Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells

Biochemical Pharmacology

Volumn 72, Issue 6, 2006, Pages 681-692

  Vargo, Melissa A ^a,c   Voss, Oliver H ^a   Poustka, Frantisek ^b   Cardounel, Arturo J ^d   Grotewold, Erich ^b   Doseff, Andrea I ^a,c,d  

^a Department of Molecular Genetics ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Cellular and Development Biology Graduate Program   (United States)

^d Davis Heart and Lung Research Institute   (United States)

Author keywords

Apigenin induced apoptosis; Caspase; Leukemia; PKC

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTINEOPLASTIC AGENT; APIGENIN; CASPASE; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; FLAVONOID; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NARINGENIN; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; ROTTLERIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MITOCHONDRION; MONOCYTIC LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3T3 CELLS; ANIMALS; APIGENIN; APOPTOSIS; CASPASE 3; CASPASE 9; CASPASES; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; JURKAT CELLS; K562 CELLS; LEUKEMIA; MICE; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C-DELTA; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 33747188963     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.010     Document Type: Article

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