The role of comorbidities in cardioprotection

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 16, Issue 3-4, 2011, Pages 267-272

  Sack, Michael N ^a   Murphy, Elizabeth ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

heart disease; ischemia reperfusion injury; metabolic syndrome

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; RESVERATROL; TETRAHYDROBIOPTERIN;

AGING; CALORIC RESTRICTION; COMORBIDITY; CONFERENCE PAPER; ENZYME ACTIVATION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; MENOPAUSE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REPERFUSION INJURY; RISK FACTOR; SEX DIFFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOTONIC AGENTS; CLINICAL TRIALS AS TOPIC; COMORBIDITY; DEAFNESS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; HUMANS; HYPERCHOLESTEROLEMIA; HYPERTENSION; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL REPERFUSION INJURY; OBESITY; SEX FACTORS;

EID: 80051502724     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248411408313     Document Type: Conference Paper

References (54)

1. Bolli R, Becker L, Gross G, Mentzer R, Balshaw D, Lathrop DA. Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res. 2004 ; 95 (2). 125-134 (Pubitemid 38988678)
2. Murphy E, Allen DG. Why did the NHE inhibitor clinical trials fail?. J Mol Cell Cardiol. 2009 ; 46 (2). 137-141
3. Boyce SW, Bartels C, Bolli R, et al. Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study. J Thorac Cardiovasc Surg. 2003 ; 126 (2). 420-427 (Pubitemid 37048507)
4. Ovize M, Baxter GF, Di Lisa F, et al. Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res. 2010 ; 87 (3). 406-423
5. Balakumar P, Singh H, Singh M, Anand-Srivastava MB. The impairment of preconditioning-mediated cardioprotection in pathological conditions. Pharmacol Res. 2009 ; 60 (1). 18-23
6. Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev. 2007 ; 59 (4). 418-458
7. Lagranha CJ, Deschamps A, Aponte A, Steenbergen C, Murphy E. Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females. Circ Res. 2010 ; 106 (11). 1681-1691
8. Bae S, Zhang L. Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling. J Pharmacol Exp Ther. 2005 ; 315 (3). 1125-1135 (Pubitemid 41635399)
9. Sun J, Picht E, Ginsburg KS, Bers DM, Steenbergen C, Murphy E. Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res. 2006 ; 98 (3). 403-411
10. Hale SL, Birnbaum Y, Kloner RA. beta-Estradiol, but not alpha-estradiol, reduced myocardial necrosis in rabbits after ischemia and reperfusion. Am Heart J. 1996 ; 132 (2)(pt 1). 258-262 (Pubitemid 26292388)
11. Booth EA, Obeid NR, Lucchesi BR. Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 ; 289 (5). H2039-H2047
12. Talukder MA, Yang F, Shimokawa H, Zweier JL. eNOS is required for acute in vivo ischemic preconditioning of the heart: effects of ischemic duration and sex. Am J Physiol Heart Circ Physiol. 2010 ; 299 (2). H437-H445
13. Penna C, Tullio F, Merlino A, et al. Postconditioning cardioprotection against infarct size and post-ischemic systolic dysfunction is influenced by gender. Basic Res Cardiol. 2009 ; 104 (4). 390-402
14. Shinmura K, Nagai M, Tamaki K, Bolli R. Gender and aging do not impair opioid-induced late preconditioning in rats. Basic Res Cardiol. 2004 ; 99 (1). 46-55 (Pubitemid 38049139)
15. Jones SP, Bolli R. The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol. 2006 ; 40 (1). 16-23 (Pubitemid 43012113)
16. Shinmura K, Nagai M, Tamaki K, Bolli R. Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C epsilon phosphorylation. Cardiovasc Res. 2008 ; 79 (3). 387-394
17. Osipov RM, Bianchi C, Feng J, et al. Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion. Circulation. 2009 ; 120 (11)(suppl). S22-S30
18. Tang XL, Takano H, Xuan YT, et al. Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits. Circulation. 2005 ; 112 (14). 2149-2156 (Pubitemid 41475809)
19. Iliodromitis EK, Zoga A, Vrettou A, et al. The effectiveness of postconditioning and preconditioning on infarct size in hypercholesterolemic and normal anesthetized rabbits. Atherosclerosis. 2006 ; 188 (2). 356-362 (Pubitemid 44313925)
20. Szilvassy Z, Ferdinandy P, Szilvassy J, et al. The loss of pacing-induced preconditioning in atherosclerotic rabbits: role of hypercholesterolaemia. J Mol Cell Cardiol. 1995 ; 27 (12). 2559-2569 (Pubitemid 26003185)
21. Ungi I, Ungi T, Ruzsa Z, et al. Hypercholesterolemia attenuates the anti-ischemic effect of preconditioning during coronary angioplasty. Chest. 2005 ; 128 (3). 1623-1628 (Pubitemid 41324456)
22. Tang XL, Stein AB, Shirk G, Bolli R. Hypercholesterolemia blunts NO donor-induced late preconditioning against myocardial infarction in conscious rabbits. Basic Res Cardiol. 2004 ; 99 (6). 395-403 (Pubitemid 39462362)
23. Kupai K, Csonka C, Fekete V, et al. Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite. Am J Physiol Heart Circ Physiol. 2009 ; 297 (5). H1729-H1735
24. Ferdinandy P. Myocardial ischaemia/reperfusion injury and preconditioning: effects of hypercholesterolaemia/hyperlipidaemia. Br J Pharmacol. 2003 ; 138 (2). 283-285 (Pubitemid 36188588)
25. Donato M, D'Annunzio V, Berg G, et al. Ischemic postconditioning reduces infarct size by activation of A1 receptors and K+(ATP) channels in both normal and hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 2007 ; 49 (5). 287-292 (Pubitemid 46855122)
26. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med. 2007 ; 356 (3). 213-215 (Pubitemid 46143224)
27. Fox CS, Coady S, Sorlie PD, et al. Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study. Circulation. 2007 ; 115 (12). 1544-1550 (Pubitemid 46648639)
28. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation. 2005 ; 112 (17). 2686-2695 (Pubitemid 41532606)
29. Sack MN. Type 2 diabetes, mitochondrial biology and the heart. J Mol Cell Cardiol. 2009 ; 46 (6). 842-849
30. Murphy E, Steenbergen C. What makes the mitochondria a killer? Can we condition them to be less destructive?. Biochim Biophys Acta. 2010 ;:
31. Sack MN. Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance. Cardiovasc Res. 2006 ; 72 (2). 210-219 (Pubitemid 44515171)
32. Gottlieb RA, Gustafsson AB. Mitochondrial turnover in the heart. Biochim Biophys Acta. 2010 ;:
33. Sindler AL, Fleenor BS, Calvert JW, et al. Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging Cell. 2011 ;:
34. Sasaki N, Yamashita T, Takaya T, et al. Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus. Arterioscler Thromb Vasc Biol. 2008 ; 28 (6). 1068-1076
35. Settergren M, Bohm F, Malmstrom RE, Channon KM, Pernow J. l-Arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atherosclerosis. 2009 ; 204 (1). 73-78
36. Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH. Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation. 2007 ; 116 (8). 944-953 (Pubitemid 47300919)
37. Ishihara M, Inoue I, Kawagoe T, et al. Diabetes mellitus prevents ischemic preconditioning in patients with a first acute anterior wall myocardial infarction. J Am Coll Cardiol. 2001 ; 38 (4). 1007-1011 (Pubitemid 32912703)
38. Mathew V, Gersh BJ, Williams BA, et al. Outcomes in patients with diabetes mellitus undergoing percutaneous coronary intervention in the current era: a report from the Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. Circulation. 2004 ; 109 (4). 476-480 (Pubitemid 38168509)
39. Przyklenk K, Maynard M, Greiner DL, Whittaker P. Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes. Antioxid Redox Signal. 2011 ; 14 (5). 781-790
40. Petersen KF, Befroy D, Dufour S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science. 2003 ; 300 (5622). 1140-1142 (Pubitemid 36583097)
41. Kelly DP. Cell biology: ageing theories unified. Nature. 2011 ; 470 (7334). 342-343
42. Yang YM, Huang A, Kaley G, Sun D. eNOS uncoupling and endothelial dysfunction in aged vessels. Am J Physiol Heart Circ Physiol. 2009 ; 297 (5). H1829-H1836
43. Pierce GL, Larocca TJ. Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?. J Physiol. 2008 ; 586 (pt 11). 2673-2674 (Pubitemid 351761784)
44. Boengler K, Schulz R, Heusch G. Loss of cardioprotection with ageing. Cardiovasc Res. 2009 ; 83 (2). 247-261
45. Niemann B, Chen Y, Issa H, Silber RE, Rohrbach S. Caloric restriction delays cardiac ageing in rats: role of mitochondria. Cardiovasc Res. 2010 ; 88 (2). 267-276
46. Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL. Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev. 2010 ; 131 (11-12). 739-742
47. Morris KC, Lin HW, Thompson JW, Perez-Pinzon MA. Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab. 2011 ; 31 (4). 1003-1019
48. Landmesser U, Dikalov S, Price SR, et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest. 2003 ; 111 (8). 1201-1209 (Pubitemid 36519937)
49. Moens AL, Kass DA. Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. J Cardiovasc Pharmacol. 2007 ; 50 (3). 238-246 (Pubitemid 47428970)
50. Pannirselvam M, Verma S, Anderson TJ, Triggle CR. Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db-/-) mice: role of decreased tetrahydrobiopterin bioavailability. Br J Pharmacol. 2002 ; 136 (2). 255-263 (Pubitemid 34587672)
51. Dumitrescu C, Biondi R, Xia Y, et al. Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. Proc Natl Acad Sci USA. 2007 ; 104 (38). 15081-15086 (Pubitemid 47619596)
52. Xia Y, Tsai AL, Berka V, Zweier JL. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem. 1998 ; 273 (40). 25804-25808
53. Moens AL, Leyton-Mange JS, Niu X, et al. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol. 2009 ; 47 (5). 576-585
54. White RE, Gerrity R, Barman SA, Han G. Estrogen and oxidative stress: a novel mechanism that may increase the risk for cardiovascular disease in women. Steroids. 2010 ; 75 (11). 788-793