167.
    • (2009) Basic Res Cardiol , vol.104 , pp. 157-167
    • Yitzhaki, S.1    Huang, C.2    Liu, W.3    Lee, Y.4    Gustafsson, A.B.5    Mentzer Jr., R.M.6
  • 61
    • 33746090919 scopus 로고    scopus 로고
    • Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes
    • DOI 10.1016/j.yjmcc.2006.04.014, PII S0022282806005268
    • Khan S, Salloum F, Das A, Xi L, Vetrovec GW, Kukreja RC. Rapamycin confers preconditioning-like protection against ischemia/reperfusion injury in isolated mouse heart and cardiomyocytes. J Mol Cell Cardiol 2006;41:256-264. (Pubitemid 44080210)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , Issue.2 , pp. 256-264
    • A. Khan, S.1    Salloum, F.2    Das, A.3    Xi, L.4    W. Vetrovec, G.5    C. Kukreja, R.6
  • 62
    • 78549272759 scopus 로고    scopus 로고
    • Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action
    • Mukherjee S, Ray D, Lekli I, Bak I, Tosaki A, Das DK. Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action. Can J Physiol Pharmacol 2010;88:1017-1025.
    • (2010) Can J Physiol Pharmacol , vol.88 , pp. 1017-1025
    • Mukherjee, S.1    Ray, D.2    Lekli, I.3    Bak, I.4    Tosaki, A.5    Das, D.K.6
  • 64
    • 77957221783 scopus 로고    scopus 로고
    • Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia/reperfusion injury
    • Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM Jr et al. Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia/reperfusion injury. Circulation 2010;122(Suppl. 11):S179-S184.
    • (2010) Circulation , vol.122 , Issue.SUPPL. 11
    • Sala-Mercado, J.A.1    Wider, J.2    Undyala, V.V.3    Jahania, S.4    Yoo, W.5    Mentzer Jr., R.M.6
  • 66
    • 69449092724 scopus 로고    scopus 로고
    • Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
    • Wu YT, Tan HL, Huang Q, Ong CN, Shen HM. Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy 2009;5:824-834.
    • (2009) Autophagy , vol.5 , pp. 824-834
    • Wu, Y.T.1    Tan, H.L.2    Huang, Q.3    Ong, C.N.4    Shen, H.M.5
  • 67
    • 33646047765 scopus 로고    scopus 로고
    • Survival kinases in ischemic preconditioning and postconditioning
    • Hausenloy DJ, Yellon DM. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res 2006;70:240-253.
    • (2006) Cardiovasc Res , vol.70 , pp. 240-253
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 68
    • 34548044947 scopus 로고    scopus 로고
    • Preconditioning and postconditioning: United at reperfusion
    • DOI 10.1016/j.pharmthera.2007.06.005, PII S0163725807001258
    • Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 2007;116:173-191. (Pubitemid 47451505)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.2 , pp. 173-191
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 69
    • 78349242462 scopus 로고    scopus 로고
    • Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria K(ATP) channel
    • Yang SS, Liu YB, Yu JB, Fan Y, Tang SY, Duan WT et al. Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria K(ATP) channel. Pharmazie 2010;65:760-765.
    • (2010) Pharmazie , vol.65 , pp. 760-765
    • Yang, S.S.1    Liu, Y.B.2    Yu, J.B.3    Fan, Y.4    Tang, S.Y.5    Duan, W.T.6
  • 70
    • 23944457139 scopus 로고    scopus 로고
    • Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: Role of inositol trisphosphate receptors and gap junctions in triggering protection
    • DOI 10.1124/jpet.105.087742
    • Przyklenk K, Maynard M, Darling CE, Whittaker P. Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: role of inositol trisphosphate receptors and gap junctions in triggering protection. J Pharmacol Exp Ther 2005; 314:1386-1392. (Pubitemid 41206006)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.314 , Issue.3 , pp. 1386-1392
    • Przyklenk, K.1    Maynard, M.2    Darling, C.E.3    Whittaker, P.4
  • 71
    • 33644862832 scopus 로고    scopus 로고
    • Reduction of infarct size with D-myo-inositol trisphosphate: Role of PI3-kinase and mitochondrial K(ATP) channels
    • Przyklenk K, Maynard M, Whittaker P. Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels. Am J Physiol Heart Circ Physiol 2006;290:H830-H836.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Przyklenk, K.1    Maynard, M.2    Whittaker, P.3
  • 72
    • 74949085029 scopus 로고    scopus 로고
    • Effect of hydrogen sulfide in a porcine model of myocardial ischemia/reperfusion: Comparison of different administration regimens and characterization of the cellular mechanisms of protection
    • Osipov RM, Robich MP, Feng J, Liu Y, Clements RT, Glazer HP et al. Effect of hydrogen sulfide in a porcine model of myocardial ischemia/reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection. J Cardiovasc Pharmacol 2009;54:287-297.
    • (2009) J Cardiovasc Pharmacol , vol.54 , pp. 287-297
    • Osipov, R.M.1    Robich, M.P.2    Feng, J.3    Liu, Y.4    Clements, R.T.5    Glazer, H.P.6
  • 73
    • 77950666590 scopus 로고    scopus 로고
    • Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass
    • Osipov RM, Robich M, Feng J, Chan V, Clements RT, Deyo RJ et al. Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass. Interact Cardiovasc Thorac Surg 2010;10:506-512.
    • (2010) Interact Cardiovasc Thorac Surg , vol.10 , pp. 506-512
    • Osipov, R.M.1    Robich, M.2    Feng, J.3    Chan, V.4    Clements, R.T.5    Deyo, R.J.6
  • 74
    • 37549038706 scopus 로고    scopus 로고
    • Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    • Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 2007;59:418-458.
    • (2007) Pharmacol Rev , vol.59 , pp. 418-458
    • Ferdinandy, P.1    Schulz, R.2    Baxter, G.F.3
  • 75
    • 41149127345 scopus 로고    scopus 로고
    • Aging mouse hearts are refractory to infarct size reduction with post-conditioning
    • DOI 10.1016/j.jacc.2007.11.070, PII S0735109708003306
    • Przyklenk K, Maynard M, Darling CE, Whittaker P. Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol 2008;51:1393-1398. (Pubitemid 351443077)
    • (2008) Journal of the American College of Cardiology , vol.51 , Issue.14 , pp. 1393-1398
    • Przyklenk, K.1    Maynard, M.2    Darling, C.E.3    Whittaker, P.4
  • 76
    • 79551672046 scopus 로고    scopus 로고
    • Cardioprotection with postconditioning: Loss of efficacy in murine models of type-2 and type-1 diabetes
    • Przyklenk K, Maynard M, Greiner DL, Whittaker P. Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes. Antioxid Redox Signal 2011;14:781-790.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 781-790
    • Przyklenk, K.1    Maynard, M.2    Greiner, D.L.3    Whittaker, P.4
  • 77
    • 79955678054 scopus 로고    scopus 로고
    • Efficacy of cardioprotective 'conditioning' strategies in aging and diabetic cohorts: The co-morbidity conundrum
    • Przyklenk K. Efficacy of cardioprotective 'conditioning' strategies in aging and diabetic cohorts: the co-morbidity conundrum. Drugs Aging 2011;28:331-343.
    • (2011) Drugs Aging , vol.28 , pp. 331-343
    • Przyklenk, K.1
  • 78
    • 80051502724 scopus 로고    scopus 로고
    • The role of comorbidities in cardioprotection
    • Sack MN, Murphy E. The role of comorbidities in cardioprotection. J Cardiovasc Pharmacol Ther 2011;16:267-272.
    • (2011) J Cardiovasc Pharmacol Ther , vol.16 , pp. 267-272
    • Sack, M.N.1    Murphy, E.2
  • 79
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    • DOI 10.1046/j.1432-1033.2002.02869.x
    • Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002;269:1996-2002. (Pubitemid 34437840)
    • (2002) European Journal of Biochemistry , vol.269 , Issue.8 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2


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